Cyclin D1 Polyclonal Antibody | Bioss bs-0623R product information

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product summary

company name :

Bioss

product type :

antibody

product name :

Cyclin D1 Polyclonal Antibody

catalog :

bs-0623R

quantity :

100 ul

price :

279.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 15

Published Application/Species/Dilution	Reference
immunohistochemistry - paraffin section; cat; 1:2000; fig 5b	Poncelet L, Garigliany M, Ando K, Franssen M, Desmecht D, Brion J. Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus. Cell Cycle. 2016;15:3482-3489 pubmed publisher
immunohistochemistry - paraffin section; human; fig 3	Huang C, Liu H, Gong X, Wen B, Chen D, Liu J, et al. Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis. Mol Med Rep. 2016;14:2555-65 pubmed publisher
	Yang N, Wang Y, Hui L, Li X, Jiang X. SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway. Tumour Biol. 2015;36:8625-35 pubmed publisher
	Zhang J, Pan C, Xu T, Niu Z, Ma C, Xu C. Interleukin 18 augments growth ability via NF-κB and p38/ATF2 pathways by targeting cyclin B1, cyclin B2, cyclin A2, and Bcl-2 in BRL-3A rat liver cells. Gene. 2015;563:45-51 pubmed publisher
	Shi Y, Lu J, Zhou J, Tan X, He Y, Ding J, et al. Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. Biochem Biophys Res Commun. 2014;446:448-53 pubmed publisher
	Chen J, Shi D, Liu X, Fang S, Zhang J, Zhao Y. Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis. BMC Cancer. 2012;12:464 pubmed publisher
	Teng I, Chang Y, Wang L, Lu H, Wu L, Yang C, et al. Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer. Biomaterials. 2013;34:7462-70 pubmed publisher
	Wang Y, Wu H, Gao L, Chen S, Gu L, Ding Z, et al. Elevated toll-like receptor 3 inhibits pancreatic β-cell proliferation through G1 phase cell cycle arrest. Mol Cell Endocrinol. 2013;377:112-22 pubmed publisher
	Li M, Yu M, Liu C, Zhu H, He X, Peng S, et al. miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis. Cell Prolif. 2013;46:223-31 pubmed publisher
	Zhang H, Tan S, Wang J, Chen S, Quan J, Xian J, et al. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway. Exp Cell Res. 2014;320:119-27 pubmed publisher
	Souza L, Silva E, Calloway E, Kucuk O, Rossi M, McLemore M. Genistein protects hematopoietic stem cells against G-CSF-induced DNA damage. Cancer Prev Res (Phila). 2014;7:534-44 pubmed publisher
	Wang H, Yang Z, Liu C, Huang S, Wang H, Chen Y, et al. RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. Biochem Biophys Res Commun. 2014;454:71-7 pubmed publisher
	Lin C, Wang L, Wang H, Fang S, Zhang Q, Yang L, et al. Lithocarpus polystachyus REHD leaf aqueous extract inhibits human breast cancer growth in vitro and in vivo. Nutr Cancer. 2014;66:613-24 pubmed publisher
	Ye B, Li J, Li Z, Yang J, Niu T, Wang S. Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo. J Ethnopharmacol. 2014;153:258-67 pubmed publisher
	He X, Xiang H, Zong X, Yan X, Yu Y, Liu G, et al. CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro. Cancer Cell Int. 2014;14:130 pubmed publisher

product information

Catalog Number :

bs-0623R

Product Name :

Cyclin D1 Polyclonal Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

100 ul

List Price :

279.5 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat, Goat

Background :

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity).

ALTnames :

cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI32739; G1/S-specific cyclin-D1; Ccnd1

Immunogen :

70-120/295

Epitope :

KLH conjugated synthetic peptide derived from mouse Cyclin D1

Localization :

Cytoplasm, Nucleus

Purity :

Purified by Protein A.

Concentration :

1ug/ul

Storage :

Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

Uses :

WB, FCM, IHC-P, IF(IHC-P), IF(ICC)

Application Summary :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)