Purified (azide-free) anti-FMRP | BioLegend 834702 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified (azide-free) anti-FMRP

catalog :

834702

quantity :

25 μL

price :

106 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5C2

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

BioLegend product webpage

citations: 4

Reference
Kalinowska M, van der Lei M, Kitiashvili M, Mamcarz M, Oliveira M, Longo F, et al. Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome. Mol Autism. 2022;13:29 pubmed publisher
Raj N, McEachin Z, Harousseau W, Zhou Y, Zhang F, Merritt Garza M, et al. Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis. Cell Rep. 2021;35:108991 pubmed publisher
Graef J, Wu H, Ng C, Sun C, Villegas V, Qadir D, et al. Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons. Eur J Neurosci. 2020;51:2143-2157 pubmed publisher
Liu X, Wu H, Krzisch M, Wu X, Graef J, Muffat J, et al. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell. 2018;172:979-992.e6 pubmed publisher

product information

Antigen :

FMRP

Apps. Abbrev. :

WB, IHC-P, ICC

Cat # :

834702

Clone :

5C2

Item :

Purified (azide-free) anti-FMRP

Isotype :

Mouse IgG1, κ

Other Names :

Fragile X mental retardation protein 1, POF, FMRP, POF1, FRAXA

Size :

25 μL

Price (USD) :

106 USD

Reactivity :

Human, Mouse

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PUREAF

Immunogen :

This monoclonal antibody was raised against a recombinant protein isolated from baculovirus expressing mouse FMRP.

Application Notes :

This antibody is effective in immunoblotting (WB), immunohistochemistry on formalin-fixed paraffin-embedded tissue (IHC-P) and immunocytochemistry (ICC).The epitope for 5C2 lies between amino acids 347-353 of FMRP. This clone does not cross react with FXR1 or FXR2.;

more info or order :

BioLegend product webpage