product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Alexa Fluor® 647 anti-Myelin CNPase
catalog :
836408
quantity :
100 μg
price :
323 USD
clonality :
monoclonal
host :
mouse
conjugate :
AF647
clone name :
SMI 91
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 11
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:700; loading ...; fig 2bi
Papazian I, Tsoukala E, Boutou A, Karamita M, Kambas K, Iliopoulou L, et al. Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. J Neuroinflammation. 2021;18:222 pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 3i
Moyon S, Frawley R, Maréchal D, Huang D, Marshall Phelps K, Kegel L, et al. TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice. Nat Commun. 2021;12:3359 pubmed publisher
Lavaert M, Liang K, Vandamme N, Park J, Roels J, Kowalczyk M, et al. Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes. Immunity. 2020;52:1088-1104.e6 pubmed publisher
Bergner C, van der Meer F, Winkler A, Wrzos C, Türkmen M, Valizada E, et al. Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia. 2019;67:1196-1209 pubmed publisher
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, et al. Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. Acta Neuropathol Commun. 2019;7:14 pubmed publisher
Martin N, Molnar V, Szilagyi G, Elkjaer M, Nawrocki A, Okarmus J, et al. Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice. Front Immunol. 2018;9:490 pubmed publisher
Hill R, Li A, Grutzendler J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nat Neurosci. 2018;21:683-695 pubmed publisher
Zrzavy T, Machado Santos J, Christine S, Baumgartner C, Weiner H, Butovsky O, et al. Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain Pathol. 2017;: pubmed publisher
Karamita M, Barnum C, Mobius W, TANSEY M, Szymkowski D, Lassmann H, et al. Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia. JCI Insight. 2017;2: pubmed publisher
Samanta J, Alden T, Gobeske K, Kan L, Kessler J. Noggin protects against ischemic brain injury in rodents. Stroke. 2010;41:357-62 pubmed publisher
Werner H, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, et al. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci. 2007;27:7717-30 pubmed
product information
Antigen :
Myelin CNPase
Apps. Abbrev. :
IHC-P
Cat # :
836408
Clone :
SMI 91
Item :
Alexa Fluor® 647 anti-Myelin CNPase
Isotype :
Mouse IgG1, κ
Other Names :
CNPase, Cnp-1, Cnp1, 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Size :
100 μg
Price (USD) :
323 USD
Reactivity :
Human, Rat, Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
A647
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue sections^1,2,4,8 (IHC), immunocytochemistry^5,6 (ICC), and western blot (WB).^3,7;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA