product summary
Loading...
company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified (azide-free) anti-α-Synuclein
catalog :
824301
quantity :
100 μL
price :
275 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Syn303
reactivity :
human
application :
western blot, immunohistochemistry - paraffin section
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 1a
Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1e
Mazzulli J, Zunke F, Tsunemi T, Toker N, Jeon S, Burbulla L, et al. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. J Neurosci. 2016;36:7693-706 pubmed publisher
Tao Y, Sun Y, Lv S, Xia W, Zhao K, Xu Q, et al. Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology. Nat Commun. 2022;13:4226 pubmed publisher
Macdonald J, Chen J, Masuda Suzukake M, Schweighauser M, Jaunmuktane Z, Warner T, et al. Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds. Acta Neuropathol Commun. 2021;9:189 pubmed publisher
Stojkovska I, Wani W, Zunke F, Belur N, Pavlenko E, Mwenda N, et al. Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking. Neuron. 2021;: pubmed publisher
Kahriman A, Bouley J, Smith T, Bosco D, Woerman A, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature. Acta Neuropathol Commun. 2021;9:118 pubmed publisher
Stojkovska I, Mazzulli J. Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue. STAR Protoc. 2021;2:100372 pubmed publisher
Pantazopoulou M, Brembati V, Kanellidi A, Bousset L, Melki R, Stefanis L. Distinct alpha-Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH-SY5Y cells. J Neurochem. 2021;156:880-896 pubmed publisher
Klingstedt T, Ghetti B, Holton J, Ling H, Nilsson K, Goedert M. Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy. Acta Neuropathol Commun. 2019;7:193 pubmed publisher
Abd Elhadi S, Grigoletto J, Poli M, Arosio P, Arkadir D, Sharon R. α-Synuclein in blood cells differentiates Parkinson's disease from healthy controls. Ann Clin Transl Neurol. 2019;6:2426-2436 pubmed publisher
Cuddy L, Wani W, Morella M, Pitcairn C, Tsutsumi K, Fredriksen K, et al. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron. 2019;104:869-884.e11 pubmed publisher
Nicot S, Verchère J, Belondrade M, Mayran C, Betemps D, Bougard D, et al. Seeded propagation of α-synuclein aggregation in mouse brain using protein misfolding cyclic amplification. FASEB J. 2019;33:12073-12086 pubmed publisher
Li X, Koudstaal W, Fletcher L, Costa M, Van Winsen M, Siregar B, et al. Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology. Acta Neuropathol. 2019;137:825-836 pubmed publisher
Sargent D, Verchère J, Lazizzera C, Gaillard D, Lakhdar L, Streichenberger N, et al. 'Prion-like' propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum. J Neurochem. 2017;143:126-135 pubmed publisher
Covell D, Robinson J, Akhtar R, Grossman M, Weintraub D, Bucklin H, et al. Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease. Neuropathol Appl Neurobiol. 2017;43:604-620 pubmed publisher
Tran H, Chung C, Iba M, Zhang B, Trojanowski J, Luk K, et al. ?-synuclein immunotherapy blocks uptake and templated propagation of misfolded ?-synuclein and neurodegeneration. Cell Rep. 2014;7:2054-65 pubmed publisher
Colla E, Jensen P, Pletnikova O, Troncoso J, Glabe C, Lee M. Accumulation of toxic ?-synuclein oligomer within endoplasmic reticulum occurs in ?-synucleinopathy in vivo. J Neurosci. 2012;32:3301-5 pubmed publisher
Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, et al. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci. 2010;30:3409-18 pubmed publisher
Luk K, Song C, O BRIEN P, Stieber A, Branch J, Brunden K, et al. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci U S A. 2009;106:20051-6 pubmed publisher
Soper J, Roy S, Stieber A, Lee E, Wilson R, Trojanowski J, et al. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:1093-103 pubmed publisher
Fan Y, Limprasert P, Murray I, Smith A, Lee V, Trojanowski J, et al. Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Hum Mol Genet. 2006;15:3002-11 pubmed
Wilson C, Murphy D, Giasson B, Zhang B, Trojanowski J, Lee V. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol. 2004;165:335-46 pubmed
Uryu K, Giasson B, Longhi L, Martinez D, Murray I, Conte V, et al. Age-dependent synuclein pathology following traumatic brain injury in mice. Exp Neurol. 2003;184:214-24 pubmed
Neumann M, Kahle P, Giasson B, Ozmen L, Borroni E, Spooren W, et al. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J Clin Invest. 2002;110:1429-39 pubmed
Giasson B, Duda J, Quinn S, Zhang B, Trojanowski J, Lee V. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 2002;34:521-33 pubmed
product information
Antigen :
alpha-Synuclein
Apps. Abbrev. :
IHC-P
Cat # :
824301
Clone :
Syn303
Item :
Purified (azide-free) anti-α-Synuclein
Isotype :
Mouse IgG1, κ
Other Names :
Alpha-synuclein, synuclein alpha-140, NACP, PARK1, PARK4, PD1
Size :
100 μL
Price (USD) :
275 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PUREAF
Application Notes :
This antibody is effective in formalin-fixed paraffin-embedded immunohistochemical staining (IHC-P).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA