Purified (azide-free) anti-α-Synuclein, 103-108 | BioLegend 807802 product information

product summary

company name :

BioLegend

other brands :

Babco, Signet, Sternberger Monoclonals, Senetek, Covance

product type :

antibody

product name :

Purified (azide-free) anti-α-Synuclein, 103-108

catalog :

807802

quantity :

500 μL

price :

1036 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B12/Synuclein

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

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citations: 14

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; rat; 1:1000; loading ...; fig 1a western blot; rat; 1:1000; loading ...; fig 2c	Dimant H, Zhu L, Kibuuka L, Fan Z, Hyman B, McLean P. Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics. PLoS ONE. 2014;9:e92098 pubmed publisher
	Scheiblich H, Dansokho C, Mercan D, Schmidt S, Bousset L, Wischhof L, et al. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell. 2021;184:5089-5106.e21 pubmed publisher
	Zhao J, Lu W, Ren Y, Fu Y, Martens Y, Shue F, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathol. 2021;142:807-825 pubmed publisher
	Tanudjojo B, Shaikh S, Fenyi A, Bousset L, Agarwal D, Marsh J, et al. Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons. Nat Commun. 2021;12:3817 pubmed publisher
	Butkovich L, Houser M, Chalermpalanupap T, Porter Stransky K, Iannitelli A, Boles J, et al. Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease. J Neurosci. 2020;40:7559-7576 pubmed publisher
	Van der Perren A, Gelders G, Fenyi A, Bousset L, Brito F, Peelaerts W, et al. The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies. Acta Neuropathol. 2020;139:977-1000 pubmed publisher
	Zhao N, Attrebi O, Ren Y, Qiao W, Sonustun B, Martens Y, et al. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Sci Transl Med. 2020;12: pubmed publisher
	Kiechle M, von Einem B, Höfs L, Voehringer P, Grozdanov V, Markx D, et al. In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species. Cell Rep. 2019;29:2862-2874.e9 pubmed publisher
	Cuddy L, Wani W, Morella M, Pitcairn C, Tsutsumi K, Fredriksen K, et al. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron. 2019;104:869-884.e11 pubmed publisher
	Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, et al. Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay. Front Neurosci. 2019;13:889 pubmed publisher
	Schaser A, Osterberg V, Dent S, Stackhouse T, Wakeham C, Boutros S, et al. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019;9:10919 pubmed publisher
	Heras Garvín A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, et al. Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy. Mov Disord. 2019;34:255-263 pubmed publisher
	Jiang P, Gan M, Yen S, McLean P, Dickson D. Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates. Sci Rep. 2017;7:7690 pubmed publisher
	Phan J, Stokholm K, Zareba Paslawska J, Jakobsen S, Vang K, Gjedde A, et al. Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease. Sci Rep. 2017;7:6363 pubmed publisher

product information

Antigen :

alpha-Synuclein 103-108

Apps. Abbrev. :

IHC-P, ELISA, WB

Cat # :

807802

Clone :

4B12/Synuclein

Item :

Purified (azide-free) anti-α-Synuclein, 103-108

Isotype :

Mouse IgG1, κ

Other Names :

NACP, PARK1, PARK4, PD1, Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-A beta component of AD amyloid Parkinson disease

Size :

500 μL

Price (USD) :

1036 USD

Reactivity :

Human

Clonality :

Monoclonal

Host :

Mouse

Conjugate/Tag/Label :

PUREAF

Immunogen :

This antibody was developed using a purified, E. coli produced human α-synuclein.

Application Notes :

This antibody reacts with human a-synuclein. It does not react with mouse or rat a-synuclein. The epitope lies within amino acids 103-108 of a-synuclein.Additional reported applications (for the relevant formats) include: ELISA^2, Western blotting^1,2,3,4,6,8, and immunoprecipitation^4.;

more info or order :

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