Podoplanin (PDPN, M2A Antigen) (D2-40) | BioLogo PDP001-0.5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLogo

product type :

antibody

product name :

Podoplanin (PDPN, M2A Antigen) (D2-40)

catalog :

PDP001-0.5

quantity :

0.5 ml

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D2-40

reactivity :

human

application :

immunohistochemistry

citations: 1

Reference
Suarez Carmona M, Hubert P, Gonzalez A, Duray A, Roncarati P, Erpicum C, et al. ?Np63 isoform-mediated ?-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma. Oncotarget. 2014;5:1856-68 pubmed

product information

Catalog Number :

PDP001-0.5

Product Name :

Podoplanin (PDPN, M2A Antigen) (D2-40)

Host Species :

Mouse

Product Type :

Primary Antibody

Size :

0.5 ml

List Price :

495 USD

Clone :

D2-40

Isotype :

IgG1

CrossReactivity :

Human, other species not tested

Background :

Podoplanin is a highly glycosylated glycoprotein (162 AS, 36 kDa) that is predominantly expressed on lymphatic endothelia. Therefore antibodies against podoplanin are often used as a marker for lymphatic vessels. Podoplanin is a protein that is also found on podocytes of the kidney glomeruli (therefore the name podoplanin) and in fetal testis. Since a while podoplanin is considered as a good marker for the malign pleuramesothelioma and is used for differential diagnosis of this disease (Ordonèz, 2005). Normally podoplanin occurs in lymphatic vessels, placenta, lung, and skeletal muscles. Appearance in testicular germ cells, lymphangioma and lymphangiosarcoma is noticeable. In haemangioma und other diseases of the vessels overexpression of the glycoprotein is not found.

Immunogen :

M2A Antigen, Podoplanin

Specificity :

Podoplanin, M2A Antigen of lymphatic endothelia

Application Summary :

IHC (C,P)

Storage :

2-8°C

General References :

1. Hiroaki Yokomori Masaya Oda, Fumihiko Kaneko, Shigeyuki Kawachi, Minoru Tanabe, Kazunori Yoshimura, Yuko Kitagawa, and Toshifumi Hibi Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver- Re-evaluations of microlymphatic abnormalities Gastroenterology 2010, 10:131

Product References :

2. Annette M. Müller, Folker E. Franke, Klaus-Michael Müller (2006) D2-40: A Reliable Marker in the Diagnosis of Pleural Mesothelioma Pathobiology 73:50-54