Beta-Catenin | BioLogo CTN001-G product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLogo

product type :

antibody

product name :

Beta-Catenin

catalog :

CTN001-G

quantity :

5 ml

price :

180 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

E247

reactivity :

human, mouse

application :

western blot, immunohistochemistry

product information

Catalog Number :

CTN001-G

Product Name :

Beta-Catenin

Host Species :

Rabbit

Product Type :

Primary Antibody

Size :

5 ml

List Price :

180 USD

Clone :

E247

Isotype :

IgG

CrossReactivity :

Human, Mouse, other species not tested

Background :

Beta-Catenin is a 88 kDa protein which is exprimed in many different tissues. Normally it is located in the cytoplasm near the cell membrane. It is associated with E-Cadherin and it may be essential for the function of this protein. Mutations in Beta-Catenin Gen CTNNBT1 lead to a loss of membrane binding and to an accumulation of the protein in the nuclear region. Nuclear accumulation is found especially in fibromatous lesions of the breast and abdomen. Therefore the antibody has been used for differentiation of these lesions from other spindle cell tumors, which may occur in the named body regions. Nuclear Accumulation of beta-Catenin was also found in colo-rectal carcinoma.

Immunogen :

Synthetic peptide corresponding to a N-terminal aa sequence of human ß-Catenin

Specificity :

Beta-Catenin (CTNB1); Catenin (Cadherin-associated Protein) beta 1

Application Summary :

IHC(C, P), WB

Storage :

2-8°C

General References :

1. Montgomery E, Torbenson MS, Kaushal M, Fisher C, Abraham SC.(2002) Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis. Am J Surg Pathol. 2002 Oct;26(10):1296-301.

Product References :

2. Montgomery E, Folpe AL. (2005) The diagnostic value of beta-catenin immunohistochemistry. Adv Anat Pathol. 2005 Nov;12(6):350-6.