Caspase 8 Polyclonal Antibody | Bioss bs-0052R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Caspase 8 Polyclonal Antibody

catalog :

bs-0052R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow, pig, sheep

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; human	Gao H, Liu Y, Li K, Wu T, Peng J, Jing F. Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer. Am J Transl Res. 2016;8:1115-32 pubmed
western blot; pig western blot; cow; loading ...; fig 1c	Zhao Y, Zhang W, Liu X, Zhang P, Hao Y, Li L, et al. Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. Sci Rep. 2016;6:37884 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5a	Daverey A, Agrawal S. Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes. Neuroscience. 2016;333:92-103 pubmed publisher
immunohistochemistry - paraffin section; sheep	Wang Y, Zhao Y, Yu S, Feng Y, Zhang H, Kou X, et al. Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis. Toxicol Appl Pharmacol. 2016;313:149-158 pubmed publisher
immunohistochemistry - paraffin section; rat	Wang G, Han B, Zhou H, Wu L, Wang Y, Jia G, et al. Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway. Apoptosis. 2013;18:28-42 pubmed publisher
western blot; human	Wu C, Tang Z, Jiang L, Li X, Jiang Z, Liu L. PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. Mol Cell Biochem. 2012;359:347-58 pubmed publisher
western blot; human	Fang C, Zhang J, Qi D, Fan X, Luo J, Liu L, et al. Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells. PLoS ONE. 2014;9:e115204 pubmed publisher
	Akinrinde A, Oyagbemi A, Omobowale T, Asenuga E, Ajibade T. Alterations in blood pressure, antioxidant status and caspase 8 expression in cobalt chloride-induced cardio-renal dysfunction are reversed by Ocimum gratissimum and gallic acid in Wistar rats. J Trace Elem Med Biol. 2016;36:27-37 pubmed publisher
	Tulsulkar J, Glueck B, Hinds T, Shah Z. Ginkgo biloba Extract Prevents Female Mice from Ischemic Brain Damage and the Mechanism Is Independent of the HO1/Wnt Pathway. Transl Stroke Res. 2016;7:120-31 pubmed publisher

product information

sku :

bs-0052R

name :

Caspase 8 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Caspase 8

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

430-482/482

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from mouse Caspase-8 subunit p10

gene id link :

Entrez Gene: 12370

swiss prot :

O89110

swiss prot link :

Swiss Prot: O89110

applications :

WB, IHC-P, IF(IHC-P), IF(ICC)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP1. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp- -AMC. Likely target for the cowpox virus CRMA death inhibitory protein.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

MACH; Mch5; FLICE; CASP-8; Caspase-8; Casp8

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage