product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-Myelin Basic Protein
catalog :
836504
quantity :
100 μg
price :
276 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SMI 94
reactivity :
African green monkey, human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 58
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 2e
Li T, Sun Y, Zhang S, Xu Y, Li K, Xie C, et al. AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury. Mol Neurobiol. 2022;59:6613-6631 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 1a
Wang Y, Xu Y, Zhou K, Zhang S, Wang Y, Li T, et al. Autophagy Inhibition Reduces Irradiation-Induced Subcortical White Matter Injury Not by Reducing Inflammation, but by Increasing Mitochondrial Fusion and Inhibiting Mitochondrial Fission. Mol Neurobiol. 2022;59:1199-1213 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 3e
Li T, Li K, Zhang S, Wang Y, Xu Y, Cronin S, et al. Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice. Cell Death Dis. 2020;11:77 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig s6a
  • western blot; mouse; 1:1000; loading ...; fig s6a
Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres Benito L, Mendoza Ferreira N, et al. Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological. Front Mol Neurosci. 2019;12:19 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...; fig 2a
Hu X, Das B, Hou H, He W, Yan R. BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions. J Exp Med. 2018;215:927-940 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 10h
Bando Y, Hagiwara Y, Suzuki Y, Yoshida K, Aburakawa Y, Kimura T, et al. Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis. Glia. 2018;66:359-378 pubmed publisher
  • immunocytochemistry; African green monkey; 1:100; fig 3A
  • western blot; African green monkey; fig 3C
Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, et al. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. PLoS ONE. 2017;12:e0171947 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1b
Lim E, Nakanishi S, Hoghooghi V, Eaton S, Palmer A, Frederick A, et al. AlphaB-crystallin regulates remyelination after peripheral nerve injury. Proc Natl Acad Sci U S A. 2017;114:E1707-E1716 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:2000; loading ...; fig 2E1
  • western blot; mouse; 1:1000; loading ...; fig 5E
Grove M, Kim H, Santerre M, Krupka A, Han S, Zhai J, et al. YAP/TAZ initiate and maintain Schwann cell myelination. elife. 2017;6: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 3f
Hussain R, Macklin W. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017;37:397-412 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig s5
  • western blot; mouse; 1:2000; loading ...; fig 1a
Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, et al. The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying. PLoS Genet. 2016;12:e1006463 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 3
  • immunocytochemistry; mouse; 1:500; fig 5
Du C, Duan Y, Wei W, Cai Y, Chai H, Lv J, et al. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination. Nat Commun. 2016;7:11120 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; fig 1
  • western blot; mouse; 1:1000; fig s3
Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree J, et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci. 2015;18:674-82 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; fig 3
Kelly E, Opanashuk L, Majewska A. The effects of postnatal exposure to low-dose bisphenol-A on activity-dependent plasticity in the mouse sensory cortex. Front Neuroanat. 2014;8:117 pubmed publisher
  • western blot; human; 1:1000; fig 5
Boczonadi V, Müller J, Pyle A, Munkley J, Dor T, Quartararo J, et al. EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nat Commun. 2014;5:4287 pubmed publisher
Taniguchi M, Yasukochi S, Yamakawa W, Tsurudome Y, Tsuruta A, Horiguchi M, et al. Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice. Mol Pharmacol. 2023;104:73-79 pubmed publisher
Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, et al. CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue. BMC Biol. 2023;21:113 pubmed publisher
Zhang S, Li W, Xu Y, Li T, Ek J, Zhang X, et al. Alpha1-antitrypsin protects the immature mouse brain following hypoxic-ischemic injury. Front Cell Neurosci. 2023;17:1137497 pubmed publisher
Chuang Y, Alcantara A, Fabris G, Abderezaei J, Lu T, Melendez Vasquez C, et al. Myelination dictates axonal viscoelasticity. Eur J Neurosci. 2023;57:1225-1240 pubmed publisher
Gray J, Fern xe1 ndez Su xe1 rez M, Falah M, Smith D, Smith C, Kaya E, et al. Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse model. EBioMedicine. 2022;86:104374 pubmed publisher
Murakami Y, Hosomi R, Nishimoto A, Nishiyama T, Yoshida M, Fukunaga K. Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice. Nutrients. 2022;14: pubmed publisher
Acheta J, Bhatia U, Haley J, Hong J, Rich K, Close R, et al. Piezo channels contribute to the regulation of myelination in Schwann cells. Glia. 2022;70:2276-2289 pubmed publisher
S xe1 nchez de la Torre A, Aguado T, Huerga G xf3 mez A, Santamar xed a S, Gentile A, Chara J, et al. Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice. Cell Death Dis. 2022;13:585 pubmed publisher
Meyer Zu Reckendorf S, Moser D, Blechschmidt A, Joga V, Sinske D, Hegler J, et al. Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury. J Neurosci. 2022;42:2474-2491 pubmed publisher
Terry B, Park R, Cho S, Crino P, Kim S. Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex. Hum Mol Genet. 2022;31:1979-1996 pubmed publisher
Munot P, McCrea N, Torelli S, Manzur A, Sewry C, Chambers D, et al. TRAPPC11-related muscular dystrophy with hypoglycosylation of alpha-dystroglycan in skeletal muscle and brain. Neuropathol Appl Neurobiol. 2022;48:e12771 pubmed publisher
Carpena N, Chang S, Choi J, Jung J, Lee M. Wnt Modulation Enhances Otic Differentiation by Facilitating the Enucleation Process but Develops Unnecessary Cardiac Structures. Int J Mol Sci. 2021;22: pubmed publisher
Aguado T, Huerga G xf3 mez A, S xe1 nchez de la Torre A, Resel E, Chara J, Matute C, et al. Δ9 -Tetrahydrocannabinol promotes functional remyelination in the mouse brain. Br J Pharmacol. 2021;178:4176-4192 pubmed publisher
Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, et al. Synaptic disruption and CREB-regulated transcription are restored by K+ channel blockers in ALS. EMBO Mol Med. 2021;13:e13131 pubmed publisher
Skoff R, Bessert D, Banerjee S, Luo X, Thummel R. Characterization of the Expression of Vacuolar Protein Sorting 11 (Vps11) in Mammalian Oligodendrocytes. ASN Neuro. 2021;13:17590914211009851 pubmed publisher
Reiche L, G xf6 ttle P, Lane L, Duek P, Park M, Azim K, et al. C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage?. Front Cell Neurosci. 2021;15:653075 pubmed publisher
Huang H, Ho C, Sung H, Lee L, Chen W, Chen Y, et al. Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein. Sci Rep. 2021;11:6551 pubmed publisher
Huerga G xf3 mez A, Aguado T, S xe1 nchez de la Torre A, Bernal Chico A, Matute C, Mato S, et al. Δ9 -Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo. Glia. 2021;69:532-545 pubmed publisher
Reed C, Frick L, Weaver A, Sidoli M, Schlant E, Feltri M, et al. Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury. J Neurosci. 2020;40:6165-6176 pubmed publisher
Mukherjee C, Kling T, Russo B, Miebach K, Kess E, Schifferer M, et al. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metab. 2020;32:259-272.e10 pubmed publisher
Rui Y, Pollitt S, Myers K, Feng Y, Zheng J. Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store Operated Ca2+ Entry and Release. Eneuro. 2020;: pubmed publisher
Gravina G, Svedin P, Ardalan M, Levy O, Ek C, Mallard C, et al. Staphylococcus epidermidis Sensitizes Perinatal Hypoxic-Ischemic Brain Injury in Male but Not Female Mice. Front Immunol. 2020;11:516 pubmed publisher
van der Veeken L, Gr xf6 nlund S, Gerdtsson E, Holmqvist B, Deprest J, Ley D, et al. Long-term neurological effects of neonatal caffeine treatment in a rabbit model of preterm birth. Pediatr Res. 2020;87:1011-1018 pubmed publisher
Gail Canter R, Huang W, Choi H, Wang J, Ashley Watson L, Yao C, et al. 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Commun Biol. 2019;2:360 pubmed publisher
Wang Y, Zhou K, Li T, Xu Y, Xie C, Sun Y, et al. Selective Neural Deletion of the Atg7 Gene Reduces Irradiation-Induced Cerebellar White Matter Injury in the Juvenile Mouse Brain by Ameliorating Oligodendrocyte Progenitor Cell Loss. Front Cell Neurosci. 2019;13:241 pubmed publisher
Li K, Li T, Wang Y, Xu Y, Zhang S, Culmsee C, et al. Sex differences in neonatal mouse brain injury after hypoxia-ischemia and adaptaquin treatment. J Neurochem. 2019;150:759-775 pubmed publisher
Sung H, Chen W, Huang H, Wang C, Chang S, Tzeng S. Down-regulation of interleukin-33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression. J Neurochem. 2019;150:691-708 pubmed publisher
Rivera F, de la Fuente A, Zhao C, Silva M, González G, Wodnar R, et al. Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination. Glia. 2019;67:1510-1525 pubmed publisher
Iglesias J, Crampsie S, Strand C, Tachrount M, Thomas D, Holton J. Effect of Fluorinert on the Histological Properties of Formalin-Fixed Human Brain Tissue. J Neuropathol Exp Neurol. 2018;77:1085-1090 pubmed publisher
Mao Q, Nguyen P, Shanti R, Shi S, Shakoori P, Zhang Q, et al. GMSC-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration. Tissue Eng Part A. 2018;: pubmed publisher
Bruce K, Gorkhali S, Given K, Coates A, Boyle K, Macklin W, et al. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018;11:57 pubmed publisher
Praet J, Manyakov N, Muchene L, Mai Z, Terzopoulos V, De Backer S, et al. Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology. Alzheimers Res Ther. 2018;10:1 pubmed publisher
Albertsson A, Zhang X, Vontell R, Bi D, Bronson R, Supramaniam V, et al. γδ T Cells Contribute to Injury in the Developing Brain. Am J Pathol. 2018;188:757-767 pubmed publisher
Ahrendsen J, HARLOW D, Finseth L, Bourne J, Hickey S, Gould E, et al. The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination. J Neurosci. 2018;38:787-802 pubmed publisher
Stößel M, Rehra L, Haastert Talini K. Reflex-based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery-The 7-mm rat median nerve gap repair model revisited. Brain Behav. 2017;7:e00813 pubmed publisher
Thom M, Liu J, Bongaarts A, Reinten R, Paradiso B, Jäger H, et al. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?. Brain Pathol. 2018;28:155-171 pubmed publisher
Miyamoto Y, Torii T, Tanoue A, Yamauchi J. VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination. Nat Commun. 2016;7:13478 pubmed publisher
Fernando R, Cotter L, Perrin Tricaud C, Berthelot J, Bartolami S, Pereira J, et al. Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nat Commun. 2016;7:12186 pubmed publisher
Southwood C, Fykkolodziej B, Maheras K, Garshott D, Estill M, Fribley A, et al. Overexpression of CHOP in Myelinating Cells Does Not Confer a Significant Phenotype under Normal or Metabolic Stress Conditions. J Neurosci. 2016;36:6803-19 pubmed publisher
Shi Y, Shu J, Liang Z, Yuan S, Tang S. EXPRESS: Oligodendrocytes in HIV-associated pain pathogenesis. Mol Pain. 2016;12: pubmed publisher
Domènech Estévez E, Baloui H, MENG X, Zhang Y, Deinhardt K, Dupree J, et al. Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS. J Neurosci. 2016;36:4506-21 pubmed publisher
Maurel P, Einheber S, Galinska J, Thaker P, Lam I, Rubin M, et al. Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. J Cell Biol. 2007;178:861-74 pubmed
Zanazzi G, Einheber S, Westreich R, Hannocks M, Bedell Hogan D, Marchionni M, et al. Glial growth factor/neuregulin inhibits Schwann cell myelination and induces demyelination. J Cell Biol. 2001;152:1289-99 pubmed
product information
Antigen :
Myelin Basic Protein
Apps. Abbrev. :
IHC-P, WB, ICC, IHC-F
Cat # :
836504
Clone :
SMI 94
Item :
Purified anti-Myelin Basic Protein
Isotype :
Mouse IgG1, κ
Other Names :
Golli-MBP, myelin A1 protein, myelin membrane encephalitogenic protein
Size :
100 μg
Price (USD) :
276 USD
Reactivity :
Human, Mouse, Rat
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Application Notes :
SMI 94 reacts with the Myelin Basic Protein (MBP) peptic fragment 70-89 of the classic human myelin basic protein sequence.SMI 94 detects developing and adult myelin, developing oligodendrocytes and distinguishes oligodendrocytes from astrocytes, microglia, neurons and other cells in brain sections. The combination of SMI 94 with SMI 91 and/or 99 is useful for immunocytochemical studies on the progression of normal and pathologic myelination.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA