MMP-13 Polyclonal Antibody | Bioss bs-0575R product information

product summary

company name :

Bioss

product type :

antibody

product name :

MMP-13 Polyclonal Antibody

catalog :

bs-0575R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Yang J, Lu Y, Guo A. Platelet-rich plasma protects rat chondrocytes from interleukin-1?-induced apoptosis. Mol Med Rep. 2016;14:4075-4082 pubmed publisher
western blot; rat	Ma C, Wu G, Wang Z, Wang P, Wu L, Zhu G, et al. Effects of chronic sleep deprivation on the extracellular signal-regulated kinase pathway in the temporomandibular joint of rats. PLoS ONE. 2014;9:e107544 pubmed publisher
immunohistochemistry - paraffin section; rat	Luo Y, Zhang L, Wang W, Hu Q, Song H, Su Y, et al. Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. Bone. 2013;55:439-48 pubmed publisher
	Ou Z, Wang Y, Liu L, Li L, Yeh S, Qi L, et al. Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals. Oncotarget. 2015;6:26065-78 pubmed publisher
	Zhang C, Li X, Zhang T, Fu J, Cui X. Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload. Acta Pharmacol Sin. 2013;34:1301-9 pubmed publisher

product information

sku :

bs-0575R

name :

MMP-13 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

MMP-13

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

250-300/471

subcellular locations :

Extracellular, Secreted

source :

KLH conjugated synthetic peptide derived from human MMP13

gene id link :

Entrez Gene: 4322

swiss prot :

P45452

swiss prot link :

Swiss Prot: P45452

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

CLG3; MANDP1; MMP-13; Collagenase 3; Matrix metalloproteinase-13; MMP13

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage