Anti-CD243 (ABCB1, P-glycoprotein 1) | BioLegend 901401 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Anti-CD243 (ABCB1, P-glycoprotein 1)

catalog :

901401

quantity :

1 mL

price :

533 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

JSB-1

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 2

Reference
Liu H, Wang M, Liang N, Guan L. PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial‑mesenchymal transition. Mol Med Rep. 2019;19:2173-2179 pubmed publisher
Mahadevan D, Unger J, Spier C, Persky D, Young F, LeBlanc M, et al. Phase 2 trial of combined cisplatin, etoposide, gemcitabine, and methylprednisolone (PEGS) in peripheral T-cell non-Hodgkin lymphoma: Southwest Oncology Group Study S0350. Cancer. 2013;119:371-9 pubmed publisher

product information

Antigen :

CD243

Apps. Abbrev. :

IHC-P, ICC, Western Blotting, Flow Cytometry

Cat # :

901401

Clone :

JSB-1

Item :

Anti-CD243 (ABCB1, P-glycoprotein 1)

Isotype :

Mouse IgG1

Other Names :

P-glycoprotein 1, ABC20, CLCS, GP170, MDR1, P-GP, PGY1, colchicin sensitivity, doxorubicin resistance, multidrug resistance protein 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, MRP1, Multidrug resistance protein 1, P-glycoprotein 1

Size :

1 mL

Price (USD) :

533 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

TCS

Immunogen :

This antibody was raised against a multidrug-resistant Chinese hamster ovary cell line (CHrC5).

Application Notes :

This antibody is effective in immunoblotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry (FC). ICC Positive Cell Lines: Drug-sensitive parental cell lines and their multidrug-resistant derivatives. IHC Positive Tissue: Human liver (positive staining detected along luminal surfaces of bile canaliculi) or human colon (positive staining localized to luminal surface of secretaory epithelium). JSB-1 identifies an independent, strongly conserved cytoplasmic epitope present on the mammalian MDR1 P-glycoprotein molecule. JSB-1 does not cross-react with MDR3 P-glycoprotein. JSB-1 has been shown to cross-react with Pyruvate Carboxylase (PC), an abundant 130kDa mitochondrial enzyme, on both immunoblots and immunohistochemical tissue sections. Unequivocal plasma membrane patterns of immunostaining represent true P-glycoprotein expresssion. Weak homogeneous, cytoplasmic, or granular patterns of reactivity may represent staining of the PC cross-reactive epitope rather than positive staining for P-glycoprotein.