Anti-BACE1 (CO2 terminus) | BioLegend 840101 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Anti-BACE1 (CO2 terminus)

catalog :

840101

quantity :

100 μL

price :

419 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Poly8401

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Liu L, Ding L, Rovere M, Wolfe M, Selkoe D. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. J Cell Biol. 2019;218:644-663 pubmed publisher

product information

Antigen :

BACE1

Apps. Abbrev. :

WB, ICC, IP

Cat # :

840101

Clone :

Poly8401

Item :

Anti-BACE1 (CO2 terminus)

Isotype :

Rabbit Polyclonal IgG

Other Names :

Beta-Secretase 1, Asp 2, Memapsin-2, App Beta-Secretase, Aspartyl Protease 2, Beta-Site App Cleaving Enzyme 1, Beta-Secretase 1 Precursor Variant 1, Transmembrane Aspartic Proteinase Asp2, Membrane-Associated Aspartic Protease 2, Amyloid Beta A4

Size :

100 μL

Price (USD) :

419 USD

Reactivity :

Human, Mouse, Rat

Clonality :

Polyclonal

Host :

Rabbit

Conjugate/Tag/Label :

SERUM

Immunogen :

B690 was raised against a peptide sequence CLRQQHDDFADDISLLK , the C-terminal 17 amino acids of the human BACE1 and recognizes the mature and immature forms of BACE.

Application Notes :

This antibody is effective in immunoblotting, immunocytochemistry, (ICC) and immunoprecipitation (IP).Processing of the β-amyloid precursor protein (βAPP) by two endopeptidases, β and γ secretases generates the amyloidogenic peptide Aβ, a major factor in the etiology of Alzheimers disease. The beta secretase is a novel membrane bound aspartyl protease which cleaves the β-APP to generate the N-terminus of the Aβ domain. The membrane bound C-terminal fragment generated by the beta secretase cut is subsequently cleaved by the gamma secretase, resulting in the generation and secretion of Aβ.Clone also known as B690.;This product may contain other non-IgG subtypes.;