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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-Myelin Basic Protein
catalog :
808403
quantity :
25 μL
price :
112 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SMI 99
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 82
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 5d
Sherafat A, Pfeiffer F, Reiss A, Wood W, Nishiyama A. Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor. Nat Commun. 2021;12:2265 pubmed publisher
  • western blot; mouse; fig 6d, s3d, s3e
Philips T, Mironova Y, Jouroukhin Y, Chew J, Vidensky S, Farah M, et al. MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration. Cell Rep. 2021;34:108610 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4e
  • immunocytochemistry; mouse; loading ...; fig 2e
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher
  • immunohistochemistry; human; 1:200; loading ...; fig 4, s2
Zhong X, Harris G, Smirnova L, Zufferey V, Sá R, Baldino Russo F, et al. Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model. Front Cell Neurosci. 2020;14:25 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 4a
Zhao Y, Sun X, Qi X. Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington's disease. Biochem Biophys Res Commun. 2018;507:319-323 pubmed publisher
Clawson E, Radecki D, Samanta J. Immunofluorescence assay for demyelination, remyelination, and proliferation in an acute cuprizone mouse model. STAR Protoc. 2023;4:102072 pubmed publisher
Xue W, Liu H, Xiao Y, Li B, Ren L, Li H, et al. Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing. iScience. 2023;26:105898 pubmed publisher
Montilla A, Zabala A, Er Lukowiak M, Rissiek B, Magnus T, Rodriguez Iglesias N, et al. Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis. Cell Death Dis. 2023;14:16 pubmed publisher
Yamanaka K, Nakamura K, Shibahara T, Takashima M, Takaki H, Hidaka M, et al. Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice. Glia. 2023;71:541-559 pubmed publisher
Weier A, Enders M, Kirchner P, Ekici A, Bigaud M, Kapitza C, et al. Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 2022;23: pubmed publisher
Ryu J, Jeizan P, Ahmed S, Ehsan S, Jose J, Regan S, et al. Post-Injury Buprenorphine Administration Is Associated with Long-Term Region-Specific Glial Alterations in Rats. Pharmaceutics. 2022;14: pubmed publisher
Matson K, Russ D, Kathe C, Hua I, Maric D, Ding Y, et al. Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons. Nat Commun. 2022;13:5628 pubmed publisher
Jablonska B, Adams K, Kratimenos P, Li Z, Strickland E, Haydar T, et al. Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia. Nat Commun. 2022;13:4771 pubmed publisher
Acheta J, Bhatia U, Haley J, Hong J, Rich K, Close R, et al. Piezo channels contribute to the regulation of myelination in Schwann cells. Glia. 2022;70:2276-2289 pubmed publisher
Wang N, Zhou L, Shao C, Wang X, Zhang N, Ma J, et al. Potassium channel Kir 4.1 regulates oligodendrocyte differentiation via intracellular pH regulation. Glia. 2022;70:2093-2107 pubmed publisher
x160 imi x107 G, Krsnik x, Knezovi x107 V, Kelovi x107 Z, Mathiasen M, Junakovi x107 A, et al. Prenatal development of the human entorhinal cortex. J Comp Neurol. 2022;530:2711-2748 pubmed publisher
Acheta J, Hong J, Jeanette H, Brar S, Yalamanchili A, Feltri M, et al. Cc2d1b Contributes to the Regulation of Developmental Myelination in the Central Nervous System. Front Mol Neurosci. 2022;15:881571 pubmed publisher
Palma A, Chara J, Montilla A, Otxoa de Amezaga A, Ru xed z Ja xe9 n F, Planas A, et al. Clemastine Induces an Impairment in Developmental Myelination. Front Cell Dev Biol. 2022;10:841548 pubmed publisher
Benardais K, Ornelas I, Fauveau M, Brown T, Finseth L, Panic R, et al. p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions. Brain Commun. 2022;4:fcac025 pubmed publisher
Radecki D, Samanta J. Isolation and culture of neural stem cells from adult mouse subventricular zone for genetic and pharmacological treatments with proliferation analysis. STAR Protoc. 2022;3:101153 pubmed publisher
St Pierre M, Rastogi N, Brown A, Parmar P, Lechner C, Fung C, et al. Intrauterine Growth Restriction Disrupts the Postnatal Critical Period of Synaptic Plasticity in the Mouse Dorsal Hippocampus in a Model of Hypertensive Disease of Pregnancy. Dev Neurosci. 2022;44:214-232 pubmed publisher
Zotter B, Dagan O, Brady J, Baloui H, Samanta J, Salzer J. Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture. J Neurosci. 2022;42:183-201 pubmed publisher
Ayanwuyi L, Tokarska N, McLean N, Johnston J, Verge V. Brief electrical nerve stimulation enhances intrinsic repair capacity of the focally demyelinated central nervous system. Neural Regen Res. 2022;17:1042-1050 pubmed publisher
Ahn J, Lee H, Lee K, Lim J, Hwang J, Kim C, et al. Effects of Lipopolysaccharide on Oligodendrocyte Differentiation at Different Developmental Stages: an In Vitro Study. J Korean Med Sci. 2021;36:e332 pubmed publisher
Chesnut M, Paschoud H, Repond C, Smirnova L, Hartung T, Zurich M, et al. Human IPSC-Derived Model to Study Myelin Disruption. Int J Mol Sci. 2021;22: pubmed publisher
Call C, Bergles D. Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination. Nat Commun. 2021;12:4767 pubmed publisher
Gobbo D, Scheller A, Kirchhoff F. From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research. Front Neurol. 2021;12:661408 pubmed publisher
Della Flora Nunes G, Wilson E, Marziali L, Hurley E, Silvestri N, He B, et al. Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nat Commun. 2021;12:3285 pubmed publisher
Roth L, Akay Espinoza C, Grinspan J, Jordan Sciutto K. HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response. Glia. 2021;69:2252-2271 pubmed publisher
Ryu J, Stone P, Lee S, Payne B, Gorse K, Lafrenaye A. Buprenorphine alters microglia and astrocytes acutely following diffuse traumatic brain injury. Sci Rep. 2021;11:8620 pubmed publisher
Huang S, Lu Q, Choi M, Zhang X, Kim J. Applying real-time monitoring of circadian oscillations in adult mouse brain slices to study communications between brain regions. STAR Protoc. 2021;2:100416 pubmed publisher
Teo W, Caprariello A, Morgan M, Luchicchi A, Schenk G, Joseph J, et al. Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Alam M, Zhao X, Liao Y, Mathur R, McCallum S, Mazurkiewicz J, et al. Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures. Eneuro. 2021;8: pubmed publisher
Zhang S, Wang Y, Zhu X, Song L, Zhan X, Ma E, et al. The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling. J Neurosci. 2021;41:1650-1664 pubmed publisher
Choi K, Lee J, Kang H. Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice. FASEB J. 2021;35:e21297 pubmed publisher
Zhang S, Wang Y, Xu J, Kim B, Deng W, Guo F. HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling. J Neurosci. 2021;41:251-268 pubmed publisher
Huang S, Choi M, Huang H, Wang X, Chang Y, Kim J. Demyelination Regulates the Circadian Transcription Factor BMAL1 to Signal Adult Neural Stem Cells to Initiate Oligodendrogenesis. Cell Rep. 2020;33:108394 pubmed publisher
Keogh C, Kim D, Pusceddu M, Knotts T, Rabasa G, Sladek J, et al. Myelin as a regulator of development of the microbiota-gut-brain axis. Brain Behav Immun. 2021;91:437-450 pubmed publisher
Allan K, Hu L, Scavuzzo M, Morton A, Gevorgyan A, Cohn E, et al. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Cell Stem Cell. 2021;28:257-272.e11 pubmed publisher
Ma Q, Matsunaga A, Ho B, Oksenberg J, Didonna A. Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020;17:297 pubmed publisher
Roth L, Zidane B, Festa L, Putatunda R, Romer M, Monnerie H, et al. Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response. Glia. 2021;69:362-376 pubmed publisher
