Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher

Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, et al. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model. Protein Cell. 2021;: pubmed publisher

Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher

Miguel J, Perez S, Malek Ahmadi M, Mufson E. Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease. Front Aging Neurosci. 2021;13:645334 pubmed publisher

Ikonomovic M, Buckley C, Abrahamson E, Kofler J, Mathis C, Klunk W, et al. Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer's disease. Acta Neuropathol. 2020;140:463-476 pubmed publisher

Kazuki Y, Gao F, Li Y, Moyer A, Devenney B, Hiramatsu K, et al. A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21. elife. 2020;9: pubmed publisher

Wander C, Tseng J, Song S, Al Housseiny H, Tart D, Ajit A, et al. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. 2020;23:101255 pubmed publisher

Rodriguez Ortiz C, Prieto G, Martini A, Forner S, Trujillo Estrada L, LaFerla F, et al. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13118 pubmed publisher

Moreno Rodríguez M, Perez S, Nadeem M, Malek Ahmadi M, Mufson E. Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease. J Neuroinflammation. 2020;17:58 pubmed publisher

Eede P, Obst J, Benke E, Yvon Durocher G, Richard B, Gimber N, et al. Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice. EMBO Rep. 2020;21:e48530 pubmed publisher

El Gaamouch F, Audrain M, Lin W, Beckmann N, Jiang C, Hariharan S, et al. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Mol Neurodegener. 2020;15:4 pubmed publisher

Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher

Pan R, Ma J, Kong X, Wang X, Li S, Qi X, et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance. Sci Adv. 2019;5:eaau6328 pubmed publisher

Sri S, Pegasiou C, Cave C, Hough K, Wood N, Gomez Nicola D, et al. Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2019;7:25 pubmed publisher

Rosenzweig N, Dvir Szternfeld R, Tsitsou Kampeli A, Keren Shaul H, Ben Yehuda H, Weill Raynal P, et al. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model. Nat Commun. 2019;10:465 pubmed publisher

Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher

Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Mol Psychiatry. 2018;: pubmed publisher

Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed publisher

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E, et al. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018;115:E1876-E1885 pubmed publisher

Mukadam A, Breusegem S, Seaman M. Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing. Cell Mol Life Sci. 2018;75:2613-2625 pubmed publisher

Cramer P, Gentzel R, Tanis K, Vardigan J, Wang Y, Connolly B, et al. Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease. Neurobiol Aging. 2018;64:92-106 pubmed publisher

Chiang A, Fowler S, Reddy R, Pletnikova O, Troncoso J, Sherman M, et al. Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018;188:739-756 pubmed publisher

Benvegnù S, Wahle T, Dotti C. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget. 2017;8:89439-89450 pubmed publisher

Edler M, Sherwood C, Meindl R, Hopkins W, Ely J, Erwin J, et al. Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease. Neurobiol Aging. 2017;59:107-120 pubmed publisher

Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher

Koistinen N, Edlund A, Menon P, Ivanova E, Bacanu S, Iverfeldt K. Nuclear localization of amyloid-? precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis. PLoS ONE. 2017;12:e0173888 pubmed publisher

Gardenal E, Chiarini A, Armato U, Dal Pra I, Verkhratsky A, Rodriguez J. Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease. Front Neurosci. 2017;11:81 pubmed publisher

Zheng T, Pu J, Chen Y, Mao Y, Guo Z, Pan H, et al. Plasma Exosomes Spread and Cluster Around ?-Amyloid Plaques in an Animal Model of Alzheimer's Disease. Front Aging Neurosci. 2017;9:12 pubmed publisher

Mellott T, Huleatt O, Shade B, Pender S, Liu Y, Slack B, et al. Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS ONE. 2017;12:e0170450 pubmed publisher

Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed publisher

Yang S, Lee D, Shin J, Lee S, Baek S, Kim J, et al. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO Mol Med. 2017;9:61-77 pubmed publisher

Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed publisher

Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed publisher

Xu J, De Winter F, Farrokhi C, Rockenstein E, Mante M, Adame A, et al. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep. 2016;6:31692 pubmed publisher

Marzesco A, Flötenmeyer M, Bühler A, Obermüller U, Staufenbiel M, Jucker M, et al. Highly potent intracellular membrane-associated A? seeds. Sci Rep. 2016;6:28125 pubmed publisher

Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, et al. Deacetylation of TFEB promotes fibrillar A? degradation by upregulating lysosomal biogenesis in microglia. Protein Cell. 2016;7:417-33 pubmed publisher

Ando K, Maruko Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima K. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity. PLoS Genet. 2016;12:e1005917 pubmed publisher

Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed publisher

Perez S, Sherwood C, Cranfield M, Erwin J, Mudakikwa A, Hof P, et al. Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol Aging. 2016;39:195-201 pubmed publisher

Peng Y, Kim M, Hullinger R, O Riordan K, Burger C, Pehar M, et al. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain. 2016;139:937-52 pubmed publisher

Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher

Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher

Lee S, Bang S, Hong Y, Lee J, Jeong H, Park S, et al. The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease. Dis Model Mech. 2016;9:295-306 pubmed publisher

Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed publisher

Ostapchenko V, Chen M, Guzman M, Xie Y, Lavine N, Fan J, et al. The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J Neurosci. 2015;35:15157-69 pubmed publisher

Sabogal Guáqueta A, Osorio E, Cardona Gómez G. Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice. Neuropharmacology. 2016;102:111-20 pubmed publisher

Cherry J, Olschowka J, O Banion M. Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation. J Neuroinflammation. 2015;12:203 pubmed publisher

Kumar R, Nordberg A, Darreh Shori T. Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs. Brain. 2016;139:174-92 pubmed publisher

Miners J, Palmer J, Love S. Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease. Brain Pathol. 2016;26:533-41 pubmed publisher

Kokiko Cochran O, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, et al. Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Neurotrauma. 2016;33:625-40 pubmed publisher

Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher

Nevzglyadova O, Mikhailova E, Amen T, Zenin V, Artemov A, Kostyleva E, et al. Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster. Amyloid. 2015;22:100-11 pubmed publisher

Cuddy L, Seah C, Pasternak S, Rylett R. Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein. J Neurochem. 2015;134:769-82 pubmed publisher

Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed publisher

Yetman M, Lillehaug S, Bjaalie J, Leergaard T, Jankowsky J. Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex. Brain Struct Funct. 2016;221:2231-49 pubmed publisher

Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed publisher

Jay T, Miller C, Cheng P, Graham L, Bemiller S, Broihier M, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015;212:287-95 pubmed publisher

Sabogal Guáqueta A, Muñoz Manco J, Ramírez Pineda J, Lamprea Rodriguez M, Osorio E, Cardona Gómez G. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. Neuropharmacology. 2015;93:134-45 pubmed publisher

Wu Z, Yang B, Liu C, Liang G, Eckenhoff M, Liu W, et al. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer Dis Assoc Disord. 2015;29:184-191 pubmed publisher

Kang E, Cho J. Effects of treadmill exercise on brain insulin signaling and β-amyloid in intracerebroventricular streptozotocin induced-memory impairment in rats. J Exerc Nutrition Biochem. 2014;18:89-96 pubmed publisher

Ashby E, Miners J, Kumar S, Walter J, Love S, Kehoe P. Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia. Neuropathol Appl Neurobiol. 2015;41:428-44 pubmed publisher

Vingtdeux V, Tanis J, Chandakkar P, Zhao H, Dreses Werringloer U, Campagne F, et al. Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels. PLoS ONE. 2014;9:e112484 pubmed publisher

Thomzig A, Wagenführ K, Daus M, Joncic M, Schulz Schaeffer W, Thanheiser M, et al. Decontamination of medical devices from pathological amyloid-?-, tau- and ?-synuclein aggregates. Acta Neuropathol Commun. 2014;2:151 pubmed publisher

Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed publisher

Maloney J, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, et al. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. J Biol Chem. 2014;289:30990-1000 pubmed publisher

Lue L, Schmitz C, Serrano G, Sue L, Beach T, Walker D. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices. Brain Pathol. 2015;25:469-80 pubmed publisher

Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed publisher

Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, et al. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. J Biol Chem. 2014;289:27080-9 pubmed publisher

Kohler C, Dinekov M, Götz J. Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and A? amyloidosis. Neurobiol Dis. 2014;71:169-79 pubmed publisher

Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger J, Zerbinatti C. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE. 2014;9:e103187 pubmed publisher

Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher

Fowler S, Chiang A, Savjani R, Larson M, Sherman M, Schuler D, et al. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014;34:7871-85 pubmed publisher

Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher

Xiong Z, Thangavel R, Kempuraj D, Yang E, Zaheer S, Zaheer A. Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain. J Alzheimers Dis. 2014;40:297-308 pubmed publisher

Bana L, Minniti S, Salvati E, Sesana S, Zambelli V, Cagnotto A, et al. Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A? aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease. Nanomedicine. 2014;10:1583-90 pubmed publisher

Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed publisher

El Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell. 2014;13:165-74 pubmed publisher

ElAli A, Theriault P, Prefontaine P, Rivest S. Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation. Acta Neuropathol Commun. 2013;1:75 pubmed publisher

Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, et al. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014;39:191-210 pubmed publisher

Washington P, Morffy N, Parsadanian M, Zapple D, Burns M. Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model. J Neurotrauma. 2014;31:125-34 pubmed publisher

Li W, Tang Y, Fan Z, Meng Y, Yang G, Luo J, et al. Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide. Mol Neurodegener. 2013;8:27 pubmed publisher

Kang E, Kwon I, Koo J, Kim E, Kim C, Lee J, et al. Treadmill exercise represses neuronal cell death and inflammation during A?-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis. 2013;18:1332-1347 pubmed publisher

Devi L, Ohno M. Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry. 2013;3:e284 pubmed publisher

Jackson K, Barisone G, Diaz E, Jin L, DeCarli C, Despa F. Amylin deposition in the brain: A second amyloid in Alzheimer disease?. Ann Neurol. 2013;74:517-26 pubmed publisher

Brana C, Frossard M, Pescini Gobert R, Martinier N, Boschert U, Seabrook T. Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions. Neuropathol Appl Neurobiol. 2014;40:564-78 pubmed publisher

Choi J, Kaur G, Mazzella M, Morales Corraliza J, Levy E, Mathews P. Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-? protein precursor transgenic mice. J Alzheimers Dis. 2013;34:691-700 pubmed publisher

Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed publisher

Beyer A, von Einem B, Schwanzar D, Keller I, Hellrung A, Thal D, et al. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-? precursor protein. Neurobiol Aging. 2012;33:732-43 pubmed publisher

Hao X, Li Z, Li W, Katz J, Michalek S, Barnum S, et al. Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice. Front Immunol. 2022;13:816640 pubmed publisher

Li L, Li J, Dai Y, Yang M, Liang S, Wang Z, et al. Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease Mice via Basal Forebrain-Hippocampus Cholinergic Neural Circuit. Front Aging Neurosci. 2021;13:770948 pubmed publisher

Hung C, Tuck E, Stubbs V, van der Lee S, Aalfs C, van Spaendonk R, et al. SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network. Cell Rep. 2021;35:109259 pubmed publisher

Doré K, Carrico Z, Alfonso S, Marino M, Koymans K, Kessels H, et al. PSD-95 protects synapses from β-amyloid. Cell Rep. 2021;35:109194 pubmed publisher

Hsu C, Chang C, Poopradubsil T, Lo A, William K, Lin K, et al. Antibody Watch: Text mining antibody specificity from the literature. PLoS Comput Biol. 2021;17:e1008967 pubmed publisher

Martin L, Bouvet P, Chounlamountri N, Watrin C, Besancon R, Pinatel D, et al. VEGF counteracts amyloid-β-induced synaptic dysfunction. Cell Rep. 2021;35:109121 pubmed publisher

Bourdenx M, Martín Segura A, Scrivo A, Rodriguez Navarro J, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696-2714.e25 pubmed publisher

Colombo A, Sadler R, Llovera G, Singh V, Roth S, Heindl S, et al. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. elife. 2021;10: pubmed publisher

La Barbera L, Vedele F, Nobili A, Krashia P, Spoleti E, Latagliata E, et al. Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease. Prog Neurobiol. 2021;202:102031 pubmed publisher

Guo X, Liu Y, Morgan D, Zhao L. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging Dis. 2020;11:1423-1443 pubmed publisher

Leal N, Dentoni G, Schreiner B, Naia L, Piras A, Graff C, et al. Amyloid Β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer's Disease-Related Models. Cells. 2020;9: pubmed publisher

Cho Y, Kwon O, Chung S. Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains. Molecules. 2020;25: pubmed publisher

Lin L, Petralia R, Lake R, Wang Y, Hoffman D. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197 pubmed publisher

Cen X, Chen Y, Xu X, Wu R, He F, Zhao Q, et al. Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model. Nat Commun. 2020;11:5731 pubmed publisher

Jeon S, Kim N, Ju Y, Gee M, Lee D, Lee J. Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2. Int J Mol Sci. 2020;21: pubmed publisher

Doustar J, Rentsendorj A, Torbati T, Regis G, Fuchs D, Sheyn J, et al. Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models. Aging Cell. 2020;:e13246 pubmed publisher

Montalbano M, McAllen S, Cascio F, Sengupta U, Garcia S, Bhatt N, et al. TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Neurobiol Dis. 2020;146:105130 pubmed publisher

Huang L, McClatchy D, Maher P, Liang Z, Diedrich J, Soriano Castell D, et al. Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death. Cell Death Dis. 2020;11:828 pubmed publisher

Farid M, Yang X, Kuboyama T, Tohda C. Trigonelline recovers memory function in Alzheimer's disease model mice: evidence of brain penetration and target molecule. Sci Rep. 2020;10:16424 pubmed publisher

Mo D, Li X, Raabe C, Rozhdestvensky T, Skryabin B, Brosius J. Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. Cells. 2020;9: pubmed publisher

Lee Y, Choi Y, Park E, Kwon S, Kim H, Lee J, et al. Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer's disease model. Sci Rep. 2020;10:16144 pubmed publisher

Yao J, Sun B, Institoris A, Zhan X, Guo W, Song Z, et al. Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation. Cell Rep. 2020;32:108169 pubmed publisher

Shippy D, Wilhelm C, Viharkumar P, Raife T, Ulland T. β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology. J Neuroinflammation. 2020;17:280 pubmed publisher

Li L, Li L, Zhang J, Huang S, Liu W, Wang Z, et al. Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer's Disease. Neural Plast. 2020;2020:8836173 pubmed publisher

von Saucken V, Jay T, Landreth G. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiol Dis. 2020;145:105072 pubmed publisher

Liu D, Zhao Y, Qi Y, Gao Y, Tu D, Wang Y, et al. Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice. J Neuroinflammation. 2020;17:258 pubmed publisher

Lackie R, Marques Lopes J, Ostapchenko V, Good S, Choy W, van Oosten Hawle P, et al. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:143 pubmed publisher

Pérez González R, Kim Y, Miller C, Pacheco Quinto J, Eckman E, Levy E. Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes. FASEB J. 2020;34:12922-12931 pubmed publisher

Chen W, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, et al. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. Cell. 2020;182:976-991.e19 pubmed publisher

Neddens J, Daurer M, Flunkert S, Beutl K, Loeffler T, Walker L, et al. Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models. PLoS ONE. 2020;15:e0235543 pubmed publisher

Shi Y, Zhang L, Gao X, Zhang J, Ben Abou M, Liang G, et al. Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice. J Alzheimers Dis. 2020;76:1375-1389 pubmed publisher

Ren J, Zhang S, Wang X, Guan Z, Qi X. Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells. Mol Med Rep. 2020;22:2063-2075 pubmed publisher

Socodato R, Portugal C, Canedo T, Rodrigues A, Almeida T, Henriques J, et al. Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell Rep. 2020;31:107796 pubmed publisher

Zhang H, Chen W, Tan Z, Zhang L, Dong Z, Cui W, et al. A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Aβ Clearance. J Neurosci. 2020;40:5347-5361 pubmed publisher

Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, et al. Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress. Oxid Med Cell Longev. 2020;2020:3050971 pubmed publisher

Maron R, Armony G, Tsoory M, Wilchek M, Frenkel D, Arnon R. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. Int J Mol Sci. 2020;21: pubmed publisher

Calvo Rodríguez M, Hou S, Snyder A, Kharitonova E, Russ A, Das S, et al. Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nat Commun. 2020;11:2146 pubmed publisher

Gee M, Son S, Jeon S, Do J, Kim N, Ju Y, et al. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimers Res Ther. 2020;12:45 pubmed publisher

Tambini M, D ADAMIO L. Knock-in rats with homozygous PSEN1L435F Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43. J Biol Chem. 2020;295:7442-7451 pubmed publisher

Brozzetti L, Sacchetto L, Cecchini M, Avesani A, Perra D, Bongianni M, et al. Neurodegeneration-Associated Proteins in Human Olfactory Neurons Collected by Nasal Brushing. Front Neurosci. 2020;14:145 pubmed publisher

An Y, Zhang H, Huang S, Pei G. PL201, a Reported Rhamnoside Against Alzheimer's Disease Pathology, Alleviates Neuroinflammation and Stimulates Nrf2 Signaling. Front Immunol. 2020;11:162 pubmed publisher

Li S, Hayden E, Garcia V, Fuchs D, Sheyn J, Daley D, et al. Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses. Front Immunol. 2020;11:49 pubmed publisher

Chen X, Ji B, Hao X, Li X, Eisele F, Nystrom T, et al. FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism. Nat Commun. 2020;11:867 pubmed publisher

Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed publisher

Tambini M, Norris K, D ADAMIO L. Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation. elife. 2020;9: pubmed publisher

Reed Geaghan E, Croxford A, Becher B, Landreth G. Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model. J Exp Med. 2020;217: pubmed publisher

Yan T, Liang J, Gao J, Wang L, Fujioka H, Zhu X, et al. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nat Commun. 2020;11:411 pubmed publisher

Bai B, Wang X, Li Y, Chen P, Yu K, Dey K, et al. Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression. Neuron. 2020;105:975-991.e7 pubmed publisher

Pi G, Gao D, Wu D, Wang Y, Lei H, Zeng W, et al. Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect. Nat Commun. 2020;11:183 pubmed publisher

Hu T, Zhou Y, Lu J, Xia P, Chen Y, Cao X, et al. A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer's-like pathology. Aging (Albany NY). 2020;12:481-501 pubmed publisher

Koronyo Hamaoui M, Sheyn J, Hayden E, Li S, Fuchs D, Regis G, et al. Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease. Brain. 2020;143:336-358 pubmed publisher

Michno W, Wehrli P, Meier S, Sehlin D, Syvänen S, Zetterberg H, et al. Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease. J Neurochem. 2020;152:602-616 pubmed publisher

Fiock K, Smith J, Crary J, Hefti M. β-amyloid and tau pathology in the aging feline brain. J Comp Neurol. 2020;528:108-113 pubmed publisher

Ren J, Wang X, Gao Y, Wang F, Guan Z, Qi X. The expression of the nicotinic acetylcholine receptor α3 subunit in the brains of patients with Alzheimer's disease and its effects on α- and γ-secretases and Notch signal transduction in SH-SY5Y cells. Int J Clin Exp Pathol. 2019;12:3644-3652 pubmed

Wang S, Jiang W, Ouyang T, Shen X, Wang F, Qu Y, et al. Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice. Sci Rep. 2019;9:19575 pubmed publisher

Medina C, Uselman T, Barto D, Chaves F, Jacobs R, Bearer E. Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain. Front Cell Neurosci. 2019;13:501 pubmed publisher

Lee H, Lee K, Chen C, Lee T. Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019;16:267 pubmed publisher

Beraldo F, Palmer D, Memar S, Wasserman D, Lee W, Liang S, et al. MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment. elife. 2019;8: pubmed publisher

Pires G, McElligott S, Drusinsky S, Halliday G, Potier M, Wisniewski T, et al. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathol Commun. 2019;7:195 pubmed publisher

Cox L, Schafer M, Sohn J, Vincentini J, Weiner H, Ginsberg S, et al. Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice. Sci Rep. 2019;9:17904 pubmed publisher

Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, et al. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls. elife. 2019;8: pubmed publisher

Ding Y, Zhao J, Zhang X, Wang S, Viola K, Chow F, et al. Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease. Front Neurol. 2019;10:1140 pubmed publisher

Kollmer M, Close W, Funk L, Rasmussen J, Bsoul A, Schierhorn A, et al. Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun. 2019;10:4760 pubmed publisher

Hansson O, Svensson M, Gustavsson A, Andersson E, Yang Y, Nagga K, et al. Midlife physical activity is associated with lower incidence of vascular dementia but not Alzheimer's disease. Alzheimers Res Ther. 2019;11:87 pubmed publisher

Griner S, Seidler P, Bowler J, Murray K, Yang T, Sahay S, et al. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. elife. 2019;8: pubmed publisher

van Husen L, Schedin Weiss S, Trung M, Kazmi M, Winblad B, Sakmar T, et al. Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products. J Alzheimers Dis. 2019;72:537-548 pubmed publisher

Zysk M, Clausen F, Aguilar X, Sehlin D, Syvänen S, Erlandsson A. Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2019;72:161-180 pubmed publisher

Bonds J, Shetti A, Bheri A, Chen Z, Disouky A, Tai L, et al. Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors. J Neurosci. 2019;39:8576-8583 pubmed publisher

Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019;29:787-803 pubmed publisher

Shmueli M, Hizkiahou N, Peled S, Gazit E, Segal D. Total proteome turbidity assay for tracking global protein aggregation in the natural cellular environment. J Biol Methods. 2017;4:e69 pubmed publisher

Esposito G, Mai L, Longeon A, Mangoni A, Durieu E, Meijer L, et al. A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens. Mar Drugs. 2019;17: pubmed publisher

SPANGENBERG E, Severson P, Hohsfield L, Crapser J, Zhang J, Burton E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019;10:3758 pubmed publisher

de Dios C, Bartolessis I, Roca Agujetas V, Barbero Camps E, Mari M, Morales A, et al. Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress. Redox Biol. 2019;26:101283 pubmed publisher

Imanikia S, Sheng M, Castro C, Griffin J, Taylor R. XBP-1 Remodels Lipid Metabolism to Extend Longevity. Cell Rep. 2019;28:581-589.e4 pubmed publisher

Li L, Roh J, Kim H, Park H, Kim M, Koh W, et al. The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction. Exp Neurobiol. 2019;28:329-336 pubmed publisher

Imanikia S, Özbey N, Krueger C, Casanueva M, Taylor R. Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans. Curr Biol. 2019;29:2322-2338.e7 pubmed publisher

Chandra S, Pahan K. Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer's Disease via Peroxisome Proliferator-Activated Receptor α. J Alzheimers Dis Rep. 2019;3:149-168 pubmed publisher

Baik S, Kang S, Lee W, Choi H, Chung S, Kim J, et al. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell Metab. 2019;30:493-507.e6 pubmed publisher

Harper M, Hedberg Buenz A, Herlein J, Abrahamson E, Anderson M, Kuehn M, et al. Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci. 2019;60:2716-2725 pubmed publisher

Paula P, Angelica Maria S, Luis C, Gloria Patricia C. Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model. Molecules. 2019;24: pubmed publisher

Sheng L, Chen M, Cai K, Song Y, Yu D, Zhang H, et al. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. FASEB J. 2019;33:10425-10442 pubmed publisher

Qin K, Zhao L, Gregory C, Solanki A, Mastrianni J. "Dual Disease" TgAD/GSS mice exhibit enhanced Alzheimer's disease pathology and reveal PrPC-dependent secretion of Aβ. Sci Rep. 2019;9:8524 pubmed publisher

Prakash P, Lantz T, Jethava K, Chopra G. Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid beta 1-42. Methods Protoc. 2019;2: pubmed publisher

Esquerda Canals G, Martí Clúa J, Villegas S. Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment. PLoS ONE. 2019;14:e0217793 pubmed publisher

Gulisano W, Melone M, Ripoli C, Rosaria Tropea M, Li Puma D, Giunta S, et al. Neuromodulatory action of picomolar extracellular Aβ42 oligomers on pre- and postsynaptic mechanisms underlying synaptic function and memory. J Neurosci. 2019;: pubmed publisher

Braggin J, Bucks S, Course M, Smith C, Sopher B, Osnis L, et al. Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Ann Clin Transl Neurol. 2019;6:762-777 pubmed publisher

Grant M, Shapiro S, Ashe K, Liu P, Zahs K. A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 2019;21:6 pubmed publisher

Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Rep. 2019;27:1293-1306.e6 pubmed publisher

Dyer M, Phipps A, Mitew S, Taberlay P, Woodhouse A. Age, but Not Amyloidosis, Induced Changes in Global Levels of Histone Modifications in Susceptible and Disease-Resistant Neurons in Alzheimer's Disease Model Mice. Front Aging Neurosci. 2019;11:68 pubmed publisher

Cecon E, Dam J, Luka M, Gautier C, Chollet A, Delagrange P, et al. Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor. Br J Pharmacol. 2019;176:3475-3488 pubmed publisher

Fowler A, Hebron M, Missner A, Wang R, Gao X, Kurd Misto B, et al. Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration. Drugs R D. 2019;19:149-166 pubmed publisher

Leonetti M, Grimaldi A, Ghirga S, Ruocco G, Antonacci G. Scattering Assisted Imaging. Sci Rep. 2019;9:4591 pubmed publisher

Lahiri S, Regis G, Koronyo Y, Fuchs D, Sheyn J, Kim E, et al. Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice. Crit Care. 2019;23:63 pubmed publisher

Yang P, Guo Y, Sun Y, Yu B, Zhang H, Wu J, et al. Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice. BMC Immunol. 2019;20:9 pubmed publisher

Huichalaf C, Al Ramahi I, Park K, Grunke S, Lu N, de Haro M, et al. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Hum Mol Genet. 2019;28:2014-2029 pubmed publisher

Fang E, Hou Y, Palikaras K, Adriaanse B, Kerr J, Yang B, et al. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci. 2019;22:401-412 pubmed publisher

Merlini M, Rafalski V, Rios Coronado P, Gill T, Ellisman M, Muthukumar G, et al. Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Neuron. 2019;101:1099-1108.e6 pubmed publisher

Stimmell A, Baglietto Vargas D, Moseley S, Lapointe V, Thompson L, LaFerla F, et al. Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease. Sci Rep. 2019;9:1311 pubmed publisher

Gerber H, Mosser S, Boury Jamot B, Stumpe M, Piersigilli A, Goepfert C, et al. The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta Neuropathol Commun. 2019;7:13 pubmed publisher

Zheng Y, Liu A, Wang Z, Cao Q, Wang W, Lin L, et al. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease. Brain. 2019;142:787-807 pubmed publisher

Limbocker R, Chia S, Ruggeri F, Perni M, Cascella R, Heller G, et al. Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nat Commun. 2019;10:225 pubmed publisher

Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisher

Hung C, Livesey F. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease. Cell Rep. 2018;25:3647-3660.e2 pubmed publisher

Keene C, Wilson A, Kilgore M, Bruner L, Postupna N, Darvas M. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest. 2018;: pubmed publisher

Cline E, Das A, Bicca M, Mohammad S, Schachner L, Kamel J, et al. A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies. J Neurochem. 2019;148:822-836 pubmed publisher

Dolfe L, Tambaro S, Tigro H, Del Campo M, Hoozemans J, Wiehager B, et al. The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques. J Alzheimers Dis Rep. 2018;2:27-39 pubmed publisher

Rosenberg R, Fu M, Lambracht Washington D. Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology. Alzheimers Res Ther. 2018;10:115 pubmed publisher

Bartolotti N, Disouky A, Kalinski A, Elmann A, Lazarov O. Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism. J Alzheimers Dis. 2018;66:1425-1435 pubmed publisher

Barykin E, Petrushanko I, Kozin S, Telegin G, CHERNOV A, Lopina O, et al. Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition. Front Mol Neurosci. 2018;11:302 pubmed publisher

Kozin S, Barykin E, Telegin G, CHERNOV A, Adzhubei A, Radko S, et al. Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer's Disease. Front Neurosci. 2018;12:518 pubmed publisher

Ahmad F, Das D, Kommaddi R, Diwakar L, Gowaikar R, Rupanagudi K, et al. Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. Sci Rep. 2018;8:13119 pubmed publisher

Gonzalez C, Armijo E, Bravo Alegria J, Becerra Calixto A, Mays C, Soto C. Modeling amyloid beta and tau pathology in human cerebral organoids. Mol Psychiatry. 2018;23:2363-2374 pubmed publisher

Rubio Araiz A, Finucane O, Keogh S, Lynch M. Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid. J Neuroinflammation. 2018;15:247 pubmed publisher

Khan I, Krishnaswamy S, Sabale M, Groth D, Wijaya L, Morici M, et al. Efficient production of a mature and functional gamma secretase protease. Sci Rep. 2018;8:12834 pubmed publisher

Edler M, Sherwood C, Meindl R, Munger E, Hopkins W, Ely J, et al. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. J Comp Neurol. 2018;526:2921-2936 pubmed publisher

Bearer E, Manifold Wheeler B, Medina C, Gonzales A, Chaves F, Jacobs R. Alterations of functional circuitry in aging brain and the impact of mutated APP expression. Neurobiol Aging. 2018;70:276-290 pubmed publisher

Goodman J, Adham Z, Woltjer R, Lund A, Iliff J. Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects. Brain Behav Immun. 2018;73:34-40 pubmed publisher

Wang D, Zhang X, Wang M, Zhou D, Pan H, Shu Q, et al. Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer's Disease. Neurosci Bull. 2018;34:912-920 pubmed publisher

Chernick D, Ortiz Valle S, Jeong A, Swaminathan S, Kandimalla K, Rebeck G, et al. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. J Neurochem. 2018;147:647-662 pubmed publisher

Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson M. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiol Aging. 2018;70:160-169 pubmed publisher

Herzer S, Hagan C, von Gerichten J, Dieterle V, Munteanu B, Sandhoff R, et al. Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer's Disease. Front Mol Neurosci. 2018;11:206 pubmed publisher

Chandra S, Jana M, Pahan K. Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα. J Neurosci. 2018;38:6682-6699 pubmed publisher

Roitenberg N, Bejerano Sagie M, Boocholez H, Moll L, Marques F, Golodetzki L, et al. Modulation of caveolae by insulin/IGF-1 signaling regulates aging of Caenorhabditis elegans. EMBO Rep. 2018;19: pubmed publisher

Readhead B, Haure Mirande J, Funk C, Richards M, Shannon P, Haroutunian V, et al. Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron. 2018;99:64-82.e7 pubmed publisher

Opazo P, Viana da Silva S, Carta M, Breillat C, Coultrap S, Grillo Bosch D, et al. CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity. Cell Rep. 2018;23:3137-3145 pubmed publisher

Spitzer P, Lang R, Oberstein T, Lewczuk P, Ermann N, Huttner H, et al. A Specific Reduction in Aβ1-42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis. Front Aging Neurosci. 2018;10:152 pubmed publisher

Dong Z, Li J, Gan Y, Sun X, Leng Y, Ge J. Amyloid beta deposition related retinal pigment epithelium cell impairment and subretinal microglia activation in aged APPswePS1 transgenic mice. Int J Ophthalmol. 2018;11:747-755 pubmed publisher

Zhang J, Yu L, Yang H, Hui Z, Jiang S, Chen L, et al. Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing A? deposition. BMC Complement Altern Med. 2018;18:167 pubmed publisher

Vargas Restrepo F, Sabogal Guáqueta A, Cardona Gómez G. [Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]. Biomedica. 2018;38:69-76 pubmed publisher

Serra Batiste M, Tolchard J, Giusti F, Zoonens M, Carulla N. Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease. Front Mol Biosci. 2018;5:38 pubmed publisher

Van der Jeugd A, Parra Damas A, Baeta Corral R, Soto Faguás C, Ahmed T, LaFerla F, et al. Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice. Sci Rep. 2018;8:6431 pubmed publisher

Jonson M, Nyström S, Sandberg A, Carlback M, Michno W, Hanrieder J, et al. Aggregated Aβ1-42 Is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila. Cell Chem Biol. 2018;25:595-610.e5 pubmed publisher

Wendeln A, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556:332-338 pubmed publisher

Söllvander S, Nikitidou E, Gallasch L, Zysk M, Söderberg L, Sehlin D, et al. The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death. J Neuroinflammation. 2018;15:98 pubmed publisher

Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Yokoyama I, et al. Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice. J Neuroimmunol. 2018;319:80-92 pubmed publisher

Yan T, Wang L, Gao J, Siedlak S, Huntley M, Termsarasab P, et al. Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease. J Alzheimers Dis. 2018;63:157-165 pubmed publisher

Datta M, Staszewski O, Raschi E, Frosch M, Hagemeyer N, Tay T, et al. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. 2018;48:514-529.e6 pubmed publisher

Sachdev R, Kappes Horn K, Paulsen L, Duernberger Y, Pleschka C, Denner P, et al. Endoplasmic Reticulum Stress Induces Myostatin High Molecular Weight Aggregates and Impairs Mature Myostatin Secretion. Mol Neurobiol. 2018;55:8355-8373 pubmed publisher

Song M, Song K, Kim S, Lee J, Hwang S, Han C. Caenorhabditis elegans BRICHOS Domain-Containing Protein C09F5.1 Maintains Thermotolerance and Decreases Cytotoxicity of Aβ42 by Activating the UPR. Genes (Basel). 2018;9: pubmed publisher

Matthes F, Hettich M, Schilling J, Flores Dominguez D, Blank N, Wiglenda T, et al. Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis. Cell Death Discov. 2018;4:4 pubmed publisher

Turnbull M, Boskovic Z, Coulson E. Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion. Front Mol Neurosci. 2018;11:51 pubmed publisher

Zhang L, Trushin S, Christensen T, Tripathi U, Hong C, Geroux R, et al. Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane. Neurobiol Dis. 2018;114:1-16 pubmed publisher

di Fede G, Catania M, Maderna E, Ghidoni R, Benussi L, Tonoli E, et al. Molecular subtypes of Alzheimer's disease. Sci Rep. 2018;8:3269 pubmed publisher

Casali B, Reed Geaghan E, Landreth G. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease. J Neuroinflammation. 2018;15:43 pubmed publisher

Batarseh Y, Kaddoumi A. Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease. J Nutr Biochem. 2018;55:113-123 pubmed publisher

Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, et al. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 2018;13:6 pubmed publisher

Park J, Kim H, Lee J, Park J, Kim J, Hwang K, et al. Amyloid Beta Detection by Faradaic Electrochemical Impedance Spectroscopy Using Interdigitated Microelectrodes. Sensors (Basel). 2018;18: pubmed publisher

Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, et al. Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep. 2018;8:1329 pubmed publisher

Chandramowlishwaran P, Sun M, Casey K, Romanyuk A, Grizel A, Sopova J, et al. Mammalian amyloidogenic proteins promote prion nucleation in yeast. J Biol Chem. 2018;293:3436-3450 pubmed publisher

Lim C, Han J. The antioxidant xanthorrhizol prevents amyloid-?-induced oxidative modification and inactivation of neprilysin. Biosci Rep. 2018;38: pubmed publisher

Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, et al. Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations. J Neuropathol Exp Neurol. 2018;77:128-138 pubmed publisher

Asam K, Staniszewski A, Zhang H, Melideo S, Mazzeo A, Voronkov M, et al. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. PLoS ONE. 2017;12:e0189413 pubmed publisher

Ziegler Waldkirch S, d Errico P, Sauer J, Erny D, Savanthrapadian S, Loreth D, et al. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease. EMBO J. 2018;37:167-182 pubmed publisher

Welty S, Teng Y, Liang Z, Zhao W, Sanders L, Greenamyre J, et al. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem. 2018;293:1353-1362 pubmed publisher

Huynh T, Liao F, Francis C, Robinson G, Serrano J, Jiang H, et al. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron. 2017;96:1013-1023.e4 pubmed publisher

Buccarello L, Sclip A, Sacchi M, Castaldo A, Bertani I, ReCecconi A, et al. The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies. Oncotarget. 2017;8:83038-83051 pubmed publisher

Chaney A, Bauer M, Bochicchio D, Smigova A, Kassiou M, Davies K, et al. Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe ×PS1?e9 transgenic mouse model of Alzheimer's disease. J Neurochem. 2017;: pubmed publisher

Park J, Kwon J, Kim N, Song K. Effects of 1950 MHz radiofrequency electromagnetic fields on A? processing in human neuroblastoma and mouse hippocampal neuronal cells. J Radiat Res. 2017;:1-9 pubmed publisher

Pera M, Larrea D, Guardia Laguarta C, Montesinos J, Velasco K, Agrawal R, et al. Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. EMBO J. 2017;36:3356-3371 pubmed publisher

Yang C, Cai C, Song J, Tan J, Durairajan S, Iyaswamy A, et al. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 2017;13:2028-2040 pubmed publisher

Chen L, Li G, Li Y, Li Y, Zhu H, Tang L, et al. UbasM: An effective balanced optical clearing method for intact biomedical imaging. Sci Rep. 2017;7:12218 pubmed publisher

O Reilly M, Jones R, Barrett E, Schwab A, Head E, Hynynen K. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017;7:3573-3584 pubmed publisher

Zhi D, Wang D, Yang W, Duan Z, Zhu S, Dong J, et al. Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans. Sci Rep. 2017;7:11408 pubmed publisher

Colvin B, Rogers V, Kulas J, Ridgway E, Amtashar F, Combs C, et al. The conformational epitope for a new A?42 protofibril-selective antibody partially overlaps with the peptide N-terminal region. J Neurochem. 2017;143:736-749 pubmed publisher

Yadav D, Maloney J, Wildsmith K, Fuji R, Meilandt W, Solanoy H, et al. Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates. Br J Pharmacol. 2017;174:4173-4185 pubmed publisher

Bove Fenderson E, Urano R, Straub J, Harris D. Cellular prion protein targets amyloid-? fibril ends via its C-terminal domain to prevent elongation. J Biol Chem. 2017;292:16858-16871 pubmed publisher

Willén K, Edgar J, Hasegawa T, Tanaka N, Futter C, Gouras G. A? accumulation causes MVB enlargement and is modelled by dominant negative VPS4A. Mol Neurodegener. 2017;12:61 pubmed publisher

Sogorb Esteve A, García Ayllón M, Llansola M, Felipo V, Blennow K, Saez Valero J. Inhibition of γ-Secretase Leads to an Increase in Presenilin-1. Mol Neurobiol. 2018;55:5047-5058 pubmed publisher

Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher

Zhu X, Wang S, Yu L, Jin J, Ye X, Liu Y, et al. HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease. Aging Cell. 2017;16:1073-1082 pubmed publisher

Li N, Hu P, Xu T, Chen H, Chen X, Hu J, et al. iTRAQ-based Proteomic Analysis of APPSw,Ind Mice Provides Insights into the Early Changes in Alzheimer's Disease. Curr Alzheimer Res. 2017;14:1109-1122 pubmed publisher

Kulas J, Puig K, Combs C. Amyloid precursor protein in pancreatic islets. J Endocrinol. 2017;235:49-67 pubmed publisher

Plá V, Barranco N, Pozas E, Aguado F. Amyloid-β Impairs Vesicular Secretion in Neuronal and Astrocyte Peptidergic Transmission. Front Mol Neurosci. 2017;10:202 pubmed publisher

Kedia N, Almisry M, Bieschke J. Glucose directs amyloid-beta into membrane-active oligomers. Phys Chem Chem Phys. 2017;19:18036-18046 pubmed publisher

Sebollela A, Cline E, Popova I, Luo K, Sun X, Ahn J, et al. A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers. J Neurochem. 2017;142:934-947 pubmed publisher

Hu X, Hu Z, Li Z, Ruan C, Qiu W, Pan A, et al. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum. Front Neuroanat. 2017;11:45 pubmed publisher

Finke J, Ayres K, Brisbin R, Hill H, Wing E, Banks W. Antibody blood-brain barrier efflux is modulated by glycan modification. Biochim Biophys Acta Gen Subj. 2017;1861:2228-2239 pubmed publisher

Wang X, Song R, Lu W, Liu Z, Wang L, Zhu X, et al. YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice. Front Aging Neurosci. 2017;9:157 pubmed publisher

Xia F, Yiu A, Stone S, Oh S, Lozano A, Josselyn S, et al. Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease. Neuropsychopharmacology. 2017;42:2493-2503 pubmed publisher

López Arias B, Turiegano E, Monedero I, Canal I, Torroja L. Presynaptic Aβ40 prevents synapse addition in the adult Drosophila neuromuscular junction. PLoS ONE. 2017;12:e0177541 pubmed publisher

Amar F, Sherman M, Rush T, LARSON M, Boyle G, Chang L, et al. The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation. Sci Signal. 2017;10: pubmed publisher

Valls Comamala V, Guivernau B, Bonet J, Puig M, Perálvarez Marín A, Palomer E, et al. The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers. Oncotarget. 2017;8:41154-41165 pubmed publisher

Baek S, Park S, Jeong J, Kim S, Han J, Kyung J, et al. Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model. J Neurosci. 2017;37:5099-5110 pubmed publisher

Abud E, Ramirez R, Martinez E, Healy L, Nguyen C, Newman S, et al. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017;94:278-293.e9 pubmed publisher

Batarseh Y, Mohamed L, Al Rihani S, Mousa Y, Siddique A, El Sayed K, et al. Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies. Neuroscience. 2017;352:204-215 pubmed publisher

Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun. 2017;5:26 pubmed publisher

Kirouac L, Rajic A, Cribbs D, Padmanabhan J. Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease. Eneuro. 2017;4: pubmed publisher

Nobili A, Latagliata E, Viscomi M, Cavallucci V, Cutuli D, Giacovazzo G, et al. Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease. Nat Commun. 2017;8:14727 pubmed publisher

Lin T, Chang C, Chang Y, Liao Y, Yu H, Chen Y. Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity. PLoS ONE. 2017;12:e0174561 pubmed publisher

Garcia Esparcia P, Lopez Gonzalez I, Grau Rivera O, García Garrido M, Konetti A, Llorens F, et al. Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms. Front Neurol. 2017;8:89 pubmed publisher

Croft C, Wade M, Kurbatskaya K, Mastrandreas P, Hughes M, Phillips E, et al. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis. 2017;8:e2671 pubmed publisher

Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, et al. Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease. Antioxid Redox Signal. 2017;27:1269-1280 pubmed publisher

Poksay K, Sheffler D, Spilman P, Campagna J, Jagodzinska B, Descamps O, et al. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017;8:46 pubmed publisher

Harach T, Marungruang N, Duthilleul N, Cheatham V, Mc Coy K, Frisoni G, et al. Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep. 2017;7:41802 pubmed publisher

Schmidt K, Wienken M, Keller C, Balcarek P, MUNZ C, Schmidt J. IL-1β-Induced Accumulation of Amyloid: Macroautophagy in Skeletal Muscle Depends on ERK. Mediators Inflamm. 2017;2017:5470831 pubmed publisher

Ye X, Feng T, Tammineni P, Chang Q, Jeong Y, Margolis D, et al. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease. J Neurosci. 2017;37:2639-2655 pubmed publisher

Augé E, Cabezón I, Pelegri C, Vilaplana J. New perspectives on corpora amylacea in the human brain. Sci Rep. 2017;7:41807 pubmed publisher

Vu H, Akatsu H, Hashizume Y, Setou M, Ikegami K. Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease. Sci Rep. 2017;7:40205 pubmed publisher

Flanagan M, Marshall D, Shofer J, Montine K, Nelson P, Montine T, et al. Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease. J Neuropathol Exp Neurol. 2017;76:39-43 pubmed publisher

Feng T, Tammineni P, Agrawal C, Jeong Y, Cai Q. Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation. J Biol Chem. 2017;292:1679-1690 pubmed publisher

Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, et al. Young microglia restore amyloid plaque clearance of aged microglia. EMBO J. 2017;36:583-603 pubmed publisher

Kaya I, Brinet D, Michno W, Syvänen S, Sehlin D, Zetterberg H, et al. Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry. ACS Chem Neurosci. 2017;8:347-355 pubmed publisher

Reinders N, Pao Y, Renner M, Da Silva Matos C, Lodder T, Malinow R, et al. Amyloid-? effects on synapses and memory require AMPA receptor subunit GluA3. Proc Natl Acad Sci U S A. 2016;113:E6526-E6534 pubmed

Pan H, Wang D, Zhang X, Zhou D, Zhang H, Qian Q, et al. Amyloid ? Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein. Stem Cell Reports. 2016;7:707-718 pubmed publisher

Kimura A, Hata S, Suzuki T. Alternative Selection of ?-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid ?-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the A? Sequence. J Biol Chem. 2016;291:24041-24053 pubmed

Sherman M, LaCroix M, Amar F, Larson M, Forster C, Aguzzi A, et al. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci. 2016;36:9647-58 pubmed publisher

Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher

Hernandez Rapp J, Rainone S, Goupil C, Dorval V, Smith P, Saint Pierre M, et al. microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. Sci Rep. 2016;6:30953 pubmed publisher

Hostetler E, Walji A, Zeng Z, Miller P, Bennacef I, Salinas C, et al. Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles. J Nucl Med. 2016;57:1599-1606 pubmed

Donner L, Fälker K, Gremer L, Klinker S, Pagani G, Ljungberg L, et al. Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release. Sci Signal. 2016;9:ra52 pubmed publisher

Fu A, Hung K, Yuen M, Zhou X, Mak D, Chan I, et al. IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Proc Natl Acad Sci U S A. 2016;113:E2705-13 pubmed publisher

Cifelli J, Dozier L, Chung T, Patrick G, Yang J. Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons. J Biol Chem. 2016;291:11981-92 pubmed publisher

Omata Y, Tharasegaran S, Lim Y, Yamasaki Y, Ishigaki Y, Tatsuno T, et al. Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception. Aging (Albany NY). 2016;8:427-39 pubmed

Baruch K, Deczkowska A, Rosenzweig N, Tsitsou Kampeli A, Sharif A, Matcovitch Natan O, et al. PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease. Nat Med. 2016;22:135-7 pubmed publisher

Sandoval Hernández A, Buitrago L, Moreno H, Cardona Gómez G, Arboleda G. Role of Liver X Receptor in AD Pathophysiology. PLoS ONE. 2015;10:e0145467 pubmed publisher

Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher

Liu P, Reed M, Kotilinek L, Grant M, Forster C, Qiang W, et al. Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Rep. 2015;11:1760-71 pubmed publisher

Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher

Gowert N, Donner L, Chatterjee M, Eisele Y, Towhid S, Münzer P, et al. Blood platelets in the progression of Alzheimer's disease. PLoS ONE. 2014;9:e90523 pubmed publisher

Zheng Y, Wang Q, Xiao B, Lu Q, Wang Y, Wang X. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and ?-amyloid deposition in Alzheimer's disease models. PLoS ONE. 2012;7:e39035 pubmed publisher

Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed publisher

Thakker D, Weatherspoon M, Harrison J, Keene T, Lane D, KAEMMERER W, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2009;106:4501-6 pubmed publisher

Oddo S, Caccamo A, Green K, Liang K, Tran L, Chen Y, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005;102:3046-51 pubmed

Herzig M, Winkler D, Burgermeister P, Pfeifer M, Kohler E, Schmidt S, et al. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004;7:954-60 pubmed