product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Anti-β-Amyloid, 1-16
catalog :
803015
quantity :
200 μL
price :
1054 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6.00E+10
reactivity :
hamsters, human, mouse, rat, fruit fly , rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other
more info or order :
citations: 154
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1a
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 6c
Zhao P, Xu Y, Jiang L, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener. 2022;17:44 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4b
Marengo L, Armbrust F, Schoenherr C, Storck S, Schmitt U, Zampar S, et al. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Cell Mol Life Sci. 2022;79:168 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4e
Villanueva E, Tresse E, Liu Y, Duarte J, Jimenez Duran G, Ejlerskov P, et al. Neuronal TNFα, Not α-Syn, Underlies PDD-Like Disease Progression in IFNβ-KO Mice. Ann Neurol. 2021;90:789-807 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 1a
Zhang J, Wu N, Wang S, Yao Z, Xiao F, Lu J, et al. Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease. Aging Cell. 2021;20:e13380 pubmed publisher
  • ELISA; mouse
Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher
  • immunohistochemistry; mouse; fig s3b
Son G, Yoo S, Kang S, Rasheed A, Jung D, Park H, et al. Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice. Alzheimers Res Ther. 2021;13:4 pubmed publisher
  • immunohistochemistry; human; 1:1000; loading ...; fig 1a
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2500; loading ...; fig 4a
Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
  • western blot; human; loading ...; fig 3a
Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Mol Psychiatry. 2018;: pubmed publisher
  • western blot; human; fig 2a
Benvegnù S, Wahle T, Dotti C. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget. 2017;8:89439-89450 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 4a
Koistinen N, Edlund A, Menon P, Ivanova E, Bacanu S, Iverfeldt K. Nuclear localization of amyloid-? precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis. PLoS ONE. 2017;12:e0173888 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Croft C, Wade M, Kurbatskaya K, Mastrandreas P, Hughes M, Phillips E, et al. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis. 2017;8:e2671 pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig 4b
Gardenal E, Chiarini A, Armato U, Dal Pra I, Verkhratsky A, Rodriguez J. Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease. Front Neurosci. 2017;11:81 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig s2a
Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, et al. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease. Stem Cell Reports. 2017;8:84-94 pubmed publisher
  • immunohistochemistry; human; 1:2000; loading ...; tbl 1
Kordower J, Goetz C, Chu Y, Halliday G, Nicholson D, Musial T, et al. Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient. Ann Neurol. 2017;81:46-57 pubmed publisher
  • western blot; mouse; 1:1000; loading ...
Zhang H, Sun S, Wu L, Pchitskaya E, Zakharova O, Fon Tacer K, et al. Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment. J Neurosci. 2016;36:11837-11850 pubmed
  • western blot; human; loading ...; fig 3b
Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed publisher
  • western blot; mouse; fig 4
Xu J, De Winter F, Farrokhi C, Rockenstein E, Mante M, Adame A, et al. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep. 2016;6:31692 pubmed publisher
  • western blot; human; loading ...; fig 1b
Manocha G, Floden A, Rausch K, Kulas J, McGregor B, Rojanathammanee L, et al. APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease. J Neurosci. 2016;36:8471-86 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 4
Li T, Braunstein K, Zhang J, Lau A, Sibener L, Deeble C, et al. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016;7:12082 pubmed publisher
  • western blot; human; 1:2000; fig 2
Marzesco A, Flötenmeyer M, Bühler A, Obermüller U, Staufenbiel M, Jucker M, et al. Highly potent intracellular membrane-associated A? seeds. Sci Rep. 2016;6:28125 pubmed publisher
  • western blot; mouse; fig s1
Chan E, Shetty M, Sajikumar S, Chen C, Soong T, Wong B. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Sci Rep. 2016;6:26119 pubmed publisher
  • western blot; human; fig 2
Kurbatskaya K, Phillips E, Croft C, Dentoni G, Hughes M, Wade M, et al. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun. 2016;4:34 pubmed publisher
  • western blot; fruit fly ; fig 1
Ando K, Maruko Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima K. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity. PLoS Genet. 2016;12:e1005917 pubmed publisher
  • immunoprecipitation; human; fig 4
Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 4
  • western blot; mouse; 1:1000; fig 4
Peng Y, Kim M, Hullinger R, O Riordan K, Burger C, Pehar M, et al. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain. 2016;139:937-52 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
  • western blot; human; 1:1000; tbl 1
Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
  • western blot; hamsters; fig 7
Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  • western blot; fruit fly ; 1:2000; fig 2O
Lee S, Bang S, Hong Y, Lee J, Jeong H, Park S, et al. The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease. Dis Model Mech. 2016;9:295-306 pubmed publisher
  • immunohistochemistry; mouse; fig 5
Wang J, Lu R, Yang J, Li H, He Z, Jing N, et al. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun. 2015;6:8876 pubmed publisher
  • western blot; mouse; 1:1500; fig 3
  • western blot; human; 1:1500; fig 3
Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed publisher
  • western blot; mouse; 1:2000; fig 5e
Ostapchenko V, Chen M, Guzman M, Xie Y, Lavine N, Fan J, et al. The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J Neurosci. 2015;35:15157-69 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 1
Cherry J, Olschowka J, O Banion M. Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation. J Neuroinflammation. 2015;12:203 pubmed publisher
  • ELISA; human; 2 ug/ml; fig 6
Miners J, Palmer J, Love S. Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease. Brain Pathol. 2016;26:533-41 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 9a
Gabbita S, Johnson M, Kobritz N, Eslami P, Poteshkina A, Varadarajan S, et al. Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model. PLoS ONE. 2015;10:e0137305 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Kokiko Cochran O, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, et al. Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Neurotrauma. 2016;33:625-40 pubmed publisher
  • immunohistochemistry; human; tbl 1
Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher
  • western blot; mouse; fig 4
Lutzenberger M, Burwinkel M, Riemer C, Bode V, Baier M. Ablation of CCAAT/Enhancer-Binding Protein Delta (C/EBPD): Increased Plaque Burden in a Murine Alzheimer's Disease Model. PLoS ONE. 2015;10:e0134228 pubmed publisher
  • western blot; fruit fly
Nevzglyadova O, Mikhailova E, Amen T, Zenin V, Artemov A, Kostyleva E, et al. Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster. Amyloid. 2015;22:100-11 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200
Wang D, Kinoshita Y, Kinoshita C, Uo T, Sopher B, Cudaback E, et al. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015;138:2005-19 pubmed publisher
  • other; human; 1:100; loading ...; fig 2a
Cuddy L, Seah C, Pasternak S, Rylett R. Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein. J Neurochem. 2015;134:769-82 pubmed publisher
  • western blot; human
Wang H, Sang N, Zhang C, Raghupathi R, Tanzi R, SAUNDERS A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015;54:2806-16 pubmed publisher
  • immunoprecipitation; human
Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Yetman M, Lillehaug S, Bjaalie J, Leergaard T, Jankowsky J. Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex. Brain Struct Funct. 2016;221:2231-49 pubmed publisher
  • western blot; rat
PajÄ…k B, Kania E, Orzechowski A. Nucleofection of rat pheochromocytoma PC-12 cells with human mutated beta-amyloid precursor protein gene (APP-sw) leads to reduced viability, autophagy-like process, and increased expression and secretion of beta amyloid. Biomed Res Int. 2015;2015:746092 pubmed publisher
  • western blot; mouse; 1:2000
Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed publisher
  • western blot; rat; 1:500
Jay T, Miller C, Cheng P, Graham L, Bemiller S, Broihier M, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015;212:287-95 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:600
Wu Z, Yang B, Liu C, Liang G, Eckenhoff M, Liu W, et al. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer Dis Assoc Disord. 2015;29:184-191 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300
  • ELISA; human; 1:1000
Ashby E, Miners J, Kumar S, Walter J, Love S, Kehoe P. Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia. Neuropathol Appl Neurobiol. 2015;41:428-44 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Hohsfield L, Daschil N, Orädd G, Strömberg I, Humpel C. Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models. Mol Cell Neurosci. 2014;63:83-95 pubmed
  • western blot; human; 1:1000
Vingtdeux V, Tanis J, Chandakkar P, Zhao H, Dreses Werringloer U, Campagne F, et al. Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels. PLoS ONE. 2014;9:e112484 pubmed publisher
  • immunocytochemistry; mouse; 1:1000
  • western blot; mouse; 1:1000
Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed publisher
  • western blot; rhesus macaque; 1:1000
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher
  • immunocytochemistry; human
  • ELISA; human
  • western blot; human
Maloney J, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, et al. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. J Biol Chem. 2014;289:30990-1000 pubmed publisher
  • immunocytochemistry; mouse
Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed publisher
  • ELISA; mouse
Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, et al. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. J Biol Chem. 2014;289:27080-9 pubmed publisher
  • immunocytochemistry; human; 1:50
Kohler C, Dinekov M, Götz J. Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and A? amyloidosis. Neurobiol Dis. 2014;71:169-79 pubmed publisher
  • western blot; rat; 1:2000
  • western blot; mouse; 1:2000
Zeldich E, Chen C, Colvin T, Bove Fenderson E, Liang J, Tucker Zhou T, et al. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014;289:24700-15 pubmed publisher
  • western blot; human; 1:5000
Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher
  • western blot; mouse; 1:2500
Fowler S, Chiang A, Savjani R, Larson M, Sherman M, Schuler D, et al. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014;34:7871-85 pubmed publisher
  • western blot; mouse; 1:500
Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher
  • immunohistochemistry; human; 1 ug/ml
Xiong Z, Thangavel R, Kempuraj D, Yang E, Zaheer S, Zaheer A. Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain. J Alzheimers Dis. 2014;40:297-308 pubmed publisher
  • western blot; human; 1:1000
Bana L, Minniti S, Salvati E, Sesana S, Zambelli V, Cagnotto A, et al. Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A? aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease. Nanomedicine. 2014;10:1583-90 pubmed publisher
  • immunohistochemistry - free floating section; mouse
  • western blot; mouse
Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1500
ElAli A, Theriault P, Prefontaine P, Rivest S. Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation. Acta Neuropathol Commun. 2013;1:75 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:2000
Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, et al. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014;39:191-210 pubmed publisher
  • immunoprecipitation; mouse
Bhaskar K, Maphis N, Xu G, Varvel N, Kokiko Cochran O, Weick J, et al. Microglial derived tumor necrosis factor-? drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273-85 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Devi L, Ohno M. Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry. 2013;3:e284 pubmed publisher
  • immunohistochemistry; human
Jackson K, Barisone G, Diaz E, Jin L, DeCarli C, Despa F. Amylin deposition in the brain: A second amyloid in Alzheimer disease?. Ann Neurol. 2013;74:517-26 pubmed publisher
  • western blot; human
Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed publisher
  • western blot; human
Beyer A, von Einem B, Schwanzar D, Keller I, Hellrung A, Thal D, et al. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-? precursor protein. Neurobiol Aging. 2012;33:732-43 pubmed publisher
Na D, Zhang J, Beaulac H, Piekna Przybylska D, Nicklas P, Kiernan A, et al. Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis. Front Neurosci. 2023;17:1106570 pubmed publisher
Lin W, Li Z, Liang G, Zhou R, Zheng X, Tao R, et al. TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB/TFE3 activation. J Neuroinflammation. 2023;20:21 pubmed publisher
Yao S, Wang J, Xu Z, Meng Y, Xue Y, Yang F, et al. A peptide rich in glycine-serine-alanine repeats ameliorates Alzheimer-type neurodegeneration. Br J Pharmacol. 2023;180:1878-1896 pubmed publisher
Bathini P, Dupanloup I, Zenaro E, Terrabuio E, Fischer A, Ballabani E, et al. Systemic Inflammation Causes Microglial Dysfunction With a Vascular AD phenotype. Brain Behav Immun Health. 2023;28:100568 pubmed publisher
Jin J, Xu Z, Zhang L, Zhang C, Zhao X, Mao Y, et al. Gut-derived β-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis. Gut Microbes. 2023;15:2167172 pubmed publisher
Reddy T, Iguban M, Melkonyan L, Shergill J, Liang C, Mukherjee J. Development of [124/125I]IAZA as a New Proteinopathy Imaging Agent for Alzheimer's Disease. Molecules. 2023;28: pubmed publisher
Hu Y, Cao K, Wang F, Wu W, Mai W, Qiu L, et al. Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity. Nat Metab. 2022;4:1756-1774 pubmed publisher
Li S, Yan G, Tan Y, Xue L, Wang T, Zhao H, et al. Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1-42. Neural Plast. 2022;2022:3995227 pubmed publisher
Lucero E, Freund R, Smith A, Johnson N, Dooling B, Sullivan E, et al. Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction. iScience. 2022;25:105288 pubmed publisher
Shang Y, Sun X, Chen X, Wang Q, Wang E, Miller E, et al. A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease. Acta Neuropathol. 2022;144:911-938 pubmed publisher
Bishay J, Beckett T, Lai A, Hill M, McMahon D, McLaurin J. Venular amyloid accumulation in transgenic Fischer 344 Alzheimer's disease rats. Sci Rep. 2022;12:15287 pubmed publisher
Qiu Y, Sha L, Zhang X, Li G, Zhu W, Xu Q. Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk. Front Aging Neurosci. 2022;14:896522 pubmed publisher
Kumar S, Orlov E, Gowda P, Bose C, Swerdlow R, Lahiri D, et al. Synaptosome microRNAs regulate synapse functions in Alzheimer's disease. NPJ Genom Med. 2022;7:47 pubmed publisher
Nguyen G, Liang C, Mukherjee J. [124I]IBETA: A New Aβ Plaque Positron Emission Tomography Imaging Agent for Alzheimer's Disease. Molecules. 2022;27: pubmed publisher
Lai R, Hsu C, Yu B, Lo Y, Hsu Y, Chen M, et al. Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies. Aging Cell. 2022;21:e13670 pubmed publisher
Cai C, Wang L, Li S, Lou S, Luo J, Fu D, et al. Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation. J Neurosci. 2022;42:6090-6107 pubmed publisher
Janu xe1 rio Y, Eden J, de Oliveira L, De Pace R, Tavares L, da Silva Janu xe1 rio M, et al. Clathrin adaptor AP-1-mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments. J Biol Chem. 2022;298:102172 pubmed publisher
Peng D, Wang Y, Xiao Y, Peng M, Mai W, Hu B, et al. Extracellular vesicles derived from astrocyte-treated with haFGF14-154 attenuate Alzheimer phenotype in AD mice. Theranostics. 2022;12:3862-3881 pubmed publisher
Lin H, Gao Y, Zhang C, Ma B, Wu M, Cui X, et al. Autophagy Regulation Influences β-Amyloid Toxicity in Transgenic Caenorhabditis elegans. Front Aging Neurosci. 2022;14:885145 pubmed publisher
Huang S, Liao X, Wu J, Zhang X, Li Y, Xiang D, et al. The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid-β by microglia. FEBS Lett. 2022;596:1059-1071 pubmed publisher
Ren X, Yao L, Wang Y, Mei L, Xiong W. Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology. J Neuroinflammation. 2022;19:61 pubmed publisher
Shen Q, Wu X, Zhang Z, Zhang D, Yang S, Xing D. Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model. Aging Cell. 2022;21:e13573 pubmed publisher
Zhang Y, Chen H, Long X, Xu T. Three-dimensional-engineered bioprinted in vitro human neural stem cell self-assembling culture model constructs of Alzheimer's disease. Bioact Mater. 2022;11:192-205 pubmed publisher
Tang T, Jia J, Garbarino E, Chen L, Ma J, Li P, et al. Human Herpesvirus 6A U4 Inhibits Proteasomal Degradation of the Amyloid Precursor Protein. J Virol. 2022;96:e0168821 pubmed publisher
Chen S, He C, Shen Y, Zeng G, Tian D, Cheng Y, et al. Polysaccharide Krestin Prevents Alzheimer's Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing. Neurosci Bull. 2022;38:290-302 pubmed publisher
. Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts. Mol Imaging Biol. 2021;23:991-1738 pubmed publisher
Soto Mercado V, Mendivil Perez M, Velez Pardo C, Jimenez Del Rio M. (-)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer's Disease PSEN1 E280A. Biomolecules. 2021;11: pubmed publisher
Actor Engel H, Schwartz S, Crosby K, Sinnen B, Prikhodko O, Ramsay H, et al. Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits. Eneuro. 2021;8: pubmed publisher
Lai R, Hsu Y, Shie F, Huang C, Chen M, Juang J. Non-genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer's disease. Aging Cell. 2021;20:e13509 pubmed publisher
Willuweit A, Sch xf6 neck M, Schemmert S, Lohmann P, Bremen S, Honold D, et al. Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography. Front Neurosci. 2021;15:699926 pubmed publisher
Cone A, Yuan X, Sun L, Duke L, Vreones M, Carrier A, et al. Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model. Theranostics. 2021;11:8129-8142 pubmed publisher
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product information
Antigen :
beta-Amyloid 1-16
Apps. Abbrev. :
WB, Direct ELISA, IHC-P, IHC-F, EM
Cat # :
803015
Clone :
6.00E+10
Item :
Anti-β-Amyloid, 1-16
Isotype :
Mouse IgG1, κ
Other Names :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Size :
200 μL
Price (USD) :
1054 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
ASCITES
Application Notes :
This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS).This antibody clone has been reported for use in immunohistochemistry of free-floating sections^2,13.;
more info or order :
company information
BioLegend
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customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA