CDK5 Polyclonal Antibody | Bioss bs-0559R product information

product summary

company name :

Bioss

product type :

antibody

product name :

CDK5 Polyclonal Antibody

catalog :

bs-0559R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat	Cao Y, Jia X, Wei Y, Liu M, Liu J, Li H. Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ_1-42. Evid Based Complement Alternat Med. 2016;2016:6840432 pubmed publisher
western blot; rat	Li S, Wang S, Guo Z, Huang N, Zhao F, Zhu M, et al. Protective effect of Xingnaojia formulation on rats with brain and liver damage caused by chronic alcoholism. Exp Ther Med. 2015;10:1643-1652 pubmed
western blot; mouse	Yin X, Qi Y, Ren M, Wang S, Jiang H, Feng H, et al. Roscovitine treatment caused impairment of fertilizing ability in mice. Toxicol Lett. 2015;237:200-9 pubmed publisher

product information

sku :

bs-0559R

name :

CDK5 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

CDK5

specificity :

This antibody will detect both isoform variants of this protein. Due to similar amino acid composition of this protein to CDK3 in human, there is a chance that this antibody will react with CDK3 in human, based on an 83% sequence similarity.

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

1-45/292

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from human CDK5

gene id link :

Entrez Gene: 1020

swiss prot :

Q00535

swiss prot link :

Swiss Prot: Q00535

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

PSSALRE; Cyclin-dependent-like kinase 5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit; CDK5; CDKN5

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage