E-Cadherin (Uvomorulin) | BioLogo CA150 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLogo

product type :

antibody

product name :

E-Cadherin (Uvomorulin)

catalog :

CA150

quantity :

1 ml

price :

340 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SPM471

reactivity :

human

application :

immunohistochemistry

product information

Catalog Number :

CA150

Product Name :

E-Cadherin (Uvomorulin)

Host Species :

Mouse

Product Type :

Primary Antibody

Size :

1 ml

List Price :

340 USD

Clone :

SPM471

Isotype :

IgG2b

CrossReactivity :

Human

Background :

E-Cadherin (Uvomorulin, ARC-1) is a Ca2+-dependent trans-membrane protein, which plays an important role for the cell connection in epithelia. Ligands for E-Cadherin are catenins, which bind to actin filaments of the cyto-skeleton. The cell to cell adhesion during embryo genesis is dependent of the interrelation of these three components. Reduced expression of E-Cadherin in carcinoma has been discussed as a factor influencing tumour invasion and bad prognosis of cancer.

Immunogen :

Recombinant human Uvomorulin (Cadherin-E) aa 600-707

Specificity :

E-Cadherin 120 kDa

Concentration :

50 µg/ml

Application Summary :

IHC(C, P)

Storage :

2-8°C

General References :

1. Frixen U.H., et al. (1991) E-Cadherin-mediated cell-cell adhesion prevents invasivness of human carcinoma cells. J. Cell Biol. 113 ff.

Product References :

2. Umbas R. Schalken J.A., Aalders T.W., Carter B.S., Karthaus H.F.M., Schaafsma H.E., Debruyne F.M.J., and Isaacs W.B. (1992) Expression of the cellular adhesion molecule E-Cadherin is reduced or absent in high-grade prostate cancer. Cancer Res. 52; 5104-5109.