VEGFR1 Polyclonal Antibody | Bioss bs-0170R product information

product summary

company name :

Bioss

product type :

antibody

product name :

VEGFR1 Polyclonal Antibody

catalog :

bs-0170R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human	Liu Y, Zou J, Li B, Wang Y, Wang D, Hao Y, et al. RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells. Int J Mol Med. 2017;40:65-74 pubmed publisher
western blot; rat	Liu H, Wang J, Wang J, Wang P, Xue Y. Paeoniflorin attenuates Aβ1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-κB- and VEGF/Flt-1 signaling pathways. Brain Res. 2015;1618:149-58 pubmed publisher
	Cheng G, Xiang H, Yang G, Ma J, Zhao J. Direct Effects of Bevacizumab on Rat Conjunctival Fibroblast. Cell Biochem Biophys. 2015;73:45-50 pubmed publisher

product information

sku :

bs-0170R

name :

VEGFR1 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

VEGFR1

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

1160-1210/1333

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from rat VEGFR1

gene id link :

Entrez Gene: 54251

swiss prot :

P53767

swiss prot link :

Swiss Prot: P53767

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity).

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

VEGFR-1; Vascular endothelial growth factor receptor 1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase receptor FLT; Flt1; Vegfr1

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage