CD34, human | BioLogo CD34-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLogo

product type :

antibody

product name :

CD34, human

catalog :

CD34-1

quantity :

1 ml

price :

290 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

QBEND/10

reactivity :

human, dog, cow

application :

immunohistochemistry - paraffin section

citations: 2

Reference
Sato Y, Ren X, Harada K, Sasaki M, Morikawa H, Shiomi S, et al. Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: possible link to serum anti-endothelial cell antibodies. Clin Exp Immunol. 2012;167:532-42 pubmed publisher
Sellheyer K, Krahl D. Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult human skin. J Am Acad Dermatol. 2010;63:93-113 pubmed publisher

product information

Catalog Number :

CD34-1

Product Name :

CD34, human

Host Species :

Mouse

Product Type :

Primary Antibody

Size :

1 ml

List Price :

290 USD

Clone :

QBEND/10

Isotype :

IgG1,k

CrossReactivity :

Human, Rhesus Monkey, no cross-reactivity with cattle, dog, rat and sheep

Background :

The CD34 molecule is a glycoprotein (110 kDa), which is expressed as well by endothelial cells as by haematopoietic precursor cells (BFU-E, CFU-GM, CFU-Meg, CFU-Eo, CFU-osteoclasts and CFU-blasts) in human bone marrow. CD34 is the earliest marker of colony building cells in bone marrow. The molecule is heavily glycosylated in the N-terminal extracellular region and therefore sensitive to neuraminidase (target of CD34 class I antibodies). This region is followed by a globular Cys-rich domain. The cytoplasmic portion of the molecule contains sites for proteinkinase C and tyrosine phosphorylation.

Immunogen :

Purified human endothelial vesicles

Specificity :

Human CD34 antigen (Epitope neuraminidase resistant , glycoprotease- and chymopapain-sensitive)

Concentration :

40 µg/ml

Application Summary :

IHC(P)

Storage :

2-8°C

General References :

1. Civin C.I., Strauss L.C., Brovall C., Fackler M.J. , Schwartz J.F., Shaper J.H. (1984) Antigenic analysis of haematopoesis. III. A hematopoetic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-Ia cells. J. Immunol. 133; 157-165.

Product References :

2. Civin C.I., Trischmann T.M., Fackler M.J., Bernstein I.D., Bühring H.J., Campos L., et al. (1989) M7.1. Report on the CD34 cluster workshop. In: Kapp W. et al. Eds. Leucocyte Typing IV. White Cell Differentiation Antigens. Oxford, New York, Tokyo: Oxford University Press pp. 818-825.