PAX-8 (Paired box protein 8) | BioLogo PAX008-0.5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLogo

product type :

antibody

product name :

PAX-8 (Paired box protein 8)

catalog :

PAX008-0.5

quantity :

0.5 ml

price :

460 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

ZR-1

reactivity :

Japanese rice, human, mouse, rat

application :

immunohistochemistry

product information

Catalog Number :

PAX008-0.5

Product Name :

PAX-8 (Paired box protein 8)

Host Species :

Rabbit

Product Type :

Primary Antibody

Size :

0.5 ml

List Price :

460 USD

Clone :

ZR-1

Isotype :

IgG

CrossReactivity :

Human, others not known

Background :

PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometroid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Studies have also found PAX-8 expression in renal tubules as well as renal carcinoma, nephroblastoma and seminoma. Over 98% of clear cell RCCs, 90% of papillary RCCs, and 95% of oncocytomas were positive for PAX-8, frequencies which are similar or better than for PAX-2. Normal lung and lung carcinomas do not express PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that PAX-8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities. PAX-8, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to differentiate the primary site of invasive micro-papillary carcinomas of ovary from those of the bladder, lung, and breast.

Immunogen :

Synthetic peptide corresponding to the C-terminus of Human PAX8 protein

Specificity :

PAX-8 protein

Application Summary :

IHC (C,P)

Storage :

2-8°C

General References :

1. Poleev A., Fickenscher H., Mundlos S., Winterpacht A., Zabel B., Fidler A., Gruss P., Plachov D. PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development 116:611-623(1992) [PubMed: 1337742]

Product References :

2. Kozmik Z., Kurzbauer R., Doerfler P., Busslinger M. "Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol. Cell. Biol. 13:6024-6035(1993) [PubMed: 8413205]