Survivin (IAP) | BioLogo SUR002-G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLogo

product type :

antibody

product name :

Survivin (IAP)

catalog :

SUR002-G

quantity :

5 ml

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse

application :

immunohistochemistry - paraffin section

product information

Catalog Number :

SUR002-G

Product Name :

Survivin (IAP)

Host Species :

Rabbit

Product Type :

Primary Antibody

Size :

5 ml

List Price :

200 USD

Clone :

polyclonal

Isotype :

IgG

CrossReactivity :

Human, mouse, others not tested

Background :

Survivin, an inhibitor of apoptosis protein (IAP), is expressed in the G2/M phase of the cell cycle. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increases caspase3 activity, a mechanism involved in cell death, during mitosis. The overexpression of survivin in cancer may overcome this apoptosis checkpoint and favour aberrant progression of transformed cells through mitosis.

Immunogen :

Synthetic C-terminal peptide sequence of human Survivin

Specificity :

Human Survivin

Application Summary :

IHC(P)

Storage :

2-8°C

General References :

1. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997 Aug;3(8):917-21.

Product References :

2. Liggins C et al. (2003) Pediatric Dev. Pathol. 6: 392-397.