Met (c Met) Polyclonal Antibody | Bioss bs-0668R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Met (c Met) Polyclonal Antibody

catalog :

bs-0668R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

alpaca, human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse	Wang X, Tang Y, Shen R, Chen J, Chen G, Luo G, et al. Hepatocyte growth factor (HGF) optimizes oral traumatic ulcer healing of mice by reducing inflammation.. Cytokine. 2017;99:275-280 pubmed publisher
immunohistochemistry - paraffin section; alpaca; 1:50; loading ...; fig 1 western blot; alpaca; 1:2000; loading ...; fig 2a	Yu X, He X, Jiang J, He J, Fan R, Wang H, et al. Expression and tissue distribution of hepatocyte growth factor (HGF) and its receptor (c-Met) in alpacas (Vicugna pacos) skins associated with white and brown coat colors. Acta Histochem. 2015;117:624-8 pubmed publisher
immunohistochemistry - paraffin section; human	Li H, Zhang H, Zhao S, Shi Y, Yao J, Zhang Y, et al. Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer.. Oncol Lett. 2015;9:1989-1996 pubmed publisher
immunohistochemistry - paraffin section; human western blot; human	Gao W, Bing X, Li M, Yang Z, Li Y, Chen H. Study of critical role of c-Met and its inhibitor SU11274 in colorectal carcinoma. Med Oncol. 2013;30:546 pubmed publisher

product information

sku :

bs-0668R

name :

Met (c Met) Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Met (c-Met)

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

25-75/1390

subcellular locations :

Extracellular

source :

KLH conjugated synthetic peptide derived from human Met (c-Met)

gene id link :

Entrez Gene: 4233

swiss prot :

P08581

swiss prot link :

Swiss Prot: P08581

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

HGFR; AUTS9; RCCP2; c-Met; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage