ERK1 + ERK2 Polyclonal Antibody | Bioss bs-0022R product information

product summary

company name :

Bioss

product type :

antibody

product name :

ERK1 + ERK2 Polyclonal Antibody

catalog :

bs-0022R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow, pig

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human	Chu M, Zhao Y, Feng Y, Zhang H, Liu J, Cheng M, et al. MicroRNA-126 participates in lipid metabolism in mammary epithelial cells.. Mol Cell Endocrinol. 2017;454:77-86 pubmed publisher
western blot; rat	Du W, Su J, Ye D, Wang Y, Huang Q, Gong X. Pinellia ternata Attenuates Mucus Secretion and Airway Inflammation after Inhaled Corticosteroid Withdrawal in COPD Rats. Am J Chin Med. 2016;44:1027-41 pubmed publisher
western blot; pig western blot; cow; loading ...; fig 4	Zhao Y, Zhang W, Liu X, Zhang P, Hao Y, Li L, et al. Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. Sci Rep. 2016;6:37884 pubmed publisher
western blot; mouse; fig 3	Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, et al. Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice. Drug Des Devel Ther. 2015;9:6327-42 pubmed publisher
western blot; mouse	Sun J, Wang Y, Fu X, Chen Y, Wang D, Li W, et al. Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice. Biomed Res Int. 2015;2015:139451 pubmed publisher

product information

sku :

bs-0022R

name :

ERK1 + ERK2 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

ERK1 + ERK2

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

330-358/358

subcellular locations :

Cytoplasm, Nucleus

source :

KLH conjugated synthetic peptide derived from mouse ERK2

gene id link :

Entrez Gene: 26413

swiss prot :

P63085

swiss prot link :

Swiss Prot: P63085

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; Mapk1; Erk2; Mapk; Prkm1

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage