product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-Neurofilament Marker (pan axonal, cocktail)
catalog :
837904
quantity :
100 μg
price :
276 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SMI 312
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 154
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; 1:1000; loading ...; fig s5g
Yamada S, Mizukoshi T, Tokunaga A, Sakakibara S. Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development. PLoS Genet. 2022;18:e1010438 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 8b
Soto Faguás C, Sanchez Molina P, Saura C. Loss of presenilin function enhances tau phosphorylation and aggregation in mice. Acta Neuropathol Commun. 2021;9:162 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 6i
Pan X, Zhao J, Zhou Z, Chen J, Yang Z, Wu Y, et al. 5'-UTR SNP of FGF13 causes translational defect and intellectual disability. elife. 2021;10: pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 6i
Turner J, O Halloran J, Kalaidina E, Kim W, Schmitz A, Zhou J, et al. SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses. Nature. 2021;596:109-113 pubmed publisher
  • western blot; mouse; fig 2g
Pons V, Lévesque P, Plante M, Rivest S. Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. Alzheimers Res Ther. 2021;13:8 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 1b
Mehta A, Gregory J, Dando O, Carter R, Burr K, Nanda J, et al. Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis. Acta Neuropathol. 2021;141:257-279 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3c
Martinez L, Black K, Webb B, Bell A, Baygani S, Mier T, et al. Components of Endocannabinoid Signaling System Are Expressed in the Perinatal Mouse Cerebellum and Required for Its Normal Development. Eneuro. 2020;7: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5l, m
Shibahara T, Ago T, Nakamura K, Tachibana M, Yoshikawa Y, Komori M, et al. Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Eneuro. 2020;7: pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 5
Ostroff L, Santini E, SEARS R, Deane Z, Kanadia R, LeDoux J, et al. Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala. elife. 2019;8: pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 3a
Guo H, Li Y, Shen L, Wang T, Jia X, Liu L, et al. Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission. Sci Adv. 2019;5:eaax2166 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 1a
Octeau J, Gangwani M, Allam S, Tran D, Huang S, Hoang Trong T, et al. Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation. Cell Rep. 2019;27:2249-2261.e7 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:500; loading ...; fig 1b
Giandomenico S, Mierau S, Gibbons G, Wenger L, Masullo L, Sit T, et al. Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output. Nat Neurosci. 2019;22:669-679 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 6c
Aprile D, Fruscione F, Baldassari S, Fadda M, Ferrante D, Falace A, et al. TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons. Cell Death Differ. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 4a
Cheng W, Martens K, Bashir A, Cheung H, Stukas S, Gibbs E, et al. CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice. Alzheimers Res Ther. 2019;11:6 pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 5a`
Goulao M, Ghosh B, Urban M, Sahu M, Mercogliano C, Charsar B, et al. Astrocyte progenitor transplantation promotes regeneration of bulbospinal respiratory axons, recovery of diaphragm function, and a reduced macrophage response following cervical spinal cord injury. Glia. 2019;67:452-466 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5e'
  • western blot; mouse; loading ...; fig 5m
Saifetiarova J, Bhat M. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. J Neurosci Res. 2019;97:313-331 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 2a
Muñoz S, Li H, Ruberu K, Chu Q, Saghatelian A, Ooi L, et al. The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis. J Biol Chem. 2018;293:4071-4084 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 4(S1A)
Grove M, Kim H, Santerre M, Krupka A, Han S, Zhai J, et al. YAP/TAZ initiate and maintain Schwann cell myelination. elife. 2017;6: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 3,4
Rubovitch V, Zilberstein Y, Chapman J, Schreiber S, Pick C. Restoring GM1 ganglioside expression ameliorates axonal outgrowth inhibition and cognitive impairments induced by blast traumatic brain injury. Sci Rep. 2017;7:41269 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig s6b
Sellgren C, Sheridan S, Gracias J, Xuan D, Fu T, Perlis R. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol Psychiatry. 2017;22:170-177 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig s2
Saggu R, Schumacher T, Gerich F, Rakers C, Tai K, Delekate A, et al. Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia. Acta Neuropathol Commun. 2016;4:76 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig st1
Ku T, Swaney J, Park J, Albanese A, Murray E, Cho J, et al. Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. Nat Biotechnol. 2016;34:973-81 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 1
Li T, Braunstein K, Zhang J, Lau A, Sibener L, Deeble C, et al. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016;7:12082 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 1:4000; fig 3
Spitzbarth I, Lempp C, Kegler K, Ulrich R, Kalkuhl A, Deschl U, et al. Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis. Brain Behav. 2016;6:e00472 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 4a
Schulz A, Büttner R, Hagel C, Baader S, Kluwe L, Salamon J, et al. The importance of nerve microenvironment for schwannoma development. Acta Neuropathol. 2016;132:289-307 pubmed publisher
Zhang W, Fu Y, Peng L, Ogawa Y, Ding X, Rasband A, et al. Immunoproximity biotinylation reveals the axon initial segment proteome. Nat Commun. 2023;14:8201 pubmed publisher
So H, Kim H, Lee J, You C, Yun C, Jeong H, et al. Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss. Research (Wash D C). 2023;6:0158 pubmed publisher
Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, et al. CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue. BMC Biol. 2023;21:113 pubmed publisher
Abedin M, Michelhaugh S, Mittal S, Berdichevsky Y. 3D models of glioblastoma interaction with cortical cells. Front Bioeng Biotechnol. 2023;11:1150772 pubmed publisher
Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz Herranz A, Mayer C, et al. Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. J Clin Invest. 2023;133: pubmed publisher
Mendonsa S, von K xfc gelgen N, Dantsuji S, Ron M, Breimann L, Baranovskii A, et al. Massively parallel identification of mRNA localization elements in primary cortical neurons. Nat Neurosci. 2023;26:394-405 pubmed publisher
Unda B, Chalil L, Yoon S, Kilpatrick S, Irwin C, Xing S, et al. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Mol Psychiatry. 2023;: pubmed publisher
Junakovi x107 A, Kopi x107 J, Duque A, Rakic P, Krsnik x, Kostovi x107 I. Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Struct Funct. 2023;228:613-633 pubmed publisher
Su X, Ying J, Xiao D, Qiu X, Li S, Zhao F, et al. Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway. Int J Mol Med. 2023;51: pubmed publisher
Schwarzenberg F, Sch xfc tz P, Hammel J, Riedel M, Bartl J, Bordbari S, et al. Three-dimensional analyses of vascular network morphology in a murine lymph node by X-ray phase-contrast tomography with a 2D Talbot array. Front Immunol. 2022;13:947961 pubmed publisher
Lickfett S, Menacho C, Zink A, Telugu N, Beller M, Diecke S, et al. High-content analysis of neuronal morphology in human iPSC-derived neurons. STAR Protoc. 2022;3:101567 pubmed publisher
Olguin S, Patel P, Buchanan C, Dell Orco M, GARDINER A, Cole R, et al. KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization. Commun Biol. 2022;5:672 pubmed publisher
Eltahir M, Nakamori M, Hattori S, Kimura T, Mochizuki H, Nagano S. Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1. PLoS ONE. 2022;17:e0269683 pubmed publisher
Li P, Liu B, Wu X, Lu Y, Qiu M, Shen Y, et al. Perirenal adipose afferent nerves sustain pathological high blood pressure in rats. Nat Commun. 2022;13:3130 pubmed publisher
Chueh K, Huang K, Lu J, Juan T, Chuang S, Lin R, et al. Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model. Int J Mol Sci. 2022;23: pubmed publisher
Ichise M, Sakoori K, Katayama K, Morimura N, Yamada K, Ozawa H, et al. Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics. Front Mol Neurosci. 2022;15:856315 pubmed publisher
Ackermans N, Varghese M, Williams T, Grimaldi N, Selmanovic E, Alipour A, et al. Evidence of traumatic brain injury in headbutting bovids. Acta Neuropathol. 2022;144:5-26 pubmed publisher
Prieto Huarcaya S, Drobny A, Marques A, Di Spiezio A, Dobert J, Balta D, et al. Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models. Autophagy. 2022;18:1127-1151 pubmed publisher
Davies A, Alecu J, Ziegler M, Vasilopoulou C, Merciai F, Jumo H, et al. AP-4-mediated axonal transport controls endocannabinoid production in neurons. Nat Commun. 2022;13:1058 pubmed publisher
Renzini A, Marroncelli N, Cavioli G, Di Francescantonio S, Forcina L, Lambridis A, et al. Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy. J Cachexia Sarcopenia Muscle. 2022;13:1339-1359 pubmed publisher
Southam K, de Sousa C, Daniel A, Taylor B, Foa L, Premilovac D. Development and characterisation of a rat model that exhibits both metabolic dysfunction and neurodegeneration seen in type 2 diabetes. J Physiol. 2022;600:1611-1630 pubmed publisher
Castoldi V, Marenna S, Huang S, d Isa R, Chaabane L, Comi G, et al. Dose-dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis. J Neurosci Res. 2022;100:855-868 pubmed publisher
Silver xe5 Ejneby M, Jake x161 ov xe1 M, Ferrero J, Migliaccio L, Sahalianov I, Zhao Z, et al. Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor. Nat Biomed Eng. 2022;6:741-753 pubmed publisher
Scaricamazza S, Salvatori I, Amadio S, Nesci V, Torcinaro A, Giacovazzo G, et al. Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice. Br J Pharmacol. 2022;179:1732-1752 pubmed publisher
Yamada S, Sato A, Ishihara N, Akiyama H, Sakakibara S. Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development. iScience. 2021;24:103484 pubmed publisher
Chludzinski E, Puff C, Weber J, Hewicker Trautwein M. Case Report: Primary Diffuse Leptomeningeal Oligodendrogliomatosis in a Young Adult Cat. Front Vet Sci. 2021;8:795126 pubmed publisher
Huuskonen M, Liu Q, Lamorie Foote K, Shkirkova K, Connor M, Patel A, et al. Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion. Front Immunol. 2021;12:785519 pubmed publisher
Creighton B, Afriyie S, Ajit D, Casingal C, Voos K, Reger J, et al. Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A. elife. 2021;10: pubmed publisher
Hoffmann P, Giandomenico S, Ganeva I, Wozny M, Sutcliffe M, Lancaster M, et al. Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids. elife. 2021;10: pubmed publisher
Ban Y, Yu T, Feng B, Lorenz C, Wang X, Baker C, et al. Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex. Sci Adv. 2021;7:eabh2974 pubmed publisher
Ming Y, Abedin M, Tatic Lucic S, Berdichevsky Y. Microdevice for directional axodendritic connectivity between micro 3D neuronal cultures. Microsyst Nanoeng. 2021;7:67 pubmed publisher
OIsen T, Capurro A, x160 vent M, Pilati N, Large C, Hartell N, et al. Sparsely Distributed, Pre-synaptic Kv3 K+ Channels Control Spontaneous Firing and Cross-Unit Synchrony via the Regulation of Synaptic Noise in an Auditory Brainstem Circuit. Front Cell Neurosci. 2021;15:721371 pubmed publisher
Doron Mandel E, Koppel I, Abraham O, Rishal I, Smith T, Buchanan C, et al. The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization. EMBO J. 2021;40:e107158 pubmed publisher
Zhu Q, Chen L, Li Y, Huang M, Shao J, Li S, et al. Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells. Cell Rep. 2021;36:109639 pubmed publisher
Cheng C, Reis S, Adams E, Fass D, Angus S, Stuhlmiller T, et al. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Sci Rep. 2021;11:17029 pubmed publisher
Ben Haim L, Schirmer L, Zulji A, Sabeur K, Tiret B, Ribon M, et al. Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes. Glia. 2021;69:2812-2827 pubmed publisher
Olmsted Z, Stigliano C, Scimemi A, Wolfe T, Cibelli J, Horner P, et al. Transplantable human motor networks as a neuron-directed strategy for spinal cord injury. iScience. 2021;24:102827 pubmed publisher
Uyeda A, Quan L, Kato Y, Muramatsu N, Tanabe S, Sakai K, et al. Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination. Glia. 2021;: pubmed publisher
Wegscheid M, Anastasaki C, Hartigan K, Cobb O, Papke J, Traber J, et al. Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Rep. 2021;36:109315 pubmed publisher
Xie X, Wang S, Li M, Diao L, Pan X, Chen J, et al. α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. Nat Commun. 2021;12:4113 pubmed publisher
Connor M, Lamorie Foote K, Liu Q, Shkirkova K, Baertsch H, Sioutas C, et al. Nanoparticulate matter exposure results in white matter damage and an inflammatory microglial response in an experimental murine model. PLoS ONE. 2021;16:e0253766 pubmed publisher
Cousin M, Creighton B, Breau K, Spillmann R, Torti E, Dontu S, et al. Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome. Nat Genet. 2021;53:1006-1021 pubmed publisher
Kahriman A, Bouley J, Smith T, Bosco D, Woerman A, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature. Acta Neuropathol Commun. 2021;9:118 pubmed publisher
Al xe7 ada Morais S, Gon xe7 alves N, Moreno Juan V, Andres B, Ferreira S, Marques J, et al. Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation. Cereb Cortex. 2021;31:5652-5663 pubmed publisher
Proietti Onori M, Koene L, Schäfer C, Nellist M, de Brito van Velze M, Gao Z, et al. RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity. PLoS Biol. 2021;19:e3001279 pubmed publisher
Haytural H, Jordà Siquier T, Winblad B, Mulle C, Tjernberg L, Granholm A, et al. Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease. Brain Commun. 2021;3:fcab079 pubmed publisher
Kanaan N, Grabinski T. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Front Mol Neurosci. 2021;14:607303 pubmed publisher
Zhang R, He H, Yuan B, Wu Z, Wang X, Du Y, et al. An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development. Neurosci Bull. 2021;37:1091-1106 pubmed publisher
Wegmann S, DeVos S, Zeitler B, Marlen K, Bennett R, Pérez Rando M, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Sci Adv. 2021;7: pubmed publisher
Song J, Kang M, Park D, Park S, Lee S, Suh Y. Pathogenic GRM7 mutations associated with neurodevelopmental disorders impair axon outgrowth and presynaptic terminal development. J Neurosci. 2021;: pubmed publisher
Yeh S, Yu S, Chu H, Huang C, Tsao Y, Cheng C, et al. Pigment Epithelium-Derived Factor Peptide Promotes Corneal Nerve Regeneration: An In Vivo and In Vitro Study. Invest Ophthalmol Vis Sci. 2021;62:23 pubmed publisher
Kugler C, Thielscher C, Tambe B, Schwarz M, Halle A, Bradke F, et al. Epothilones Improve Axonal Growth and Motor Outcomes after Stroke in the Adult Mammalian CNS. Cell Rep Med. 2020;1:100159 pubmed publisher
Zhang S, Wang Y, Xu J, Kim B, Deng W, Guo F. HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling. J Neurosci. 2021;41:251-268 pubmed publisher
Lee C, Song D, Park C, Choi J, Kang G, Shin S, et al. Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus. Nat Commun. 2020;11:5772 pubmed publisher
Ming Y, Hasan M, Tatic Lucic S, Berdichevsky Y. Micro Three-Dimensional Neuronal Cultures Generate Developing Cortex-Like Activity Patterns. Front Neurosci. 2020;14:563905 pubmed publisher
Feng T, Yamashita T, Sasaki R, Tadokoro K, Matsumoto N, Hishikawa N, et al. Protective effects of edaravone on white matter pathology in a novel mouse model of Alzheimer's disease with chronic cerebral hypoperfusion. J Cereb Blood Flow Metab. 2021;41:1437-1448 pubmed publisher
Kao C, van Bruggen R, Kim J, Chen X, Chan C, Lee J, et al. Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nat Commun. 2020;11:5304 pubmed publisher
Michaels N, Lemmon K, Plemel J, Jensen S, Mishra M, Brown D, et al. Aging-Exacerbated Acute Axon and Myelin Injury Is Associated with Microglia-Derived Reactive Oxygen Species and Is Alleviated by the Generic Medication Indapamide. J Neurosci. 2020;40:8587-8600 pubmed publisher
Shen Y, Hua L, Yeh C, Shen L, Ying M, Zhang Z, et al. Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease. Theranostics. 2020;10:11794-11819 pubmed publisher
Rodriguez B, Vega Soto E, Kennedy C, Nguyen M, Cederna P, Larkin L. A tissue engineering approach for repairing craniofacial volumetric muscle loss in a sheep following a 2, 4, and 6-month recovery. PLoS ONE. 2020;15:e0239152 pubmed publisher
Seabra C, Aneichyk T, Erdin S, Tai D, de Esch C, Razaz P, et al. Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons. Mol Autism. 2020;11:45 pubmed publisher
Huang Y, Hsu C, Chiu H, Hsi P, Ho C, Lo W, et al. Actin waves transport RanGTP to the neurite tip to regulate non-centrosomal microtubules in neurons. J Cell Sci. 2020;133: pubmed publisher
Shao W, Yang J, He M, Yu X, Lee C, Yang Z, et al. Centrosome anchoring regulates progenitor properties and cortical formation. Nature. 2020;580:106-112 pubmed publisher
Qian X, Su Y, Adam C, Deutschmann A, Pather S, Goldberg E, et al. Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell. 2020;26:766-781.e9 pubmed publisher
Zhu X, Hatfield J, Sullivan J, Xu F, Van Nostrand W. Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy. J Neuroinflammation. 2020;17:78 pubmed publisher
Sundaramoorthy V, Green D, Locke K, O Brien C, Dearnley M, Bingham J. Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies. PLoS Pathog. 2020;16:e1008343 pubmed publisher
Novakova S, Rodriguez B, Vega Soto E, Nutter G, Armstrong R, Macpherson P, et al. Repairing Volumetric Muscle Loss in the Ovine Peroneus Tertius Following a 3-Month Recovery. Tissue Eng Part A. 2020;26:837-851 pubmed publisher
Fifield K, Vanderluit J. Rapid degeneration of neurons in the penumbra region following a small, focal ischemic stroke. Eur J Neurosci. 2020;52:3196-3214 pubmed publisher
Iannielli A, Ugolini G, Cordiglieri C, Bido S, Rubio A, Colasante G, et al. Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses. Cell Rep. 2019;29:4646-4656.e4 pubmed publisher
Palomo Guerrero M, Fadó R, Casas M, Pérez Montero M, Baena M, Helmer P, et al. Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. elife. 2019;8: pubmed publisher
Mendsaikhan A, Tooyama I, Bellier J, Serrano G, Sue L, Lue L, et al. Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun. 2019;7:215 pubmed publisher
Urban M, Ghosh B, Block C, Charsar B, Smith G, Wright M, et al. Protein Tyrosine Phosphatase σ Inhibitory Peptide Promotes Recovery of Diaphragm Function and Sprouting of Bulbospinal Respiratory Axons after Cervical Spinal Cord Injury. J Neurotrauma. 2020;37:572-579 pubmed publisher
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner J, Oldani S, et al. SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering. EMBO J. 2019;38:e101289 pubmed publisher
