Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher

Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher

Moelgg K, Jummun F, Humpel C. Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons. Biomolecules. 2021;11: pubmed publisher

Arber C, Lovejoy C, Harris L, Willumsen N, Alatza A, Casey J, et al. Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis. Cell Rep. 2021;34:108615 pubmed publisher

Quartey M, Nyarko J, Maley J, Barnes J, Bolanos M, Heistad R, et al. The Aβ(1-38) peptide is a negative regulator of the Aβ(1-42) peptide implicated in Alzheimer disease progression. Sci Rep. 2021;11:431 pubmed publisher

Su Q, Li T, He P, Lu X, Yu Q, Gao Q, et al. Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice. Alzheimers Res Ther. 2021;13:7 pubmed publisher

Dai Y, Han G, Xu S, Yuan Y, Zhao C, Ma T. Echinacoside Suppresses Amyloidogenesis and Modulates F-actin Remodeling by Targeting the ER Stress Sensor PERK in a Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2020;8:593659 pubmed publisher

Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher

Shen Y, Hua L, Yeh C, Shen L, Ying M, Zhang Z, et al. Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease. Theranostics. 2020;10:11794-11819 pubmed publisher

Benthem S, Skelin I, Moseley S, Stimmell A, Dixon J, Melilli A, et al. Impaired Hippocampal-Cortical Interactions during Sleep in a Mouse Model of Alzheimer's Disease. Curr Biol. 2020;30:2588-2601.e5 pubmed publisher

Soto Mercado V, Mendivil Perez M, Velez Pardo C, Lopera F, Jimenez Del Rio M. Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications. PLoS ONE. 2020;15:e0221669 pubmed publisher

Ren Z, Dong Z, Xie P, Lv J, Hu Y, Guan Z, et al. PNU282987 inhibits amyloid‑β aggregation by upregulating astrocytic endogenous αB‑crystallin and HSP‑70 via regulation of the α7AChR, PI3K/Akt/HSF‑1 signaling axis. Mol Med Rep. 2020;22:201-208 pubmed publisher

Porter K, Sarkar S, Dakhlallah D, Vannoy M, Quintana D, Simpkins J. Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner. Front Aging Neurosci. 2020;12:92 pubmed publisher

Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, et al. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun. 2020;11:507 pubmed publisher

Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. J Neurosci. 2020;40:1956-1974 pubmed publisher

Arber C, Villegas Llerena C, Toombs J, Pocock J, Ryan N, Fox N, et al. Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout. Brain Commun. 2019;1:fcz024 pubmed publisher

Song J, Malampati S, Zeng Y, Durairajan S, Yang C, Tong B, et al. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2019;:e13069 pubmed publisher

Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher

Lana E, Gellerbring A, Jung S, Nordberg A, Unger Lithner C, Darreh Shori T. Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer's Disease Status and Risk Genotype. Front Mol Neurosci. 2019;12:176 pubmed publisher

Arber C, Toombs J, Lovejoy C, Ryan N, Paterson R, Willumsen N, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Mol Psychiatry. 2019;: pubmed publisher

Li N, Li Y, Li L, Zhu K, Zheng Y, Wang X. Glutamate receptor delocalization in postsynaptic membrane and reduced hippocampal synaptic plasticity in the early stage of Alzheimer's disease. Neural Regen Res. 2019;14:1037-1045 pubmed publisher

Cheng W, Martens K, Bashir A, Cheung H, Stukas S, Gibbs E, et al. CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice. Alzheimers Res Ther. 2019;11:6 pubmed publisher

Boeddrich A, Babila J, Wiglenda T, Diez L, Jacob M, Nietfeld W, et al. The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chem Biol. 2019;26:109-120.e7 pubmed publisher

Seino S, Kimoto T, Yoshida H, Tanji K, Matsumiya T, Hayakari R, et al. Gnetin C, a resveratrol dimer, reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ42-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells. Biomed Res. 2018;39:105-115 pubmed publisher

Fu W, Dai Y, Ma T, Wei J, Chen H, Xu S. Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 mice. Exp Ther Med. 2018;15:4005-4013 pubmed publisher

Lee C, Daggett A, Gu X, Jiang L, Langfelder P, Li X, et al. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018;97:1032-1048.e5 pubmed publisher

Casali B, Reed Geaghan E, Landreth G. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease. J Neuroinflammation. 2018;15:43 pubmed publisher

Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed publisher

Robert J, Button E, Yuen B, Gilmour M, Kang K, Bahrabadi A, et al. Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels. elife. 2017;6: pubmed publisher

Jang J, Cho H, Park H, Rhim H, Kang S. ALS-linked mutant SOD1 proteins promote A? aggregates in ALS through direct interaction with A?. Biochem Biophys Res Commun. 2017;493:697-707 pubmed publisher

Zhang X, Wang W, Jiang L, Liu H, Zhang B, Lim N, et al. Downregulation of RBO-PI4KIIIα Facilitates Aβ42 Secretion and Ameliorates Neural Deficits in Aβ42-Expressing Drosophila. J Neurosci. 2017;37:4928-4941 pubmed publisher

Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun. 2017;5:26 pubmed publisher

Scholtzova H, Do E, Dhakal S, Sun Y, Liu S, Mehta P, et al. Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits. J Neurosci. 2017;37:936-959 pubmed publisher

Kordower J, Goetz C, Chu Y, Halliday G, Nicholson D, Musial T, et al. Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient. Ann Neurol. 2017;81:46-57 pubmed publisher

Zhang H, Sun S, Wu L, Pchitskaya E, Zakharova O, Fon Tacer K, et al. Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment. J Neurosci. 2016;36:11837-11850 pubmed

Beraldo F, Ostapchenko V, Caetano F, Guimarães A, Ferretti G, Daude N, et al. Regulation of Amyloid ? Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex. J Biol Chem. 2016;291:21945-21955 pubmed

Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016;6:31895 pubmed publisher

Li T, Braunstein K, Zhang J, Lau A, Sibener L, Deeble C, et al. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016;7:12082 pubmed publisher

Heiss J, Barrett J, Yu Z, Haas L, Kostylev M, Strittmatter S. Early Activation of Experience-Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease. Cereb Cortex. 2017;27:3660-3674 pubmed publisher

Chan E, Shetty M, Sajikumar S, Chen C, Soong T, Wong B. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Sci Rep. 2016;6:26119 pubmed publisher

Omata Y, Tharasegaran S, Lim Y, Yamasaki Y, Ishigaki Y, Tatsuno T, et al. Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception. Aging (Albany NY). 2016;8:427-39 pubmed

Klohs J, Deistung A, Ielacqua G, Seuwen A, Kindler D, Schweser F, et al. Quantitative assessment of microvasculopathy in arcA? mice with USPIO-enhanced gradient echo MRI. J Cereb Blood Flow Metab. 2016;36:1614-24 pubmed publisher

Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher

Gowert N, Donner L, Chatterjee M, Eisele Y, Towhid S, Münzer P, et al. Blood platelets in the progression of Alzheimer's disease. PLoS ONE. 2014;9:e90523 pubmed publisher

Zheng Y, Wang Q, Xiao B, Lu Q, Wang Y, Wang X. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and ?-amyloid deposition in Alzheimer's disease models. PLoS ONE. 2012;7:e39035 pubmed publisher

Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed publisher

Thakker D, Weatherspoon M, Harrison J, Keene T, Lane D, KAEMMERER W, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2009;106:4501-6 pubmed publisher

Oddo S, Caccamo A, Green K, Liang K, Tran L, Chen Y, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005;102:3046-51 pubmed

Herzig M, Winkler D, Burgermeister P, Pfeifer M, Kohler E, Schmidt S, et al. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004;7:954-60 pubmed