product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Biotin (azide-free) anti-β-Amyloid, 1-16
catalog :
803009
quantity :
1 mL
price :
2284 USD
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
6E10
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 36
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 6c
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1a
Zhao P, Xu Y, Jiang L, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener. 2022;17:44 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4b
Marengo L, Armbrust F, Schoenherr C, Storck S, Schmitt U, Zampar S, et al. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Cell Mol Life Sci. 2022;79:168 pubmed publisher
  • ELISA; mouse
Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2500; loading ...; fig 4a
Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
  • western blot; human; loading ...; fig 3a
Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Mol Psychiatry. 2018;: pubmed publisher
  • western blot; human; fig 2a
Benvegnù S, Wahle T, Dotti C. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget. 2017;8:89439-89450 pubmed publisher
  • western blot; human
Webster S, Van Eldik L, Watterson D, Bachstetter A. Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. J Neurosci. 2015;35:6554-69 pubmed publisher
  • western blot; mouse; 1:2500
Fowler S, Chiang A, Savjani R, Larson M, Sherman M, Schuler D, et al. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014;34:7871-85 pubmed publisher
Sompol P, Gollihue J, Kraner S, Artiushin I, Cloyd R, Chishti E, et al. Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology. Aging Cell. 2021;20:e13416 pubmed publisher
Chen J, Liu K, Hu B, Li R, Xin W, Chen H, et al. Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease. Neuron. 2021;109:2292-2307.e5 pubmed publisher
Metaxas A, Thygesen C, Briting S, Landau A, Darvesh S, Finsen B. Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients. Front Cell Neurosci. 2019;13:538 pubmed publisher
Duncan M, Farlow H, Tirumalaraju C, Yun D, Wang C, Howard J, et al. Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice. Alzheimers Dement (N Y). 2019;5:70-80 pubmed publisher
Grant M, Handoko M, Rozga M, Brinkmalm G, Portelius E, Blennow K, et al. Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments. PLoS ONE. 2019;14:e0212815 pubmed publisher
Busche M, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, et al. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nat Neurosci. 2019;22:57-64 pubmed publisher
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed publisher
Chernick D, Ortiz Valle S, Jeong A, Swaminathan S, Kandimalla K, Rebeck G, et al. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. J Neurochem. 2018;147:647-662 pubmed publisher
Osborne C, West E, Bate C. The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage. J Cell Sci. 2018;131: pubmed publisher
Chiang A, Fowler S, Reddy R, Pletnikova O, Troncoso J, Sherman M, et al. Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018;188:739-756 pubmed publisher
West E, Osborne C, Bate C. The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-?. J Cell Sci. 2017;130:3050-3059 pubmed publisher
Mateus A, Gordon L, Wayne G, Almqvist H, Axelsson H, Seashore Ludlow B, et al. Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery. Proc Natl Acad Sci U S A. 2017;114:E6231-E6239 pubmed publisher
Sompol P, Furman J, Pleiss M, Kraner S, Artiushin I, Batten S, et al. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in A?-Bearing Mice. J Neurosci. 2017;37:6132-6148 pubmed publisher
Zhou Z, Bachstetter A, Späni C, Roy S, Watterson D, Van Eldik L. Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes. J Neuroinflammation. 2017;14:75 pubmed publisher
Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun. 2017;5:26 pubmed publisher
Carter A, Letronne F, Fitz N, Mounier A, Wolfe C, Nam K, et al. Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice. PLoS ONE. 2017;12:e0172161 pubmed publisher
Sherman M, LaCroix M, Amar F, Larson M, Forster C, Aguzzi A, et al. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci. 2016;36:9647-58 pubmed publisher
Alfonso S, Callender J, Hooli B, Antal C, Mullin K, Sherman M, et al. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016;9:ra47 pubmed publisher
Omata Y, Tharasegaran S, Lim Y, Yamasaki Y, Ishigaki Y, Tatsuno T, et al. Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception. Aging (Albany NY). 2016;8:427-39 pubmed
Lathuilière A, Laversenne V, Astolfo A, Kopetzki E, Jacobsen H, Stampanoni M, et al. A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies. Brain. 2016;139:1587-604 pubmed publisher
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher
Gowert N, Donner L, Chatterjee M, Eisele Y, Towhid S, Münzer P, et al. Blood platelets in the progression of Alzheimer's disease. PLoS ONE. 2014;9:e90523 pubmed publisher
Larson M, Sherman M, Greimel S, Kuskowski M, Schneider J, Bennett D, et al. Soluble ?-synuclein is a novel modulator of Alzheimer's disease pathophysiology. J Neurosci. 2012;32:10253-66 pubmed publisher
Zheng Y, Wang Q, Xiao B, Lu Q, Wang Y, Wang X. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and ?-amyloid deposition in Alzheimer's disease models. PLoS ONE. 2012;7:e39035 pubmed publisher
Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed publisher
Thakker D, Weatherspoon M, Harrison J, Keene T, Lane D, KAEMMERER W, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2009;106:4501-6 pubmed publisher
Oddo S, Caccamo A, Green K, Liang K, Tran L, Chen Y, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005;102:3046-51 pubmed
Herzig M, Winkler D, Burgermeister P, Pfeifer M, Kohler E, Schmidt S, et al. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004;7:954-60 pubmed
product information
Antigen :
beta-Amyloid 1-16
Apps. Abbrev. :
IHC-P
Cat # :
803009
Clone :
6E10
Item :
Biotin (azide-free) anti-β-Amyloid, 1-16
Isotype :
Mouse IgG1, κ
Other Names :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Size :
1 mL
Price (USD) :
2284 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BIOTINAF
Application Notes :
This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). This antibody clone has been reported for use in immunohistochemistry of free-floating sections 2,13 .
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA