MMP-1 Polyclonal Antibody | Bioss bs-0463R product information

product summary

company name :

Bioss

product type :

antibody

product name :

MMP-1 Polyclonal Antibody

catalog :

bs-0463R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section, other

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Ding F, Wang J, Zhu G, Zhao H, Wu G, Chen L. Osteopontin stimulates matrix metalloproteinase expression through the nuclear factor-κB signaling pathway in rat temporomandibular joint and condylar chondrocytes.. Am J Transl Res. 2017;9:316-329 pubmed
immunohistochemistry - paraffin section; rat	Song H, Luo Y, Wang W, Li S, Yang K, Dai M, et al. Effects of alendronate on lumbar intervertebral disc degeneration with bone loss in ovariectomized rats.. Spine J. 2017;17:995-1003 pubmed publisher
immunohistochemistry - paraffin section; rat	Elkabir M, El-Zehery R, Mourad M, Soliman O, Helal M, Refai A, et al. Efficacy of azithromycin and metronidazole combined therapy on rats' gingival overgrowth induced by cyclosporine-A: An experimental animal study. J Oral Biol Craniofac Res. 2016;6:219-226 pubmed
other; rat	Mohamed N, El-Zehery R, Mourad M, Grawish M. Impact of three different mouthwashes on the incidence of gingival overgrowth induced by cyclosporine-A: a randomized controlled experimental animal study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120:346-56 pubmed publisher
immunohistochemistry - paraffin section; rat	Luo Y, Zhang L, Wang W, Hu Q, Song H, Zhang Y. The inhibitory effect of salmon calcitonin on intervertebral disc degeneration in an ovariectomized rat model. Eur Spine J. 2015;24:1691-701 pubmed publisher

product information

sku :

bs-0463R

name :

MMP-1 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

MMP-1

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

430-464/464

subcellular locations :

Secreted

source :

KLH conjugated synthetic peptide derived from rat MMP1

gene id link :

Entrez Gene: 300339

applications :

IHC-P, IF(IHC-P)

applications with dilutions :

IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

CLGN; CLG; 27 kDa interstitial collagenase; collagenase, fibroblast; Fibroblast collagenase; Interstitial collagenase; Matrix metallopeptidase 1 interstitial collagenase; Matrix metalloproteinase-1; Matrix metalloprotease 1; Matrix Metalloproteinase 1; MMP-1; MMP1; MMP1_HUMAN; OTTHUMP00000045866; MMP 1.

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage