Purified anti-CD243 (MDR-1) | BioLegend 907001 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified anti-CD243 (MDR-1)

catalog :

907001

quantity :

1 mL

price :

604 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C494

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

BioLegend product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:100; fig s1	Fanelli M, Hattinger C, Vella S, Tavanti E, Michelacci F, Gudeman B, et al. Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1Â® can Overcome Drug Resistance in Osteosarcoma. Curr Cancer Drug Targets. 2016;16:261-74 pubmed
	Er E, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018;20:966-978 pubmed publisher
	Martín Broto J, Gutiérrez A, Ramos R, Lopez Guerrero J, Ferrari S, Stacchiotti S, et al. MRP1 overexpression determines poor prognosis in prospectively treated patients with localized high-risk soft tissue sarcoma of limbs and trunk wall: an ISG/GEIS study. Mol Cancer Ther. 2014;13:249-59 pubmed publisher
	Mahadevan D, Unger J, Spier C, Persky D, Young F, LeBlanc M, et al. Phase 2 trial of combined cisplatin, etoposide, gemcitabine, and methylprednisolone (PEGS) in peripheral T-cell non-Hodgkin lymphoma: Southwest Oncology Group Study S0350. Cancer. 2013;119:371-9 pubmed publisher
	Villar V, Vögler O, Martínez Serra J, Ramos R, Calabuig Fariñas S, Gutierrez A, et al. Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas. PLoS ONE. 2012;7:e37735 pubmed publisher
	Beck W, Grogan T, Willman C, Cordon Cardo C, Parham D, Kuttesch J, et al. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res. 1996;56:3010-20 pubmed
	Lee J, Hughes C, Fine R, Page R. P-glycoprotein expression in canine lymphoma: a relevant, intermediate model of multidrug resistance. Cancer. 1996;77:1892-8 pubmed
	Rao V, Anthony D, Piwnica Worms D. MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase. Cancer Res. 1994;54:1536-41 pubmed

product information

Antigen :

CD243

Apps. Abbrev. :

IHC-P, ICC, IP, FC, WB

Cat # :

907001

Clone :

C494

Item :

Purified anti-CD243 (MDR-1)

Isotype :

Mouse IgG2a, κ

Other Names :

P-glycoprotein 1, ABC20, CLCS, GP170, MDR1, P-GP, PGY1, colchicin sensitivity, doxorubicin resistance, multidrug resistance protein 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, MRP1, Multidrug resistance protein 1

Size :

1 mL

Price (USD) :

604 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PURE

Application Notes :

This antibody is effective in immunoblotting, immunohistochemistry (IHC), immunocytochemistry (ICC) and immunopurification (IP).Positive Cell Lines: Drug-sensitive parental cell lines and their multidrug-resistant derivatives.Positive Tissues: Human liver (positive staining detected along luminal surfaces of bile canaliculi) or human colon (positive staining localized to luminal surface of secretaory epithelium).C494 detects a gene-specific, internal cellular epitope (PNTLEGN) present only on the Mdr1 isoform of P-glycoprotein. C494 does not cross react with Mdr3. C494 has been shown to cross-react with Pyruvate Carboxylase (PC), an abundant 130kDa mitochondrial enzyme, on both immunoblots and immunohistochemical tissue sections. Unequivocal plasma membrane patterns of immunostaining represent true P-glycoprotein expression. Weak homogeneous, cytoplasmic, or granular patterns of reactivity may represent staining of the PC cross-reactive epitope rather than positive staining for P-glycoprotein.;

more info or order :

BioLegend product webpage