Caspase 3 Polyclonal Antibody | Bioss bs-0081R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Caspase 3 Polyclonal Antibody

catalog :

bs-0081R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

goat, human, mouse, rat, cow, pig, sheep, rabbit

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section, other

more info or order :

Bioss product webpage

citations: 61

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat	Kubatka P, Uramova S, Kello M, Kajo K, Kruzliak P, Mojzis J, et al. Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma. J Cell Mol Med. 2017;21:2837-2851 pubmed publisher
western blot; rat	Wang Y, Xuan L, Cui X, Wang Y, Chen S, Wei C, et al. Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes. PLoS ONE. 2017;12:e0173469 pubmed publisher
immunohistochemistry - paraffin section; rat	Abdel Hamid N, El Azab M, Moustafa Y. Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:379-395 pubmed publisher
immunohistochemistry - paraffin section; rat	Kubatka P, Kello M, Kajo K, Kruzliak P, VÃ½bohovÃ¡ D, MojÅ¾iÅ¡ J, et al. Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model. Eur J Nutr. 2017;56:1303-1316 pubmed publisher
immunohistochemistry - paraffin section; rabbit	Košútová P, Mikolka P, Balentova S, Adamkov M, Kolomaznik M, Calkovska A, et al. Intravenous dexamethasone attenuated inflammation and influenced apoptosis of lung cells in an experimental model of acute lung injury. Physiol Res. 2016;65:S663-S672 pubmed
western blot; pig	Zhao Y, Zhang W, Liu X, Zhang P, Hao Y, Li L, et al. Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. Sci Rep. 2016;6:37884 pubmed publisher
immunohistochemistry - paraffin section; sheep western blot; sheep; loading ...; fig 6e	Wang Y, Zhao Y, Yu S, Feng Y, Zhang H, Kou X, et al. Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis. Toxicol Appl Pharmacol. 2016;313:149-158 pubmed publisher
immunocytochemistry; mouse	Bozok Cetintaş V, Acikgoz E, Yigitturk G, Demir K, Oktem G, Tezcanli Kaymaz B, et al. Effects of flavopiridol on critical regulation pathways of CD133high/CD44high lung cancer stem cells. Medicine (Baltimore). 2016;95:e5150 pubmed
western blot; human	Yang J, Li G, Zhang K. Pro-survival effects by NF-?B, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer. Biomed Pharmacother. 2016;84:1078-1087 pubmed publisher
western blot; mouse	Huang C, Liu H, Gong X, Wu L, Wen B. Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. Oncol Rep. 2016;36:2705-2714 pubmed publisher
western blot; rat	Yang J, Lu Y, Guo A. Platelet-rich plasma protects rat chondrocytes from interleukin-1?-induced apoptosis. Mol Med Rep. 2016;14:4075-4082 pubmed publisher
western blot; rat	Zhang X, Yu H. Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression. Iran J Pharm Res. 2016;15:491-9 pubmed
immunohistochemistry - paraffin section; mouse	Chen Z, He N, Chen M, Zhao L, Li X. Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release. Acta Biomater. 2016;43:195-207 pubmed publisher
ELISA; human	Zhao J, Qiu Y, Tian C, Fan T. The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo. Exp Toxicol Pathol. 2016;68:409-17 pubmed publisher
immunohistochemistry - paraffin section; rat	Kassayová M, Bobrov N, Strojný L, Orendás P, Demečková V, Jendželovský R, et al. Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer. Anticancer Res. 2016;36:2719-28 pubmed
ELISA; human	Shan M, Fan T. Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway. Toxicol In Vitro. 2016;35:36-42 pubmed publisher
western blot; human	Gao H, Liu Y, Li K, Wu T, Peng J, Jing F. Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer. Am J Transl Res. 2016;8:1115-32 pubmed
western blot; human	Yoshinaga A, Kajiya N, Oishi K, Kamada Y, Ikeda A, Chigwechokha P, et al. NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation. Eur J Pharmacol. 2016;782:21-9 pubmed publisher
immunohistochemistry - paraffin section; rat immunocytochemistry; rat	Lin C, Kuo Y, Chen T, Chien C. Quercetin-Rich Guava (Psidium guajava) Juice in Combination with Trehalose Reduces Autophagy, Apoptosis and Pyroptosis Formation in the Kidney and Pancreas of Type II Diabetic Rats. Molecules. 2016;21:334 pubmed publisher
western blot; mouse; 1:200; fig 3	Liu Y, Su X, Hao J, Chen M, Liu W, Liao X, et al. Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice. Int J Mol Sci. 2016;17: pubmed publisher
western blot; human	Qu Z, Zou X, Zhang X, Sheng J, Wang Y, Wang J, et al. Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. Mol Med Rep. 2016;13:1336-44 pubmed publisher
immunohistochemistry - paraffin section; rat	Kubatka P, KapinovÃ¡ A, Kello M, Kruzliak P, Kajo K, VÃ½bohovÃ¡ D, et al. Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer. Eur J Nutr. 2016;55:955-65 pubmed publisher
western blot; rat	Lv R, Mao N, Wu J, Lu C, Ding M, Gu X, et al. Neuroprotective effect of allicin in a rat model of acute spinal cord injury. Life Sci. 2015;143:114-23 pubmed publisher
western blot; human; 1:1000; fig 3	Song G, Li Y, Lin L, Cao Y. Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways. Mol Med Rep. 2015;12:7615-22 pubmed publisher
western blot; human	Liu J, Che X, Chang S, Qiu G, He S, Fan L, et al. Î²-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation. World J Gastroenterol. 2015;21:9945-56 pubmed publisher
western blot; human	Ding Q, Chen Y, Zhang Q, Guo Y, Huang Z, Dai L, et al. 8â€‘bromoâ€‘7â€‘methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatinâ€‘sensitive and resistant ovarian cancer cells. Mol Med Rep. 2015;12:5100-8 pubmed publisher
western blot; rat	Han N, Yu L, Song Z, Luo L, Wu Y. Agmatine protects MÃ¼ller cells from high-concentration glucose-induced cell damage via N-methyl-D-aspartic acid receptor inhibition. Mol Med Rep. 2015;12:1098-106 pubmed publisher
western blot; mouse	Wang J, Lu M, Dai H, Zhang S, Wang H, Wei N. Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway. Braz J Med Biol Res. 2015;48:245-53 pubmed publisher
western blot; human	Fang C, Zhang J, Qi D, Fan X, Luo J, Liu L, et al. Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells. PLoS ONE. 2014;9:e115204 pubmed publisher
western blot; human	Gao H, Jiang Q, Han Y, Peng J, Wang C. shRNA-mediated EMMPRIN silencing inhibits human leukemic monocyte lymphoma U937 cell proliferation and increases chemosensitivity to adriamycin. Cell Biochem Biophys. 2015;71:827-35 pubmed publisher
western blot; human	Gao H, Jiang Q, Han Y, Peng J, Wang C. Hispidulin potentiates the antitumor effect of sunitinib against human renal cell carcinoma in laboratory models. Cell Biochem Biophys. 2015;71:757-64 pubmed publisher
immunohistochemistry - paraffin section; mouse	Luo X, Zhang H, Chen M, Wei J, Zhang Y, Li X. Antimetastasis and antitumor efficacy promoted by sequential release of vascular disrupting and chemotherapeutic agents from electrospun fibers. Int J Pharm. 2014;475:438-49 pubmed publisher
other; rat	Zhang B, Bian X, He P, Fu X, Higuchi K, Yang X, et al. The toxicity mechanisms of action of Aβ25-35 in isolated rat cardiac myocytes. Molecules. 2014;19:12242-57 pubmed publisher
western blot; human	Yao K, Xing H, Yang W, Liao A, Wu B, Li Y, et al. Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells. Tumour Biol. 2014;35:8023-31 pubmed publisher
western blot; mouse	Liu Y, Xue Q, Li X, Zhang J, Fu Z, Feng B, et al. Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin. Int J Biol Sci. 2014;10:448-56 pubmed publisher
western blot; human	Lin C, Wang L, Wang H, Fang S, Zhang Q, Yang L, et al. Lithocarpus polystachyus REHD leaf aqueous extract inhibits human breast cancer growth in vitro and in vivo. Nutr Cancer. 2014;66:613-24 pubmed publisher
western blot; human	Ye B, Li J, Li Z, Yang J, Niu T, Wang S. Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo. J Ethnopharmacol. 2014;153:258-67 pubmed publisher
western blot; rat	Guan J, Li H, Lv T, Chen D, Yuan Y, Qu S. Bone morphogenetic protein-7 (BMP-7) mediates ischemic preconditioning-induced ischemic tolerance via attenuating apoptosis in rat brain. Biochem Biophys Res Commun. 2013;441:560-6 pubmed publisher
western blot; mouse	Teng I, Chang Y, Wang L, Lu H, Wu L, Yang C, et al. Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer. Biomaterials. 2013;34:7462-70 pubmed publisher
western blot; goat	Li M, Yu M, Liu C, Zhu H, He X, Peng S, et al. miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis. Cell Prolif. 2013;46:223-31 pubmed publisher
immunohistochemistry - paraffin section; human	Ma X, Lv P, Ye S, Zhang Y, Li S, Kan C, et al. DT390-triTMTP1, a novel fusion protein of diphtheria toxin with tandem repeat TMTP1 peptide, preferentially targets metastatic tumors. Mol Pharm. 2013;10:115-26 pubmed publisher
immunocytochemistry; mouse	Wei G, Chen Y, Chen D, Lai X, Liu D, Deng R, et al. ?-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and A?PP/PS1 mice. J Alzheimers Dis. 2013;33:863-80 pubmed publisher
immunohistochemistry - paraffin section; rat	Wang G, Han B, Zhou H, Wu L, Wang Y, Jia G, et al. Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway. Apoptosis. 2013;18:28-42 pubmed publisher
western blot; cow	Rosenzweig D, Djap M, Ou S, Quinn T. Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. Osteoarthritis Cartilage. 2012;20:1591-602 pubmed publisher
immunohistochemistry - paraffin section; mouse western blot; mouse	Lei M, Bai X, Yang T, Lai X, Qiu W, Yang L, et al. Gsdma3 is a new factor needed for TNF-?-mediated apoptosis signal pathway in mouse skin keratinocytes. Histochem Cell Biol. 2012;138:385-96 pubmed publisher
immunohistochemistry - paraffin section; pig	Sun Y, Zhang J, Ping Z, Wang C, Sun Y, Chen L, et al. Relationship between apoptosis and proliferation in granulosa and theca cells of cystic follicles in sows. Reprod Domest Anim. 2012;47:601-8 pubmed publisher
	Kuriakose T, Zheng M, Neale G, Kanneganti T. IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018;200:1489-1495 pubmed publisher
	He N, Chen Z, Yuan J, Zhao L, Chen M, Wang T, et al. Tumor pH-Responsive Release of Drug-Conjugated Micelles from Fiber Fragments for Intratumoral Chemotherapy. ACS Appl Mater Interfaces. 2017;9:32534-32544 pubmed publisher
	Ochigbo G, Saba A, Oyagbemi A, Omobowale T, Asenuga E. Polyphenol-rich fraction of Parquetina nigrescens mitigates dichlorvos-induced neurotoxicity and apoptosis. J Ayurveda Integr Med. 2017;8:27-36 pubmed publisher
	Clark A, Coury E, Meilhac A, Petty H. WO3/Pt nanoparticles are NADPH oxidase biomimetics that mimic effector cells in vitro and in vivo. Nanotechnology. 2016;27:065101 pubmed publisher
	Dong L, Wang H, Niu J, Zou M, Wu N, Yu D, et al. Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1. Onco Targets Ther. 2015;8:3649-64 pubmed publisher
	Jia J, Dai S, Sun X, Sang Y, Xu Z, Zhang J, et al. A preliminary study of the effect of ECRG4 overexpression on the proliferation and apoptosis of human laryngeal cancer cells and the underlying mechanisms. Mol Med Rep. 2015;12:5058-64 pubmed publisher
	Tian A, Qin X, Wu A, Zhang H, Xu Q, Xing D, et al. Nanoscale TiO2 nanotubes govern the biological behavior of human glioma and osteosarcoma cells. Int J Nanomedicine. 2015;10:2423-39 pubmed publisher
	Xiao K, Zou W, Yang Z, Rehman Z, Ansari A, Yuan H, et al. The role of visfatin on the regulation of inflammation and apoptosis in the spleen of LPS-treated rats. Cell Tissue Res. 2015;359:605-618 pubmed publisher
	Pan B, Yang L, Wang J, Wang Y, Wang J, Zhou X, et al. C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis. Mol Neurobiol. 2014;49:1102-16 pubmed publisher
	Sondag G, Salihoglu S, Lababidi S, Crowder D, Moussa F, Abdelmagid S, et al. Osteoactivin induces transdifferentiation of C2C12 myoblasts into osteoblasts. J Cell Physiol. 2014;229:955-66 pubmed publisher
	Li T, Pang S, Yu Y, Wu X, Guo J, Zhang S. Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain. 2013;136:3578-88 pubmed publisher
	Li M, Yu M, Liu C, Zhu H, Hua J. Expression of miR-34c in response to overexpression of Boule and Stra8 in dairy goat male germ line stem cells (mGSCs). Cell Biochem Funct. 2013;31:281-8 pubmed publisher
	Aksu I, Ates M, Baykara B, Kiray M, Sisman A, Buyuk E, et al. Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes. Neurosci Lett. 2012;531:176-81 pubmed publisher
	Jiang J, Chen X, Chen X, Zheng S. Ginsenoside Rg3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway. World J Gastroenterol. 2011;17:3605-13 pubmed publisher
	Hu H, Kang J, Chen R, Mamuti W, Wu G, Yuan W. Drug-induced apoptosis of Echinococcus granulosus protoscoleces. Parasitol Res. 2011;109:453-9 pubmed publisher

product information

sku :

bs-0081R

name :

Caspase 3 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Caspase-3

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

60-100/277

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from human Caspase 3(Active)

gene id link :

Entrez Gene: 836

swiss prot :

P42574

swiss prot link :

Swiss Prot: P42574

applications :

WB, IHC-P, IF(IHC-P), IF(ICC)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

cross reactive species :

Human, Mouse, Rat, Bovine, Goat

size :

100 ul

price :

289.5 USD

background :

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

CPP32; SCA-1; CPP32B; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; CASP3

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage