RAGE Polyclonal Antibody | Bioss bs-0177R product information

product summary

company name :

Bioss

product type :

antibody

product name :

RAGE Polyclonal Antibody

catalog :

bs-0177R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, other

more info or order :

Bioss product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Fu J, Shi Q, Song X, Liu Z, Wang Y, Wang Y, et al. From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft. Toxicol Sci. 2016;153:303-15 pubmed publisher
western blot; rat	Sun Y, Liu L, Xue Y, Wang P. Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats. J Neurosci Res. 2015;93:666-77 pubmed publisher
other; rat	Zhu X, Yao Y, Zhang L, Dong N, Yu Y, Sheng Z. Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function. Acta Pharmacol Sin. 2014;35:1167-76 pubmed publisher
western blot; rat	Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, et al. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS ONE. 2012;7:e52013 pubmed publisher

product information

sku :

bs-0177R

name :

RAGE Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

RAGE

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

140-190/402

subcellular locations :

Extracellular

source :

KLH conjugated synthetic peptide derived from rat AGER

gene id link :

Entrez Gene: 81722

swiss prot :

Q63495

swiss prot link :

Swiss Prot: Q63495

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Rat

size :

100 ul

price :

289.5 USD

background :

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; Ager

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage