Histone H3 Polyclonal Antibody | Bioss bs-0349R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Histone H3 Polyclonal Antibody

catalog :

bs-0349R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000; loading ...; fig 3d	Eckert M, Coscia F, Chryplewicz A, Chang J, Hernandez K, Pan S, et al. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. 2019;: pubmed publisher
western blot; human; loading ...; fig s6b	Qiu L, Wang M, Hu S, Ru X, Ren Y, Zhang Z, et al. Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor. Cancers (Basel). 2018;10: pubmed publisher
western blot; human	Joy M, Gau D, Castellucci N, Prywes R, Roy P. The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms. J Biol Chem. 2017;292:11777-11791 pubmed publisher
western blot; mouse	Shen H, Wu N, Liu Z, Zhao H, Zhao M. Epigallocatechin-3-gallate alleviates paraquat-induced acute lung injury and inhibits upregulation of toll-like receptors. Life Sci. 2017;170:25-32 pubmed publisher

product information

sku :

bs-0349R

name :

Histone H3 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Histone H3

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

90-136/136

subcellular locations :

Nucleus

source :

KLH conjugated synthetic peptide derived from human Histone H3

gene id link :

Entrez Gene: 3020

swiss prot :

P84243

swiss prot link :

Swiss Prot: P84243

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat, Pig

size :

100 ul

price :

289.5 USD

background :

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

H3F3; H3.3A; Histone H3.3; H3F3A; PP781

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage