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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-Myelin CNPase
catalog :
836404
quantity :
100 μg
price :
276 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SMI 91
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 32
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:700; loading ...; fig 2bi
Papazian I, Tsoukala E, Boutou A, Karamita M, Kambas K, Iliopoulou L, et al. Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. J Neuroinflammation. 2021;18:222 pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 3i
Moyon S, Frawley R, Maréchal D, Huang D, Marshall Phelps K, Kegel L, et al. TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice. Nat Commun. 2021;12:3359 pubmed publisher
  • immunocytochemistry; rat; 1:200; loading ...; fig 5a
Stojic A, Bojcevski J, Williams S, Bas Orth C, Nessler S, Linington C, et al. Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. Glia. 2019;67:512-524 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:5000; loading ...; fig 5k
Rahman A, Weber J, Labin E, Lai C, Prieto A. Developmental expression of Neuregulin-3 in the rat central nervous system. J Comp Neurol. 2019;527:797-817 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 1a
Medina Rodríguez E, Bribian A, Boyd A, Palomo V, Pastor J, Lagares A, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017;7:43545 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4f
Larabee C, Desai S, Agasing A, Georgescu C, Wren J, Axtell R, et al. Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis. Mol Vis. 2016;22:1503-1513 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2e
  • western blot; mouse; 1:1000; loading ...; fig 3
Yoo S, Motari M, Schnaar R. Agenesis of the corpus callosum in Nogo receptor deficient mice. J Comp Neurol. 2017;525:291-301 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200; fig s2d
Figueres Oñate M, López Mascaraque L. Adult Olfactory Bulb Interneuron Phenotypes Identified by Targeting Embryonic and Postnatal Neural Progenitors. Front Neurosci. 2016;10:194 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5a
Larabee C, Hu Y, Desai S, Georgescu C, Wren J, Axtell R, et al. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice. Mol Vis. 2016;22:332-41 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:2500; fig 2
Larabee C, Georgescu C, Wren J, Plafker S. Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons. BMC Neurosci. 2015;16:76 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig s3
Lutz S, Zhao Y, Gulinello M, Lee S, Raine C, Brosnan C. Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation. J Neurosci. 2009;29:7743-52 pubmed publisher
Dustin E, Suárez Pozos E, Stotesberry C, Qiu S, Palavicini J, Han X, et al. Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion. Biomedicines. 2023;11: pubmed publisher
Ritzel R, Li Y, Jiao Y, Lei Z, Doran S, He J, et al. Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration. Sci Adv. 2023;9:eadd1101 pubmed publisher
Jablonska B, Adams K, Kratimenos P, Li Z, Strickland E, Haydar T, et al. Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia. Nat Commun. 2022;13:4771 pubmed publisher
Kato Y, Tago K, Fukatsu S, Okabe M, Shirai R, Oizumi H, et al. CRISPR/CasRx-Mediated RNA Knockdown Reveals That ACE2 Is Involved in the Regulation of Oligodendroglial Cell Morphological Differentiation. Noncoding RNA. 2022;8: pubmed publisher
Zhao X, Zhang M, Liu Y, Liu H, Ren K, Xue Q, et al. Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro. iScience. 2021;24:103485 pubmed publisher
Schwabenland M, Salié H, Tanevski J, Killmer S, Lago M, Schlaak A, et al. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity. 2021;54:1594-1610.e11 pubmed publisher
Li A, Hill R, Grutzendler J. Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons. Cereb Cortex. 2021;31:4340-4356 pubmed publisher
Huang S, Lu Q, Choi M, Zhang X, Kim J. Applying real-time monitoring of circadian oscillations in adult mouse brain slices to study communications between brain regions. STAR Protoc. 2021;2:100416 pubmed publisher
Huerga G xf3 mez A, Aguado T, S xe1 nchez de la Torre A, Bernal Chico A, Matute C, Mato S, et al. Δ9 -Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo. Glia. 2021;69:532-545 pubmed publisher
Chew L, Ming X, McEllin B, Dupree J, Hong E, Catron M, et al. Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and Repair. Cell Rep. 2019;29:3173-3186.e7 pubmed publisher
Shi Y, Manis M, Long J, Wang K, Sullivan P, Remolina Serrano J, et al. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med. 2019;216:2546-2561 pubmed publisher
Bergner C, van der Meer F, Winkler A, Wrzos C, Türkmen M, Valizada E, et al. Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia. 2019;67:1196-1209 pubmed publisher
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, et al. Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. Acta Neuropathol Commun. 2019;7:14 pubmed publisher
Martín López E, Meller S, Greer C. Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies. Brain Struct Funct. 2018;223:4067-4085 pubmed publisher
Martin N, Molnar V, Szilagyi G, Elkjaer M, Nawrocki A, Okarmus J, et al. Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice. Front Immunol. 2018;9:490 pubmed publisher
Hill R, Li A, Grutzendler J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nat Neurosci. 2018;21:683-695 pubmed publisher
Zrzavy T, Machado Santos J, Christine S, Baumgartner C, Weiner H, Butovsky O, et al. Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain Pathol. 2017;: pubmed publisher
Karamita M, Barnum C, Mobius W, TANSEY M, Szymkowski D, Lassmann H, et al. Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia. JCI Insight. 2017;2: pubmed publisher
Michailidou I, Naessens D, Hametner S, Guldenaar W, Kooi E, Geurts J, et al. Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis. Glia. 2017;65:264-277 pubmed publisher
Samanta J, Alden T, Gobeske K, Kan L, Kessler J. Noggin protects against ischemic brain injury in rodents. Stroke. 2010;41:357-62 pubmed publisher
Werner H, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, et al. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci. 2007;27:7717-30 pubmed
product information
Antigen :
Myelin CNPase
Apps. Abbrev. :
IHC-P, WB
Cat # :
836404
Clone :
SMI 91
Item :
Purified anti-Myelin CNPase
Isotype :
Mouse IgG1, κ
Other Names :
CNPase, Cnp-1, Cnp1, 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Size :
100 μg
Price (USD) :
276 USD
Reactivity :
Human, Rat, Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Application Notes :
Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue sections^1,2,4,8 (IHC), immunocytochemistry^5,6 (ICC), and western blot (WB).^3,7;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA