product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified (azide-free) anti-TDP43 Phospho (Ser409/410)
catalog :
829901
quantity :
100 μL
price :
363 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
1D3/TDP-43
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
more info or order :
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3a
Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 7e
  • western blot; human; 1:500; loading ...; fig s5a
Gasset Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019;102:339-357.e7 pubmed publisher
Keating S, Bademosi A, San Gil R, Walker A. Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cell Mol Life Sci. 2023;80:95 pubmed publisher
Latimer C, Melief E, Ariza Torres J, Howard K, Keen A, Keene L, et al. Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue. Methods Mol Biol. 2023;2561:3-30 pubmed publisher
Gleixner A, Verdone B, Otte C, Anderson E, Ramesh N, Shapiro O, et al. NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nat Commun. 2022;13:3380 pubmed publisher
Ackermans N, Varghese M, Williams T, Grimaldi N, Selmanovic E, Alipour A, et al. Evidence of traumatic brain injury in headbutting bovids. Acta Neuropathol. 2022;144:5-26 pubmed publisher
Melikyan Z, Corrada M, Leiby A, Sajjadi S, Bukhari S, Montine T, et al. Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study. Neurobiol Aging. 2022;116:12-15 pubmed publisher
Liu E, Mori E, Hamasaki F, Lieberman A. TDP-43 proteinopathy occurs independently of autophagic substrate accumulation and underlies nuclear defects in Niemann-Pick C disease. Neuropathol Appl Neurobiol. 2021;47:1019-1032 pubmed publisher
Wiesner D, Tar L, Linkus B, Chandrasekar A, Olde Heuvel F, Dupuis L, et al. Reversible induction of TDP-43 granules in cortical neurons after traumatic injury. Exp Neurol. 2018;299:15-25 pubmed publisher
Kotfis K, Zegan Barańska M, Szydłowski Ł, Zukowski M, Ely E. Methods of pain assessment in adult intensive care unit patients - Polish version of the CPOT (Critical Care Pain Observation Tool) and BPS (Behavioral Pain Scale). Anaesthesiol Intensive Ther. 2017;49:66-72 pubmed publisher
Walker A, Daniels C, Goldman J, Trojanowski J, Lee V, Messing A. Astrocytic TDP-43 pathology in Alexander disease. J Neurosci. 2014;34:6448-58 pubmed publisher
Lippa C, Rosso A, Stutzbach L, Neumann M, Lee V, Trojanowski J. Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome. Arch Neurol. 2009;66:1483-8 pubmed publisher
Dormann D, Capell A, Carlson A, Shankaran S, Rodde R, Neumann M, et al. Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem. 2009;110:1082-94 pubmed publisher
Neumann M, Kwong L, Lee E, Kremmer E, Flatley A, Xu Y, et al. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol. 2009;117:137-49 pubmed publisher
product information
Antigen :
TDP43 Phospho Ser409/410
Apps. Abbrev. :
WB, IHC, ICC, ELISA
Cat # :
829901
Clone :
1D3/TDP-43
Item :
Purified (azide-free) anti-TDP43 Phospho (Ser409/410)
Isotype :
Rat IgG2a
Other Names :
TAR DNA-binding protein-43, TDP 43, TARDBP, ALS10
Size :
100 μL
Price (USD) :
363 USD
Reactivity :
Human, Rat
Clonality :
Monoclonal
Host :
Rat
Conjugate/Tag/Label :
PUREAF
Immunogen :
This antibody was raised against a phosphopeptide corresponding to: i) the C-terminal domain of human TDP43; and ii) inclusive of phosphorylated serine residues 409 and 410.
Application Notes :
This antibody is effective in immunoblotting (WB)Positive Control: Rat Brain nuclear lysateExpected MW: about 43 kD;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA