beta Amyloid 1-42 Polyclonal Antibody | Bioss bs-0107R product information

product summary

company name :

Bioss

product type :

antibody

product name :

beta Amyloid 1-42 Polyclonal Antibody

catalog :

bs-0107R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Bioss product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human	Vinothkumar G, Kedharnath C, Krishnakumar S, Sreedhar S, Preethikrishnan K, Dinesh S, et al. Abnormal amyloid ?42 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease. BBA Clin. 2017;8:20-27 pubmed publisher
immunohistochemistry - paraffin section; rat	Behairi N, Belkhelfa M, Rafa H, Labsi M, Deghbar N, Bouzid N, et al. All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats. J Neuroimmunol. 2016;300:21-29 pubmed publisher
immunohistochemistry - paraffin section; mouse	Li Y, Dai Y, Sun J, Xiang Y, Yang J, Dai S, et al. Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway. J Mol Neurosci. 2016;58:28-38 pubmed publisher
ELISA; human	Wang C, Wang Z. Studying the relationship between cell cycle and Alzheimer's disease by gold nanoparticle probes. Anal Biochem. 2015;489:32-7 pubmed publisher
western blot; rat	Tian Y, Guo S, Wu X, Ma L, Zhao X. Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats. Cell Mol Neurobiol. 2015;35:585-94 pubmed publisher
immunohistochemistry - paraffin section; mouse	Kang L, Li S, Xing Z, Li J, Su Y, Fan P, et al. Dihydrotestosterone treatment delays the conversion from mild cognitive impairment to Alzheimer's disease in SAMP8 mice. Horm Behav. 2014;65:505-15 pubmed publisher
immunohistochemistry; rat	Zhang Q, Gao T, Luo Y, Chen X, Gao G, Gao X, et al. Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease. PLoS ONE. 2012;7:e33722 pubmed publisher
immunohistochemistry - frozen section; human	Xiao A, He J, Wang Q, Luo Y, Sun Y, Zhou Y, et al. The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neurosci Bull. 2011;27:287-99 pubmed publisher

product information

sku :

bs-0107R

name :

beta Amyloid 1-42 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

beta Amyloid 1-42

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

672-713/770

subcellular locations :

Extracellular, Secreted

source :

KLH conjugated synthetic peptide of human beta-Amyloid(1-42)

gene id link :

Entrez Gene: 351

swiss prot :

P05067

swiss prot link :

Swiss Prot: P05067

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; Amyloid beta A4 protein; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; PreA4; Protease nexin-II; A4

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage