Purified anti-p63 (TA) | BioLegend 938102 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-p63 (TA)

catalog :

938102

quantity :

100 μg

price :

347 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TAp63-4.1

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

BioLegend product webpage

citations: 3

Reference
Chalmers F, Dusold J, Shaik J, Walsh H, Glick A. Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration. Dev Biol. 2022;485:9-23 pubmed publisher
Portal C, Wang Z, Scott D, Wolosin J, Iomini C. The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair. Invest Ophthalmol Vis Sci. 2022;63:3 pubmed publisher
Wu H, Wang B, Armstrong S, Abuetabh Y, Leng S, Roa W, et al. Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation. Nucleic Acids Res. 2021;49:2740-2758 pubmed publisher

product information

Antigen :

p63

Apps. Abbrev. :

WB, ICC, IP

Cat # :

938102

Clone :

TAp63-4.1

Item :

Purified anti-p63 (TA)

Isotype :

Mouse IgG2a, κ

Other Names :

TP63,Tumor Protein P63, P63, Transformation-Related Protein 63, Tumor Protein 63, P73L, Tumor Chronic Ulcerative Stomatitis Protein, Keratinocyte Transcription Factor KET, Protein P73-Like, Tumor Protein P53-Competing Protein

Size :

100 μg

Price (USD) :

347 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PURE

Immunogen :

Full-length recombinant human p63 (TA) protein

Application Notes :

Epitope binding of TAp63-4.1 has been mapped to the LSDPxW motif at the C-terminal region of the p63 transactivation (TA) domain (Nekulova M, et al. 2013. Virchows Arch. 463:415). Because this sequence is absent in the p63 (?N isoform) and the p63 paralog p73, this antibody is not predicted to react with either protein. Lack of p63 (?N) reactivity was confirmed during product development testing.This clone was ICC tested on Raji cells fixed with 4% PFA and permeabilized with either Triton X-100 or methanol. Both methods were compatible with p63 (TA) staining.This clone is predicted to recognize all p63 (TA) isoforms.This clone is predicted to recognize mouse p63 (TA) due to complete sequence conservation of the LSDPxW epitope between human and mouse p63 (TA) orthologs.;

more info or order :

BioLegend product webpage