Byun H, Lee H, Liu H, Forrest D, Rudenko A, Kim I. Rorβ regulates selective axon-target innervation in the mammalian midbrain. Development. 2019;146: pubmed publisher
Wu F, Han B, Wu S, Yang L, Leng S, Li M, et al. Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p/TIPARP. J Neurosci. 2019;: pubmed publisher
Zhao W, Tan J, Zhu T, Ou J, Li Y, Shen L, et al. Rare inherited missense variants of POGZ associate with autism risk and disrupt neuronal development. J Genet Genomics. 2019;: pubmed publisher
Hamilton A, Forkert N, Yang R, Wu Y, Rogers J, Yong V, et al. Central nervous system targeted autoimmunity causes regional atrophy: a 9.4T MRI study of the EAE mouse model of Multiple Sclerosis. Sci Rep. 2019;9:8488 pubmed publisher
Fenske P, Grauel M, Brockmann M, Dorrn A, Trimbuch T, Rosenmund C. Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology. Sci Rep. 2019;9:4890 pubmed publisher
Rivell A, Petralia R, Wang Y, Clawson E, Moehl K, Mattson M, et al. Sonic hedgehog expression in the postnatal brain. Biol Open. 2019;: pubmed publisher
Domise M, Sauvé F, Didier S, Caillerez R, Bégard S, Carrier S, et al. Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process. Cell Death Dis. 2019;10:221 pubmed publisher
Christensen K, Beach T, Serrano G, Kanaan N. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta Neuropathol Commun. 2019;7:29 pubmed publisher
Tan C, Lu N, Wang C, Chen D, Sun N, Lyu H, et al. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4. Neuron. 2019;101:920-937.e13 pubmed publisher
Chander P, Kennedy M, Winckler B, Weick J. Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. Eneuro. 2019;6: pubmed publisher
Mendsaikhan A, Takeuchi S, Walker D, Tooyama I. Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin. Front Mol Neurosci. 2018;11:470 pubmed publisher
Qiang L, Piermarini E, Muralidharan H, Yu W, Leo L, Hennessy L, et al. Hereditary spastic paraplegia: gain-of-function mechanisms revealed by new transgenic mouse. Hum Mol Genet. 2019;28:1136-1152 pubmed publisher
Aiken J, Moore J, Bates E. TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity. Hum Mol Genet. 2019;28:1227-1243 pubmed publisher
Kubo A, Misonou H, Matsuyama M, Nomori A, Wada Kakuda S, Takashima A, et al. Distribution of endogenous normal tau in the mouse brain. J Comp Neurol. 2019;527:985-998 pubmed publisher
Wang N, Dhumale P, Chiang J, Püschel A. The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases. Sci Rep. 2018;8:15647 pubmed publisher
Chierto E, Simon A, Castoldi F, Meffre D, Cristinziano G, Sapone F, et al. Mechanical Stretch of High Magnitude Provokes Axonal Injury, Elongation of Paranodal Junctions, and Signaling Alterations in Oligodendrocytes. Mol Neurobiol. 2019;56:4231-4248 pubmed publisher
Jensen S, Michaels N, Ilyntskyy S, Keough M, Kovalchuk O, Yong V. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1?. Cell Rep. 2018;24:3167-3179 pubmed publisher
Lager A, Corradin O, Cregg J, Elitt M, Shick H, Clayton B, et al. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Nat Commun. 2018;9:3708 pubmed publisher
Persoon C, Moro A, Nassal J, Farina M, Broeke J, Arora S, et al. Pool size estimations for dense-core vesicles in mammalian CNS neurons. EMBO J. 2018;37: pubmed publisher
Emperador Melero J, Huson V, Van Weering J, Bollmann C, Fischer von Mollard G, Toonen R, et al. Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Nat Commun. 2018;9:3421 pubmed publisher
Duncan G, Manesh S, Hilton B, Assinck P, Liu J, Moulson A, et al. Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination. Nat Commun. 2018;9:3066 pubmed publisher
Partida G, Fasoli A, Fogli Iseppe A, Ogata G, Johnson J, Thambiaiyah V, et al. Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve. J Neurosci. 2018;38:8087-8105 pubmed publisher
Matsumura R, Yamamoto H, Hayakawa T, Katsurabayashi S, Niwano M, Hirano Iwata A. Dependence and Homeostasis of Membrane Impedance on Cell Morphology in Cultured Hippocampal Neurons. Sci Rep. 2018;8:9905 pubmed publisher
Welliver R, Polanco J, Seidman R, Sinha A, O Bara M, Khaku Z, et al. Muscarinic Receptor M3R Signaling Prevents Efficient Remyelination by Human and Mouse Oligodendrocyte Progenitor Cells. J Neurosci. 2018;38:6921-6932 pubmed publisher
Muñoz Galdeano T, Reigada D, Del Águila A, Velez I, Caballero López M, Maza R, et al. Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury. Front Cell Neurosci. 2018;12:164 pubmed publisher
Wischhof L, Gioran A, Sonntag Bensch D, Piazzesi A, Stork M, Nicotera P, et al. A disease-associated Aifm1 variant induces severe myopathy in knockin mice. Mol Metab. 2018;13:10-23 pubmed publisher
Cooper M, Menta B, Pérez Sánchez C, Jack M, Khan Z, Ryals J, et al. A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice. Exp Neurol. 2018;306:149-157 pubmed publisher
Caprariello A, Rogers J, Morgan M, Hoghooghi V, Plemel J, Koebel A, et al. Biochemically altered myelin triggers autoimmune demyelination. Proc Natl Acad Sci U S A. 2018;115:5528-5533 pubmed publisher
Christiansen E, Yang S, Ando D, Javaherian A, Skibinski G, Lipnick S, et al. In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images. Cell. 2018;173:792-803.e19 pubmed publisher
Pallebage Gamarallage M, Foxley S, Menke R, Huszar I, Jenkinson M, Tendler B, et al. Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology. BMC Neurosci. 2018;19:11 pubmed publisher
Leung J, Bennett W, King A, Chung R. The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration. J Neuroinflammation. 2018;15:56 pubmed publisher
Urban M, Ghosh B, Strojny L, Block C, Blazejewski S, Wright M, et al. Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI. Exp Neurol. 2018;303:108-119 pubmed publisher
Beckmann N, Giorgetti E, Neuhaus A, Zurbruegg S, Accart N, Smith P, et al. Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945. Acta Neuropathol Commun. 2018;6:9 pubmed publisher
Hines T, Gao X, Sahu S, Lange M, Turner J, Twiss J, et al. An Essential Postdevelopmental Role for Lis1 in Mice. Eneuro. 2018;5: pubmed publisher
Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed publisher
Robinson S, Corbett C, Winer J, Chan L, Maxwell J, Anstine C, et al. Neonatal erythropoietin mitigates impaired gait, social interaction and diffusion tensor imaging abnormalities in a rat model of prenatal brain injury. Exp Neurol. 2018;302:1-13 pubmed publisher
Izadi M, Schlobinski D, Lahr M, Schwintzer L, Qualmann B, Kessels M. Cobl-like promotes actin filament formation and dendritic branching using only a single WH2 domain. J Cell Biol. 2018;217:211-230 pubmed publisher
Domínguez N, van Weering J, Borges R, Toonen R, Verhage M. Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B. J Neurochem. 2018;144:241-254 pubmed publisher
Plemel J, Michaels N, Weishaupt N, Caprariello A, Keough M, Rogers J, et al. Mechanisms of lysophosphatidylcholine-induced demyelination: A primary lipid disrupting myelinopathy. Glia. 2017;: pubmed publisher
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, et al. RNA localization is a key determinant of neurite-enriched proteome. Nat Commun. 2017;8:583 pubmed publisher
Geerts C, Mancini R, Chen N, Koopmans F, Li K, Smit A, et al. Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains. PLoS ONE. 2017;12:e0180912 pubmed publisher
Efimova N, Korobova F, Stankewich M, Moberly A, Stolz D, Wang J, et al. ?III Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. J Neurosci. 2017;37:6442-6459 pubmed publisher
Santos T, Wierda K, Broeke J, Toonen R, Verhage M. Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25. J Neurosci. 2017;37:4525-4539 pubmed publisher
Weber R, Chan C, Nie X, Maggioncalda E, Valiulis G, Lauer A, et al. Sensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia. NMR Biomed. 2017;30: pubmed publisher
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann A, et al. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proc Natl Acad Sci U S A. 2017;114:E2243-E2252 pubmed publisher
Li Q, Vo H, Wang J, Fox Quick S, Dobrunz L, King G. Klotho regulates CA1 hippocampal synaptic plasticity. Neuroscience. 2017;347:123-133 pubmed publisher
Dang T, Duan W, Yu B, Tong D, Cheng C, Zhang Y, et al. Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development. Mol Psychiatry. 2018;23:747-758 pubmed publisher
Kim S, Im S, Oh S, Jeong S, Yoon E, Lee C, et al. Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network. Nat Commun. 2017;8:14346 pubmed publisher
Claus L, Philippot C, Griemsmann S, Timmermann A, Jabs R, Henneberger C, et al. Barreloid Borders and Neuronal Activity Shape Panglial Gap Junction-Coupled Networks in the Mouse Thalamus. Cereb Cortex. 2018;28:213-222 pubmed publisher
Wang X, Studholme C, Grigsby P, Frias A, Cuzon Carlson V, Kroenke C. Folding, But Not Surface Area Expansion, Is Associated with Cellular Morphological Maturation in the Fetal Cerebral Cortex. J Neurosci. 2017;37:1971-1983 pubmed publisher
Michailidou I, Naessens D, Hametner S, Guldenaar W, Kooi E, Geurts J, et al. Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis. Glia. 2017;65:264-277 pubmed publisher
Zigler J, Hodgkinson C, Wright M, Klise A, Sundin O, Broman K, et al. A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems. PLoS ONE. 2016;11:e0160447 pubmed publisher
Schulz A, Büttner R, Toledo A, Baader S, von Maltzahn J, Irintchev A, et al. Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration. PLoS ONE. 2016;11:e0159718 pubmed publisher
Li H, Zhao P, Xu Q, Shan S, Hu C, Qiu Z, et al. The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1. Sci Rep. 2016;6:29878 pubmed publisher
Shah B, Lutter D, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, et al. Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex. Cereb Cortex. 2017;27:1253-1269 pubmed publisher
Choi Y, Di Nardo A, Kramvis I, Meikle L, Kwiatkowski D, Sahin M, et al. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 2008;22:2485-95 pubmed publisher
product information
Antigen :
Neurofilament Marker
Apps. Abbrev. :
IHC-P, WB, EM, ICC, IHC-F
Cat # :
837904
Clone :
SMI 312
Item :
Purified anti-Neurofilament Marker (pan axonal, cocktail)
Isotype :
Mouse IgG1/Mouse IgM
Other Names :
SMI-312, SMI312
Size :
100 μg
Price (USD) :
276 USD
Reactivity :
Human, Mouse, Rat
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
Homogenized hypothalami recovered from Fischer 344 rats.
Application Notes :
Additional reported applications (for the relevant formats) include: immunocytochemistry^1, 6, 12, 16, 19, immunofluorescent staining^3, 8, 9, 18.SMI 312 is a mixture of monoclonal antibodies that react against complex networks of axons. It is directed against extensively phosphorylated axonal epitopes on neurofilaments M and H. SMI 312 has been selected to provide a specific marker for axons in tissue sections and cultures. In contrast to individual anti-phosphoneurofilament antibodies that identify different subsets of neurofilament phosphoepitopes, which are suitable for defining functional and regional differences in normal and pathologic axons, SMI 312 is a convenient marker for axons in general. SMI 312 visualizes axons in an area-specific maturation pattern in human fetal brain. The antibody cocktail defines nuclear borderlines and is useful in establishing early connectivity with SMI 311, anti-neurofilament (not phosphorylated) identified dendrites. SMI 312 visualizes aberrantly sprouting axons in neuritic plaques derived from cortico-cortical fibers in Alzheimer's disease and identifies loss of synaptic circuitry proposed to be the basis of memory.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA