product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-α-Synuclein Phospho (Ser129)
catalog :
825702
quantity :
25 μL
price :
129 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P-syn/81A
reactivity :
human, mouse, roundworm
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 43
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; roundworm ; fig 5j
Park H, Choi D, Park J, Sim C, Park S, Kang S, et al. Scalable and Isotropic Expansion of Tissues with Simply Tunable Expansion Ratio. Adv Sci (Weinh). 2019;6:1901673 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:3000; loading ...; fig 2b
Ham S, Kim H, Yoon J, Kim H, Song B, Choi J, et al. Therapeutic Evaluation of Synthetic Peucedanocoumarin III in an Animal Model of Parkinson's Disease. Int J Mol Sci. 2019;20: pubmed publisher
Masato A, Plotegher N, Terrin F, Sandre M, Faustini G, Thor A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023;9:42 pubmed publisher
Li Y, Wang T, Meng L, Jin L, Liu C, Liang Y, et al. Novel naturally occurring autoantibodies attenuate α-synuclein pathology in a mouse model of Parkinson's disease. Neuropathol Appl Neurobiol. 2023;49:e12860 pubmed publisher
Dadgar Kiani E, Bieri G, Melki R, Gitler A, Lee J. Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics. Cell Rep. 2022;41:111631 pubmed publisher
Yuan X, Yang Y, Liu C, Tian Y, Xia D, Liu Z, et al. Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration. Mov Disord. 2022;37:1817-1830 pubmed publisher
Kim H, Maeng H, Kim J, Yoon J, Oh Y, Paek S, et al. Synthetic Peucedanocoumarin IV Prevents α-Synuclein Neurotoxicity in an Animal Model of Parkinson's Disease. Int J Mol Sci. 2022;23: pubmed publisher
Magalh xe3 es P, Lashuel H. Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies. NPJ Parkinsons Dis. 2022;8:93 pubmed publisher
Creed R, Memon A, Komaragiri S, Barodia S, Goldberg M. Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function. Acta Neuropathol Commun. 2022;10:78 pubmed publisher
Park H, Kam T, Peng H, Chou S, Mehrabani Tabari A, Song J, et al. PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease. Cell. 2022;185:1943-1959.e21 pubmed publisher
Saveri P, Magri S, Maderna E, Balistreri F, Lombardi R, Ciano C, et al. DNAJB2-related Charcot-Marie-Tooth disease type 2: Pathomechanism insights and phenotypic spectrum widening. Eur J Neurol. 2022;29:2056-2065 pubmed publisher
Cai W, Srivastava P, Feng D, Lin Y, Vanderburg C, Xu Y, et al. Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. Mol Neurodegener. 2022;17:16 pubmed publisher
Yoon Y, You J, Kim T, Ahn W, Kim M, Son K, et al. Senescence and impaired DNA damage responses in alpha-synucleinopathy models. Exp Mol Med. 2022;54:115-128 pubmed publisher
Yan M, Xiong M, Dai L, Zhang X, Zha Y, Deng X, et al. Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson's disease. NPJ Parkinsons Dis. 2022;8:1 pubmed publisher
Giannoccaro M, Avoni P, Rizzo G, Incensi A, Infante R, Donadio V, et al. Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome. J Parkinsons Dis. 2022;12:585-591 pubmed publisher
Yuan X, Yang Y, Xia D, Meng L, He M, Liu C, et al. Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson's Disease Pathology. Front Neurosci. 2021;15:807988 pubmed publisher
Zhang C, Zhao M, Wang B, Su Z, Guo B, Qin L, et al. The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease. Redox Biol. 2021;47:102134 pubmed publisher
Chung C, Chan L, Chen J, Hung Y, Hong C. Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson's Disease. Biomolecules. 2021;11: pubmed publisher
Stykel M, Humphries K, Kamski Hennekam E, Buchner Duby B, Porte Trachsel N, Ryan T, et al. α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology. Cell Rep. 2021;35:109099 pubmed publisher
Zhu G, Harischandra D, Ghaisas S, Zhang P, Prall W, Huang L, et al. TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Cell Rep. 2020;33:108418 pubmed publisher
Kim H, Shin J, Lee Y, Yun S, Maeng H, Lee Y. Brain Endothelial P-Glycoprotein Level Is Reduced in Parkinson's Disease via a Vitamin D Receptor-Dependent Pathway. Int J Mol Sci. 2020;21: pubmed publisher
Dastidar S, Pham M, Mitchell M, Yeom S, Jordan S, Chang A, et al. 4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response. J Neurosci. 2020;40:8734-8745 pubmed publisher
Creed R, Goldberg M. Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils. Neuroscience. 2020;437:64-75 pubmed publisher
Stoyka L, Arrant A, Thrasher D, Russell D, Freire J, Mahoney C, et al. Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions. Neurobiol Dis. 2020;134:104708 pubmed publisher
Cuddy L, Wani W, Morella M, Pitcairn C, Tsutsumi K, Fredriksen K, et al. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron. 2019;104:869-884.e11 pubmed publisher
Schaser A, Osterberg V, Dent S, Stackhouse T, Wakeham C, Boutros S, et al. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019;9:10919 pubmed publisher
Kim S, Kwon S, Kam T, Panicker N, Karuppagounder S, Lee S, et al. Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. Neuron. 2019;103:627-641.e7 pubmed publisher
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer N, Ma R, et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019;137:961-980 pubmed publisher
Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, et al. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol. 2019;137:939-960 pubmed publisher
Yamasaki T, Holmes B, Furman J, Dhavale D, Su B, Song E, et al. Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics. J Biol Chem. 2019;294:1045-1058 pubmed publisher
Ishiki A, Harada R, Kai H, Sato N, Totsune T, Tomita N, et al. Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy. Acta Neuropathol Commun. 2018;6:53 pubmed publisher
Ryan T, Bamm V, Stykel M, Coackley C, Humphries K, Jamieson Williams R, et al. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat Commun. 2018;9:817 pubmed publisher
Cai W, Feng D, Schwarzschild M, McLean P, Chen X. Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice. EBioMedicine. 2018;29:13-22 pubmed publisher
Groveman B, Orru C, Hughson A, Raymond L, Zanusso G, Ghetti B, et al. Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC. Acta Neuropathol Commun. 2018;6:7 pubmed publisher
Bottani E, Cerutti R, Harbour M, Ravaglia S, Doğan S, Giordano C, et al. TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III. Mol Cell. 2017;67:96-105.e4 pubmed publisher
Covell D, Robinson J, Akhtar R, Grossman M, Weintraub D, Bucklin H, et al. Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathol Appl Neurobiol. 2017;43:604-620 pubmed publisher
Doppler K, Jentschke H, Schulmeyer L, Vadász D, Janzen A, Luster M, et al. Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease. Acta Neuropathol. 2017;133:535-545 pubmed publisher
Lee J, Derkinderen P, Kordower J, Freeman R, Munoz D, Kremer T, et al. The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease. J Neuropathol Exp Neurol. 2017;76:2-15 pubmed publisher
Adamowicz D, Roy S, Salmon D, Galasko D, Hansen L, Masliah E, et al. Hippocampal ?-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017;37:1675-1684 pubmed publisher
Sampson T, Debelius J, Thron T, Janssen S, Shastri G, Ilhan Z, et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease. Cell. 2016;167:1469-1480.e12 pubmed publisher
Breid S, Bernis M, Babila J, Garza M, Wille H, TAMGUNEY G. Neuroinvasion of ?-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation. J Virol. 2016;90:9182-93 pubmed publisher
Doppler K, Volkmann J, Sommer C. Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?. Brain. 2016;139:e5 pubmed publisher
Volpicelli Daley L, Luk K, Lee V. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nat Protoc. 2014;9:2135-46 pubmed publisher
product information
Antigen :
alpha-Synuclein Phospho Ser129
Apps. Abbrev. :
IHC-P, ICC, IHC-F, WB, SB
Cat # :
825702
Clone :
P-syn/81A
Item :
Purified anti-α-Synuclein Phospho (Ser129)
Isotype :
Mouse IgG2a, κ
Other Names :
Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-A beta component of AD amyloid Parkinson disease (autosomal dominant, Lewy body) 4
Size :
25 μL
Price (USD) :
129 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
This monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 124 - 134 of α-synuclein, phosphorylated at Serine 129, and conjugated to KLH via a C-terminal Cysteine.
Application Notes :
This antibody is effective in immunohistochemistry (IHC-P). Additional reported applications (for the relevant formats) include: Western blotting, immunohistochemisty on frozen tissue sections (IHC-F), and immunocytochemistry.P-syn/81A is a mAb that is specific to alpha synuclein that has been phosphorylated on serine 129.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA