CDK1 Polyclonal Antibody | Bioss bs-0542R product information

product summary

company name :

Bioss

product type :

antibody

product name :

CDK1 Polyclonal Antibody

catalog :

bs-0542R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human	Ghate N, Das A, Chaudhuri D, Panja S, Mandal N. Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio. Cell Death Discov. 2016;2:15062 pubmed publisher
western blot; human	Ghate N, Chaudhuri D, Sarkar R, Sajem A, Panja S, Rout J, et al. An antioxidant extract of tropical lichen, Parmotrema reticulatum, induces cell cycle arrest and apoptosis in breast carcinoma cell line MCF-7. PLoS ONE. 2013;8:e82293 pubmed publisher
western blot; human	Haolong C, Du N, Hongchao T, Yang Y, Wei Z, Hua Z, et al. Enterovirus 71 VP1 activates calmodulin-dependent protein kinase II and results in the rearrangement of vimentin in human astrocyte cells. PLoS ONE. 2013;8:e73900 pubmed publisher
	Dai H, Ye M, Peng M, Zhou W, Bai H, Xiao X, et al. Aptamer TY04 inhibits the growth of multiple myeloma cells via cell cycle arrest. Tumour Biol. 2014;35:7561-8 pubmed publisher

product information

sku :

bs-0542R

name :

CDK1 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

CDK1

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

250-297/297

subcellular locations :

Cytoplasm, Nucleus, Mitochondrion

source :

KLH conjugated synthetic peptide derived from mouse CDK1

gene id link :

Entrez Gene: 12534

swiss prot :

P11440

swiss prot link :

Swiss Prot: P11440

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

Cdc2; Cdc2a; p34; Cyclin-dependent kinase 1; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase; Cdkn1

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage