Estrogen Receptor alpha Antibody | Bioss bs-0725R product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Bioss

product type :

antibody

product name :

Estrogen Receptor alpha Antibody

catalog :

bs-0725R

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Wu Y, Feng D, Lin J, Qu Y, He S, Wang Y, et al. Downregulation of G‑protein‑coupled receptor 30 in the hippocampus attenuates the neuroprotection of estrogen in the critical period hypothesis. Mol Med Rep. 2018;17:5716-5725 pubmed publisher

product information

sku :

bs-0725R

name :

Estrogen Receptor alpha Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Estrogen Receptor alpha

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

570-600/600

subcellular locations :

Cytoplasm, Nucleus

source :

KLH conjugated synthetic peptide derived from rat ER-alpha

gene id link :

Entrez Gene: 24890

swiss prot :

P06211

swiss prot link :

Swiss Prot: P06211

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Mouse, Rat

size :

100 ul

background :

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

Esr; ER-alpha; RNESTROR; Estrogen receptor; ER; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1; Esr1; Estr; Nr3a1

lead time :

3 to 5 business days.