product summary
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company name :
Bioss
product type :
antibody
product name :
Smad7 + Smad6 Polyclonal Antibody
catalog :
bs-0566R
quantity :
100 ul
price :
289.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Bioss product webpage
citations: 3
Published Application/Species/Sample/DilutionReference
  • western blot; rat
Yang Y, Ding S, Xu G, Chen F, Ding F. MicroRNA-15a inhibition protects against hypoxia/reoxygenation-induced apoptosis of cardiomyocytes by targeting mothers against decapentaplegic homolog 7. Mol Med Rep. 2017;15:3699-3705 pubmed publisher
  • western blot; rat
Liu W, Shi R, Yang W, Zhao N, Du Y, Zou Y, et al. Synchronous alteration pattern between serine-threonine kinase receptor-associated protein and Smad7 in pilocarpine-induced rats of epilepsy. Synapse. 2014;68:275-82 pubmed publisher
  • ELISA; human
Kou W, Hu G, Yao H, Wang X, Shen Y, Kang H, et al. Transforming growth factor-β1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment. Inflamm Res. 2013;62:283-9 pubmed publisher
product information
sku :
bs-0566R
name :
Smad7 + Smad6 Polyclonal Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
Smad7 + Smad6
modification :
Unmodified
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
1-50/426
subcellular locations :
Cytoplasm, Nucleus
source :
KLH conjugated synthetic peptide derived from human Smad7
gene id link :
Entrez Gene: 4092
swiss prot :
O15105
swiss prot link :
Swiss Prot: O15105
applications :
WB, ELISA, IHC-P, IF(IHC-P)
applications with dilutions :
WB(1:100-1000), ELISA(1:500-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Human, Mouse, Rat
size :
100 ul
price :
289.5 USD
background :
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
CRCS3; MADH7; MADH8; Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7
lead time :
3 to 5 business days.
more info or order :
Bioss product webpage
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.