Tian X, Zhu H, Du S, Zhang X, Lin F, Ji F, et al. Injectable PLGA-Coated Ropivacaine Produces A Long-Lasting Analgesic Effect on Incisional Pain and Neuropathic Pain. J Pain. 2021;22:180-195 pubmed publisher
Reed C, Frick L, Weaver A, Sidoli M, Schlant E, Feltri M, et al. Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury. J Neurosci. 2020;40:6165-6176 pubmed publisher
Elitt M, Barbar L, Shick H, Powers B, Maeno Hikichi Y, Madhavan M, et al. Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease. Nature. 2020;585:397-403 pubmed publisher
Lee S, Zhang Y, Park J, Kim B, Kim Y, Lee S, et al. Haploinsufficiency of Cyfip2 Causes Lithium-Responsive Prefrontal Dysfunction. Ann Neurol. 2020;: pubmed publisher
Orthmann Murphy J, Call C, Molina Castro G, Hsieh Y, Rasband M, Calabresi P, et al. Remyelination alters the pattern of myelin in the cerebral cortex. elife. 2020;9: pubmed publisher
Wang Q, Ding S, Li Y, Royall J, Feng D, Lesnar P, et al. The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas. Cell. 2020;181:936-953.e20 pubmed publisher
Williams G, Marmion D, Schonhoff A, Jurkuvenaite A, Won W, Standaert D, et al. T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease. Acta Neuropathol. 2020;139:855-874 pubmed publisher
Hanf K, Arndt J, Liu Y, Gong B, Rushe M, Sopko R, et al. Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site. MAbs. 2020;12:1713648 pubmed publisher
Zhang Y, Kang H, Han K. Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus. Anim Cells Syst (Seoul). 2019;23:380-383 pubmed publisher
Chew L, Ming X, McEllin B, Dupree J, Hong E, Catron M, et al. Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and Repair. Cell Rep. 2019;29:3173-3186.e7 pubmed publisher
Gail Canter R, Huang W, Choi H, Wang J, Ashley Watson L, Yao C, et al. 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Commun Biol. 2019;2:360 pubmed publisher
Sophie B, Jacob H, Jordan V, Yungki P, Laura F, Yannick P. YAP and TAZ Regulate Cc2d1b and Purβ in Schwann Cells. Front Mol Neurosci. 2019;12:177 pubmed publisher
Xin W, Mironova Y, Shen H, Marino R, Waisman A, Lamers W, et al. Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase. Cell Rep. 2019;27:2262-2271.e5 pubmed publisher
Ou Z, Ma Y, Sun Y, Zheng G, Wang S, Xing R, et al. A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Cell Rep. 2019;26:2984-2997.e4 pubmed publisher
Tammia M, Mi R, Sluch V, Zhu A, Chung T, Shinn D, et al. Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Heliyon. 2018;4:e00982 pubmed publisher
Rumajogee P, Altamentova S, Li L, Li J, Wang J, Kuurstra A, et al. Exogenous Neural Precursor Cell Transplantation Results in Structural and Functional Recovery in a Hypoxic-Ischemic Hemiplegic Mouse Model. Eneuro. 2018;5: pubmed publisher
de Rosa V, Secondo A, Pannaccione A, Ciccone R, Formisano L, Guida N, et al. D-Aspartate treatment attenuates myelin damage and stimulates myelin repair. EMBO Mol Med. 2019;11: pubmed publisher
Žunić Išasegi I, Rados M, Krsnik Z, Rados M, Benjak V, Kostovic I. Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall. Brain Struct Funct. 2018;223:3919-3943 pubmed publisher
Swartzlander D, Propson N, Roy E, Saito T, Saido T, Wang B, et al. Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease. JCI Insight. 2018;3: pubmed publisher
Yermakov L, Drouet D, GRIGGS R, Elased K, Susuki K. Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice. Front Cell Neurosci. 2018;12:146 pubmed publisher
Susuki K, Zollinger D, Chang K, Zhang C, Huang C, Tsai C, et al. Glial βII Spectrin Contributes to Paranode Formation and Maintenance. J Neurosci. 2018;38:6063-6075 pubmed publisher
Luo F, Zhang J, Burke K, Romito Digiacomo R, Miller R, Yang Y. Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory. Exp Neurol. 2018;306:92-104 pubmed publisher
Larson V, Mironova Y, Vanderpool K, Waisman A, Rash J, Agarwal A, et al. Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility. elife. 2018;7: pubmed publisher
González Fernández E, Jeong H, Fukaya M, Kim H, Khawaja R, Srivastava I, et al. PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling. elife. 2018;7: pubmed publisher
Barron T, Saifetiarova J, Bhat M, Kim J. Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus. Sci Rep. 2018;8:1022 pubmed publisher
Ziebell J, Ray Jones H, Lifshitz J. Nogo presence is inversely associated with shifts in cortical microglial morphology following experimental diffuse brain injury. Neuroscience. 2017;359:209-223 pubmed publisher
McLane L, Bourne J, Evangelou A, Khandker L, Macklin W, Wood T. Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination. J Neurosci. 2017;37:7534-7546 pubmed publisher
Bermejo P, Lopez M, Larraya I, Chamorro J, Cobo J, Ordonez S, et al. Innervation of the Human Cavum Conchae and Auditory Canal: Anatomical Basis for Transcutaneous Auricular Nerve Stimulation. Biomed Res Int. 2017;2017:7830919 pubmed publisher
Pamies D, Barreras P, Block K, Makri G, Kumar A, Wiersma D, et al. A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity. ALTEX. 2017;34:362-376 pubmed publisher
Jeffries M, Urbanek K, Torres L, Wendell S, Rubio M, Fyffe Maricich S. ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function. J Neurosci. 2016;36:9186-200 pubmed publisher
Shi Y, Shu J, Liang Z, Yuan S, Tang S. EXPRESS: Oligodendrocytes in HIV-associated pain pathogenesis. Mol Pain. 2016;12: pubmed publisher
Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, et al. Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016;19:995-8 pubmed publisher
Battefeld A, Klooster J, Kole M. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Nat Commun. 2016;7:11298 pubmed publisher
Luo F, Zhang J, Burke K, Miller R, Yang Y. The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination. J Neurosci. 2016;36:3024-37 pubmed publisher
Liu J, Dupree J, Gacias M, Frawley R, Sikder T, Naik P, et al. Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. J Neurosci. 2016;36:957-62 pubmed publisher
Hernandez M, Patzig J, Mayoral S, Costa K, Chan J, CASACCIA P. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. J Neurosci. 2016;36:806-13 pubmed publisher
Fyffe Maricich S, Karlo J, Landreth G, Miller R. The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. J Neurosci. 2011;31:843-50 pubmed publisher
Kiryu Seo S, Ohno N, Kidd G, Komuro H, Trapp B. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J Neurosci. 2010;30:6658-66 pubmed publisher
Del Valle L, Pina Oviedo S, Perez Liz G, Augelli B, Azizi S, Khalili K, et al. Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics. Cancer Biol Ther. 2010;9:286-94 pubmed publisher
Samanta J, Alden T, Gobeske K, Kan L, Kessler J. Noggin protects against ischemic brain injury in rodents. Stroke. 2010;41:357-62 pubmed publisher
Werner H, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, et al. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci. 2007;27:7717-30 pubmed
product information
Antigen :
Myelin Basic Protein
Apps. Abbrev. :
IHC-P, WB, ICC
Cat # :
808403
Clone :
SMI 99
Item :
Purified anti-Myelin Basic Protein
Isotype :
Mouse IgG2b, κ
Other Names :
MBP, Golli-MBP, myelin A1 protein, myelin membrane encephalitogenic protein
Size :
25 μL
Price (USD) :
112 USD
Reactivity :
Human, Mouse, Rat
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Application Notes :
This antibody reacts with the sequence Ala-Ser-Asp-Tyr-Lys-Ser in position 131-136 of the classic human myelin basic protein. The antibody detects myelin basic protein from most mammalian species. This antibody detects developing and adult myelin, developing oligodedrocytes and distinguishes oligodendrocytes from astrocytes, microglia, neurons, and other cells in brain sections. The combination of this antibody with clone SMI-91 and/or SMI-94 is useful for immunocytochemical studies on the progression of normal and pathologic myelination.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA