product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified (azide-free) anti-β-Amyloid, 1-16
catalog :
803001
quantity :
200 μL
price :
554 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6E10
reactivity :
African green monkey, hamsters, human, mouse, rat, fruit fly
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other
more info or order :
citations: 334
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 6a
Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
  • western blot; mouse; 1:500; loading ...
Emre C, Do K, Jun B, Hjorth E, Alcalde S, Kautzmann M, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:116 pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 1c
Sha S, Shen X, Cao Y, Qu L. Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer's disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway. Aging (Albany NY). 2021;13:15285-15306 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 2b
Doré K, Carrico Z, Alfonso S, Marino M, Koymans K, Kessels H, et al. PSD-95 protects synapses from β-amyloid. Cell Rep. 2021;35:109194 pubmed publisher
  • ELISA; mouse
Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; fig 2a
Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4d
Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, et al. The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathol Commun. 2021;9:6 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1h
Hashimoto T, Fujii D, Naka Y, Kashiwagi Hakozaki M, Matsuo Y, Matsuura Y, et al. Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques. Acta Neuropathol Commun. 2020;8:212 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...
Gonzalo Gobernado R, Perucho J, Vallejo Muñoz M, Casarejos M, Reimers D, Jimenez Escrig A, et al. Liver Growth Factor "LGF" as a Therapeutic Agent for Alzheimer's Disease. Int J Mol Sci. 2020;21: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...
Lin L, Petralia R, Lake R, Wang Y, Hoffman D. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3e, 6b
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 8a
Lackie R, Marques Lopes J, Ostapchenko V, Good S, Choy W, van Oosten Hawle P, et al. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:143 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 5c
Kazuki Y, Gao F, Li Y, Moyer A, Devenney B, Hiramatsu K, et al. A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1b
Wander C, Tseng J, Song S, Al Housseiny H, Tart D, Ajit A, et al. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. 2020;23:101255 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 2a
Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, et al. Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress. Oxid Med Cell Longev. 2020;2020:3050971 pubmed publisher
  • other; rat; fig 1
Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, et al. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 2020;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 4h
Rodriguez Ortiz C, Prieto G, Martini A, Forner S, Trujillo Estrada L, LaFerla F, et al. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13118 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:2000; loading ...; fig 3a
Barros Viegas A, Carmona V, Ferreiro E, Guedes J, Cardoso A, Cunha P, et al. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease. Mol Ther Nucleic Acids. 2020;19:1219-1236 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 2c
Tambini M, Norris K, D ADAMIO L. Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation. elife. 2020;9: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2a
Eede P, Obst J, Benke E, Yvon Durocher G, Richard B, Gimber N, et al. Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice. EMBO Rep. 2020;21:e48530 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Oh S, Kim J, Park S, Lee J. Associative Interactions among Zinc, Apolipoprotein E, and Amyloid-β in the Amyloid Pathology. Int J Mol Sci. 2020;21: pubmed publisher
  • other; mouse; 1:2000; loading ...
Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. J Neurosci. 2020;40:1956-1974 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000; loading ...; fig 1
Walker D, Tang T, Mendsaikhan A, Tooyama I, Serrano G, Sue L, et al. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. Int J Mol Sci. 2020;21: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 2a, 2b
  • western blot; human; loading ...; fig 2g
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2c, 2d
  • western blot; mouse; loading ...; fig 2h
Yan T, Liang J, Gao J, Wang L, Fujioka H, Zhu X, et al. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nat Commun. 2020;11:411 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...; fig 5a
Pi G, Gao D, Wu D, Wang Y, Lei H, Zeng W, et al. Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect. Nat Commun. 2020;11:183 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3s1
  • western blot; mouse; 1:1000; loading ...; fig 6e
El Gaamouch F, Audrain M, Lin W, Beckmann N, Jiang C, Hariharan S, et al. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Mol Neurodegener. 2020;15:4 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:4000; loading ...; fig 2b
Pires G, McElligott S, Drusinsky S, Halliday G, Potier M, Wisniewski T, et al. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathol Commun. 2019;7:195 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:2000; loading ...; fig 7b
Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, et al. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls. elife. 2019;8: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig s1
Hansson O, Svensson M, Gustavsson A, Andersson E, Yang Y, Nagga K, et al. Midlife physical activity is associated with lower incidence of vascular dementia but not Alzheimer's disease. Alzheimers Res Ther. 2019;11:87 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2500; loading ...; fig 4a
Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 1a
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler R, Zhang S, et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22:719-728 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Pan R, Ma J, Kong X, Wang X, Li S, Qi X, et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance. Sci Adv. 2019;5:eaau6328 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 1b
Michno W, Nyström S, Wehrli P, Lashley T, Brinkmalm G, Guerard L, et al. Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology. J Biol Chem. 2019;294:6719-6732 pubmed publisher
  • western blot; mouse; 1:11,000; loading ...; fig 3b
Sri S, Pegasiou C, Cave C, Hough K, Wood N, Gomez Nicola D, et al. Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2019;7:25 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 4f
Lahiri S, Regis G, Koronyo Y, Fuchs D, Sheyn J, Kim E, et al. Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice. Crit Care. 2019;23:63 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2f
Gerber H, Mosser S, Boury Jamot B, Stumpe M, Piersigilli A, Goepfert C, et al. The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta Neuropathol Commun. 2019;7:13 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...; fig 2d
Rosenzweig N, Dvir Szternfeld R, Tsitsou Kampeli A, Keren Shaul H, Ben Yehuda H, Weill Raynal P, et al. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model. Nat Commun. 2019;10:465 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3c
Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
  • western blot; human; loading ...; fig s3g
Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
  • immunohistochemistry; mouse; loading ...; fig 3b
Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2e
Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson M. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiol Aging. 2018;70:160-169 pubmed publisher
  • western blot; human; loading ...; fig 3a
Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Mol Psychiatry. 2018;: pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig 1a
Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6c
  • western blot; mouse; 1:1000; loading ...; fig 8b
Barbero Camps E, Roca Agujetas V, Bartolessis I, de Dios C, Fernandez Checa J, Mari M, et al. Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion. Autophagy. 2018;14:1129-1154 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s1
Wendeln A, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556:332-338 pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 1b
Chiang A, Fowler S, Savjani R, Hilsenbeck S, Wallace C, Cirrito J, et al. Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med. 2018;215:1349-1364 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 3a
Casali B, Reed Geaghan E, Landreth G. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease. J Neuroinflammation. 2018;15:43 pubmed publisher
  • western blot; human; loading ...; fig 1a
Mukadam A, Breusegem S, Seaman M. Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing. Cell Mol Life Sci. 2018;75:2613-2625 pubmed publisher
  • immunohistochemistry - frozen section; African green monkey; 1:12,000; loading ...; fig 4a
Cramer P, Gentzel R, Tanis K, Vardigan J, Wang Y, Connolly B, et al. Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease. Neurobiol Aging. 2018;64:92-106 pubmed publisher
  • western blot; mouse; 1:2500; loading ...; fig 5a
Chiang A, Fowler S, Reddy R, Pletnikova O, Troncoso J, Sherman M, et al. Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018;188:739-756 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:3000; loading ...; fig 1a
Ziegler Waldkirch S, d Errico P, Sauer J, Erny D, Savanthrapadian S, Loreth D, et al. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease. EMBO J. 2018;37:167-182 pubmed publisher
  • western blot; human; fig 2a
Benvegnù S, Wahle T, Dotti C. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget. 2017;8:89439-89450 pubmed publisher
  • immunocytochemistry; rat; 1:1000; loading ...; fig 7a
Íñigo Marco I, Valencia M, Larrea L, Bugallo R, Martínez Goikoetxea M, Zuriguel I, et al. E46K ?-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation. Proc Natl Acad Sci U S A. 2017;114:E8274-E8283 pubmed publisher
  • immunohistochemistry - frozen section; African green monkey; 1:7500; loading ...; fig 1a
Edler M, Sherwood C, Meindl R, Hopkins W, Ely J, Erwin J, et al. Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease. Neurobiol Aging. 2017;59:107-120 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 6a
  • western blot; human; loading ...; fig s1a
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s5b
Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 2a
Siedlak S, Jiang Y, Huntley M, Wang L, Gao J, Xie F, et al. TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease. J Alzheimers Dis. 2017;58:1027-1033 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 4a
Koistinen N, Edlund A, Menon P, Ivanova E, Bacanu S, Iverfeldt K. Nuclear localization of amyloid-? precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis. PLoS ONE. 2017;12:e0173888 pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig 4j
Gardenal E, Chiarini A, Armato U, Dal Pra I, Verkhratsky A, Rodriguez J. Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease. Front Neurosci. 2017;11:81 pubmed publisher
  • immunohistochemistry; human; 1:1000; loading ...; fig 5a
Zheng T, Pu J, Chen Y, Mao Y, Guo Z, Pan H, et al. Plasma Exosomes Spread and Cluster Around ?-Amyloid Plaques in an Animal Model of Alzheimer's Disease. Front Aging Neurosci. 2017;9:12 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1e
Mellott T, Huleatt O, Shade B, Pender S, Liu Y, Slack B, et al. Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS ONE. 2017;12:e0170450 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 5b
Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1d
  • western blot; mouse; 1:1000; loading ...; fig 1f
Yang S, Lee D, Shin J, Lee S, Baek S, Kim J, et al. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO Mol Med. 2017;9:61-77 pubmed publisher
  • western blot; human; loading ...; fig 3b
Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; fig 3
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed publisher
  • western blot; mouse; fig 4
Xu J, De Winter F, Farrokhi C, Rockenstein E, Mante M, Adame A, et al. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep. 2016;6:31692 pubmed publisher
  • western blot; human; 1:2000; fig 2
Marzesco A, Flötenmeyer M, Bühler A, Obermüller U, Staufenbiel M, Jucker M, et al. Highly potent intracellular membrane-associated A? seeds. Sci Rep. 2016;6:28125 pubmed publisher
  • western blot; human; fig 1
Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, et al. Deacetylation of TFEB promotes fibrillar A? degradation by upregulating lysosomal biogenesis in microglia. Protein Cell. 2016;7:417-33 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 3
  • western blot; mouse; 1:1000; fig 3
Lee K, Lee H, Lin H, Tsay H, Tsai F, Shyue S, et al. Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease. J Neuroinflammation. 2016;13:92 pubmed publisher
  • western blot; fruit fly ; fig 1
Ando K, Maruko Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima K. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity. PLoS Genet. 2016;12:e1005917 pubmed publisher
  • immunoprecipitation; human; fig 4
Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed publisher
  • immunohistochemistry - free floating section; human; 1:1000; tbl 2
Perez S, Sherwood C, Cranfield M, Erwin J, Mudakikwa A, Hof P, et al. Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol Aging. 2016;39:195-201 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 4
  • western blot; mouse; 1:1000; fig 4
Peng Y, Kim M, Hullinger R, O Riordan K, Burger C, Pehar M, et al. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain. 2016;139:937-52 pubmed publisher
  • western blot; human; 1:1000; tbl 1
  • western blot; mouse; 1:1000; tbl 1
Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
  • western blot; hamsters; fig 7
Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  • western blot; fruit fly ; 1:2000; fig 2O
Lee S, Bang S, Hong Y, Lee J, Jeong H, Park S, et al. The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease. Dis Model Mech. 2016;9:295-306 pubmed publisher
  • western blot; mouse; fig s5
De Mario A, Castellani A, Peggion C, Massimino M, Lim D, Hill A, et al. The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase. Front Cell Neurosci. 2015;9:416 pubmed publisher
  • western blot; human; 1:1500; fig 3
  • western blot; mouse; 1:1500; fig 3
Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed publisher
  • western blot; mouse; 1:2000; fig 5e
Ostapchenko V, Chen M, Guzman M, Xie Y, Lavine N, Fan J, et al. The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J Neurosci. 2015;35:15157-69 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 4
Sabogal Guáqueta A, Osorio E, Cardona Gómez G. Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice. Neuropharmacology. 2016;102:111-20 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 1
Cherry J, Olschowka J, O Banion M. Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation. J Neuroinflammation. 2015;12:203 pubmed publisher
  • western blot; human; 1:1000
Kumar R, Nordberg A, Darreh Shori T. Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs. Brain. 2016;139:174-92 pubmed publisher
  • ELISA; human; 2 ug/ml; fig 6
Miners J, Palmer J, Love S. Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease. Brain Pathol. 2016;26:533-41 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Kokiko Cochran O, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, et al. Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Neurotrauma. 2016;33:625-40 pubmed publisher
  • immunohistochemistry; human; tbl 1
Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher
  • western blot; fruit fly
Nevzglyadova O, Mikhailova E, Amen T, Zenin V, Artemov A, Kostyleva E, et al. Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster. Amyloid. 2015;22:100-11 pubmed publisher
  • other; human; 1:100; loading ...; fig 2a
Cuddy L, Seah C, Pasternak S, Rylett R. Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein. J Neurochem. 2015;134:769-82 pubmed publisher
  • western blot; mouse; 1:2500
Liu P, Paulson J, Forster C, Shapiro S, Ashe K, Zahs K. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS ONE. 2015;10:e0126317 pubmed publisher
  • immunoprecipitation; human
Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Yetman M, Lillehaug S, Bjaalie J, Leergaard T, Jankowsky J. Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex. Brain Struct Funct. 2016;221:2231-49 pubmed publisher
  • western blot; mouse; 1:2000
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product information
Antigen :
beta-Amyloid 1-16
Apps. Abbrev. :
Western Blotting, Direct ELISA, IHC-P, IHC-F, EM, ICC
Cat # :
803001
Clone :
6E10
Item :
Purified (azide-free) anti-β-Amyloid, 1-16
Isotype :
Mouse IgG1, κ
Other Names :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Size :
200 μL
Price (USD) :
554 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PUREAF
Application Notes :
This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). This antibody clone has been reported for use in immunohistochemistry of free-floating sections 2,13 .
more info or order :
company information
BioLegend
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customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA