Sheep antibody to rh BDNF: IgG | Biosensis S-015-500 product information

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product summary

company name :

Biosensis

product type :

antibody

product name :

Sheep antibody to rh BDNF: IgG

catalog :

S-015-500

quantity :

500 µg

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry

product information

Catalog Number :

S-015-500

Product Name :

Sheep antibody to rh BDNF: IgG

Host Species :

Sheep

Clonality :

Polyclonal

Product Type :

Purified

Size :

500 µg

list of Pubmed id :

20613480, 19646438

Product Description :

BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

CrossReactivity :

Known to react with BDNF from rat and human.

ALTnames :

Brain-derived neurotrophic factor; Abrineurin; proBDNF;

Immunogen :

Recombinant human BDNF

Specificity :

A cross reactivity of less than 1% against mouse NGF, recombinant human NT3 or NT4/5 has been shown by one site ELISA.

Packaging :

Small box at room temperature

Application Summary :

IHC, ELISA, WB, inhibition of biological activity in vitro/in vivo. Recommended to be used at an amount of 1-10 µg/ml for immunohistochemistry, ELISA, Western blot or inhibition of biological activity in vitro. Use neat for in vivo studies at 2-10 µg/ml (ED50). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Storage :

After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Product References :

1. Hayashida K., Eisenach J.C.(2010) Spinal alpha2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function Anesthesiology. 2010 Aug;113(2):406-12. . 2. Geremia N.M. et al (2010) Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons Exp Neurol. 2010 May;223(1):128-42. .

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