Published Application/Species/Sample/Dilution | Reference |
---|
- immunohistochemistry; mouse; loading ...; fig 6a
| Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
|
- western blot; mouse; 1:500; loading ...
| Emre C, Do K, Jun B, Hjorth E, Alcalde S, Kautzmann M, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:116 pubmed publisher
|
- immunohistochemistry; rat; loading ...; fig 1c
| Sha S, Shen X, Cao Y, Qu L. Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer's disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway. Aging (Albany NY). 2021;13:15285-15306 pubmed publisher
|
- western blot; rat; 1:1000; loading ...; fig 2b
| Doré K, Carrico Z, Alfonso S, Marino M, Koymans K, Kessels H, et al. PSD-95 protects synapses from β-amyloid. Cell Rep. 2021;35:109194 pubmed publisher
|
| Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher
|
- immunohistochemistry; human; 1:500; loading ...; fig 2a
| Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
|
- immunohistochemistry; mouse; 1:500; loading ...; fig 4d
| Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, et al. The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathol Commun. 2021;9:6 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 1h
| Hashimoto T, Fujii D, Naka Y, Kashiwagi Hakozaki M, Matsuo Y, Matsuura Y, et al. Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques. Acta Neuropathol Commun. 2020;8:212 pubmed publisher
|
- immunohistochemistry; mouse; 1:100; loading ...
| Gonzalo Gobernado R, Perucho J, Vallejo Muñoz M, Casarejos M, Reimers D, Jimenez Escrig A, et al. Liver Growth Factor "LGF" as a Therapeutic Agent for Alzheimer's Disease. Int J Mol Sci. 2020;21: pubmed publisher
|
- immunohistochemistry; mouse; 1:1000; loading ...
| Lin L, Petralia R, Lake R, Wang Y, Hoffman D. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197 pubmed publisher
|
- immunohistochemistry; mouse; 1:200; loading ...; fig 3e, 6b
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 8a
| Lackie R, Marques Lopes J, Ostapchenko V, Good S, Choy W, van Oosten Hawle P, et al. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:143 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 5c
| Kazuki Y, Gao F, Li Y, Moyer A, Devenney B, Hiramatsu K, et al. A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21. elife. 2020;9: pubmed publisher
|
- immunohistochemistry; mouse; loading ...; fig 1b
| Wander C, Tseng J, Song S, Al Housseiny H, Tart D, Ajit A, et al. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. 2020;23:101255 pubmed publisher
|
- immunohistochemistry; mouse; 1:400; loading ...; fig 2a
| Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, et al. Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress. Oxid Med Cell Longev. 2020;2020:3050971 pubmed publisher
|
| Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, et al. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 2020;10: pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 4h
| Rodriguez Ortiz C, Prieto G, Martini A, Forner S, Trujillo Estrada L, LaFerla F, et al. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020;19:e13118 pubmed publisher
|
- immunohistochemistry - free floating section; mouse; 1:2000; loading ...; fig 3a
| Barros Viegas A, Carmona V, Ferreiro E, Guedes J, Cardoso A, Cunha P, et al. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease. Mol Ther Nucleic Acids. 2020;19:1219-1236 pubmed publisher
|
- western blot; rat; 1:1000; loading ...; fig 2c
| Tambini M, Norris K, D ADAMIO L. Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation. elife. 2020;9: pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2a
| Eede P, Obst J, Benke E, Yvon Durocher G, Richard B, Gimber N, et al. Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice. EMBO Rep. 2020;21:e48530 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 3a
| Oh S, Kim J, Park S, Lee J. Associative Interactions among Zinc, Apolipoprotein E, and Amyloid-β in the Amyloid Pathology. Int J Mol Sci. 2020;21: pubmed publisher
|
- other; mouse; 1:2000; loading ...
| Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. J Neurosci. 2020;40:1956-1974 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:2000; loading ...; fig 1
| Walker D, Tang T, Mendsaikhan A, Tooyama I, Serrano G, Sue L, et al. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. Int J Mol Sci. 2020;21: pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 2a, 2b
- western blot; human; loading ...; fig 2g
- immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2c, 2d
- western blot; mouse; loading ...; fig 2h
| Yan T, Liang J, Gao J, Wang L, Fujioka H, Zhu X, et al. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nat Commun. 2020;11:411 pubmed publisher
|
- immunohistochemistry; mouse; 1:300; loading ...; fig 5a
| Pi G, Gao D, Wu D, Wang Y, Lei H, Zeng W, et al. Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect. Nat Commun. 2020;11:183 pubmed publisher
|
- immunohistochemistry; mouse; 1:1000; loading ...; fig 3s1
- western blot; mouse; 1:1000; loading ...; fig 6e
| El Gaamouch F, Audrain M, Lin W, Beckmann N, Jiang C, Hariharan S, et al. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Mol Neurodegener. 2020;15:4 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:4000; loading ...; fig 2b
| Pires G, McElligott S, Drusinsky S, Halliday G, Potier M, Wisniewski T, et al. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathol Commun. 2019;7:195 pubmed publisher
|
- immunohistochemistry - frozen section; human; 1:2000; loading ...; fig 7b
| Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, et al. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls. elife. 2019;8: pubmed publisher
|
- immunohistochemistry; mouse; 1:500; loading ...; fig s1
| Hansson O, Svensson M, Gustavsson A, Andersson E, Yang Y, Nagga K, et al. Midlife physical activity is associated with lower incidence of vascular dementia but not Alzheimer's disease. Alzheimers Res Ther. 2019;11:87 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:2500; loading ...; fig 4a
| Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 1a
| Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler R, Zhang S, et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model. Nat Neurosci. 2019;22:719-728 pubmed publisher
|
- western blot; mouse; loading ...; fig 3c
| Pan R, Ma J, Kong X, Wang X, Li S, Qi X, et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance. Sci Adv. 2019;5:eaau6328 pubmed publisher
|
- immunoprecipitation; human; loading ...; fig 1b
| Michno W, Nyström S, Wehrli P, Lashley T, Brinkmalm G, Guerard L, et al. Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology. J Biol Chem. 2019;294:6719-6732 pubmed publisher
|
- western blot; mouse; 1:11,000; loading ...; fig 3b
| Sri S, Pegasiou C, Cave C, Hough K, Wood N, Gomez Nicola D, et al. Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2019;7:25 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 4f
| Lahiri S, Regis G, Koronyo Y, Fuchs D, Sheyn J, Kim E, et al. Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice. Crit Care. 2019;23:63 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; loading ...; fig 2f
| Gerber H, Mosser S, Boury Jamot B, Stumpe M, Piersigilli A, Goepfert C, et al. The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta Neuropathol Commun. 2019;7:13 pubmed publisher
|
- immunohistochemistry; mouse; 1:300; loading ...; fig 2d
| Rosenzweig N, Dvir Szternfeld R, Tsitsou Kampeli A, Keren Shaul H, Ben Yehuda H, Weill Raynal P, et al. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model. Nat Commun. 2019;10:465 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3c
| Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
|
- western blot; human; loading ...; fig s3g
| Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisher
|
- flow cytometry; mouse; loading ...; fig 3b
- immunohistochemistry; mouse; loading ...; fig 3b
| Thygesen C, Ilkjær L, Kempf S, Hemdrup A, von Linstow C, Babcock A, et al. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. Front Cell Neurosci. 2018;12:397 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; loading ...; fig 2e
| Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson M. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiol Aging. 2018;70:160-169 pubmed publisher
|
- western blot; human; loading ...; fig 3a
| Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, et al. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Mol Psychiatry. 2018;: pubmed publisher
|
- immunohistochemistry - free floating section; mouse; loading ...; fig 1a
| Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6c
- western blot; mouse; 1:1000; loading ...; fig 8b
| Barbero Camps E, Roca Agujetas V, Bartolessis I, de Dios C, Fernandez Checa J, Mari M, et al. Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion. Autophagy. 2018;14:1129-1154 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig s1
| Wendeln A, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556:332-338 pubmed publisher
|
- western blot; mouse; 1:5000; loading ...; fig 1b
| Chiang A, Fowler S, Savjani R, Hilsenbeck S, Wallace C, Cirrito J, et al. Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med. 2018;215:1349-1364 pubmed publisher
|
- immunocytochemistry; mouse; loading ...; fig 3a
| Casali B, Reed Geaghan E, Landreth G. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease. J Neuroinflammation. 2018;15:43 pubmed publisher
|
- western blot; human; loading ...; fig 1a
| Mukadam A, Breusegem S, Seaman M. Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing. Cell Mol Life Sci. 2018;75:2613-2625 pubmed publisher
|
- immunohistochemistry - frozen section; African green monkey; 1:12,000; loading ...; fig 4a
| Cramer P, Gentzel R, Tanis K, Vardigan J, Wang Y, Connolly B, et al. Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease. Neurobiol Aging. 2018;64:92-106 pubmed publisher
|
- western blot; mouse; 1:2500; loading ...; fig 5a
| Chiang A, Fowler S, Reddy R, Pletnikova O, Troncoso J, Sherman M, et al. Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018;188:739-756 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:3000; loading ...; fig 1a
| Ziegler Waldkirch S, d Errico P, Sauer J, Erny D, Savanthrapadian S, Loreth D, et al. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease. EMBO J. 2018;37:167-182 pubmed publisher
|
- western blot; human; fig 2a
| Benvegnù S, Wahle T, Dotti C. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget. 2017;8:89439-89450 pubmed publisher
|
- immunocytochemistry; rat; 1:1000; loading ...; fig 7a
| Íñigo Marco I, Valencia M, Larrea L, Bugallo R, Martínez Goikoetxea M, Zuriguel I, et al. E46K ?-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation. Proc Natl Acad Sci U S A. 2017;114:E8274-E8283 pubmed publisher
|
- immunohistochemistry - frozen section; African green monkey; 1:7500; loading ...; fig 1a
| Edler M, Sherwood C, Meindl R, Hopkins W, Ely J, Erwin J, et al. Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease. Neurobiol Aging. 2017;59:107-120 pubmed publisher
|
- immunocytochemistry; human; 1:1000; loading ...; fig 6a
- western blot; human; loading ...; fig s1a
| Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher
|
- immunocytochemistry; mouse; loading ...; fig s5b
| Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher
|
- immunohistochemistry - paraffin section; human; loading ...; fig 2a
| Siedlak S, Jiang Y, Huntley M, Wang L, Gao J, Xie F, et al. TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease. J Alzheimers Dis. 2017;58:1027-1033 pubmed publisher
|
- western blot; human; 1:2000; loading ...; fig 4a
| Koistinen N, Edlund A, Menon P, Ivanova E, Bacanu S, Iverfeldt K. Nuclear localization of amyloid-? precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis. PLoS ONE. 2017;12:e0173888 pubmed publisher
|
- immunohistochemistry - free floating section; mouse; loading ...; fig 4j
| Gardenal E, Chiarini A, Armato U, Dal Pra I, Verkhratsky A, Rodriguez J. Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease. Front Neurosci. 2017;11:81 pubmed publisher
|
- immunohistochemistry; human; 1:1000; loading ...; fig 5a
| Zheng T, Pu J, Chen Y, Mao Y, Guo Z, Pan H, et al. Plasma Exosomes Spread and Cluster Around ?-Amyloid Plaques in an Animal Model of Alzheimer's Disease. Front Aging Neurosci. 2017;9:12 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 1e
| Mellott T, Huleatt O, Shade B, Pender S, Liu Y, Slack B, et al. Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS ONE. 2017;12:e0170450 pubmed publisher
|
- immunocytochemistry; human; 1:100; loading ...; fig 5b
| Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1d
- western blot; mouse; 1:1000; loading ...; fig 1f
| Yang S, Lee D, Shin J, Lee S, Baek S, Kim J, et al. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO Mol Med. 2017;9:61-77 pubmed publisher
|
- western blot; human; loading ...; fig 3b
| Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed publisher
|
- immunohistochemistry - paraffin section; rat; 1:100; fig 3
| Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed publisher
|
- western blot; mouse; fig 4
| Xu J, De Winter F, Farrokhi C, Rockenstein E, Mante M, Adame A, et al. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep. 2016;6:31692 pubmed publisher
|
- western blot; human; 1:2000; fig 2
| Marzesco A, Flötenmeyer M, Bühler A, Obermüller U, Staufenbiel M, Jucker M, et al. Highly potent intracellular membrane-associated A? seeds. Sci Rep. 2016;6:28125 pubmed publisher
|
- western blot; human; fig 1
| Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, et al. Deacetylation of TFEB promotes fibrillar A? degradation by upregulating lysosomal biogenesis in microglia. Protein Cell. 2016;7:417-33 pubmed publisher
|
- immunohistochemistry; mouse; 1:100; fig 3
- western blot; mouse; 1:1000; fig 3
| Lee K, Lee H, Lin H, Tsay H, Tsai F, Shyue S, et al. Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease. J Neuroinflammation. 2016;13:92 pubmed publisher
|
- western blot; fruit fly ; fig 1
| Ando K, Maruko Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima K. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity. PLoS Genet. 2016;12:e1005917 pubmed publisher
|
- immunoprecipitation; human; fig 4
| Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed publisher
|
- immunohistochemistry - free floating section; human; 1:1000; tbl 2
| Perez S, Sherwood C, Cranfield M, Erwin J, Mudakikwa A, Hof P, et al. Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol Aging. 2016;39:195-201 pubmed publisher
|
- immunohistochemistry; mouse; 1:100; fig 4
- western blot; mouse; 1:1000; fig 4
| Peng Y, Kim M, Hullinger R, O Riordan K, Burger C, Pehar M, et al. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain. 2016;139:937-52 pubmed publisher
|
- western blot; human; 1:1000; tbl 1
- western blot; mouse; 1:1000; tbl 1
| Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
|
- western blot; hamsters; fig 7
| Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
|
- western blot; fruit fly ; 1:2000; fig 2O
| Lee S, Bang S, Hong Y, Lee J, Jeong H, Park S, et al. The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease. Dis Model Mech. 2016;9:295-306 pubmed publisher
|
- western blot; mouse; fig s5
| De Mario A, Castellani A, Peggion C, Massimino M, Lim D, Hill A, et al. The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase. Front Cell Neurosci. 2015;9:416 pubmed publisher
|
- western blot; human; 1:1500; fig 3
- western blot; mouse; 1:1500; fig 3
| Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed publisher
|
- western blot; mouse; 1:2000; fig 5e
| Ostapchenko V, Chen M, Guzman M, Xie Y, Lavine N, Fan J, et al. The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J Neurosci. 2015;35:15157-69 pubmed publisher
|
- immunohistochemistry; mouse; 1:500; fig 4
| Sabogal Guáqueta A, Osorio E, Cardona Gómez G. Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice. Neuropharmacology. 2016;102:111-20 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:1000; fig 1
| Cherry J, Olschowka J, O Banion M. Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation. J Neuroinflammation. 2015;12:203 pubmed publisher
|
- western blot; human; 1:1000
| Kumar R, Nordberg A, Darreh Shori T. Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs. Brain. 2016;139:174-92 pubmed publisher
|
- ELISA; human; 2 ug/ml; fig 6
| Miners J, Palmer J, Love S. Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease. Brain Pathol. 2016;26:533-41 pubmed publisher
|
- western blot; mouse; loading ...; fig 6a
| Kokiko Cochran O, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, et al. Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Neurotrauma. 2016;33:625-40 pubmed publisher
|
- immunohistochemistry; human; tbl 1
| Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher
|
| Nevzglyadova O, Mikhailova E, Amen T, Zenin V, Artemov A, Kostyleva E, et al. Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster. Amyloid. 2015;22:100-11 pubmed publisher
|
- other; human; 1:100; loading ...; fig 2a
| Cuddy L, Seah C, Pasternak S, Rylett R. Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein. J Neurochem. 2015;134:769-82 pubmed publisher
|
- western blot; mouse; 1:2500
| Liu P, Paulson J, Forster C, Shapiro S, Ashe K, Zahs K. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS ONE. 2015;10:e0126317 pubmed publisher
|
- immunoprecipitation; human
| Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed publisher
|
- immunohistochemistry; mouse; 1:500
| Yetman M, Lillehaug S, Bjaalie J, Leergaard T, Jankowsky J. Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex. Brain Struct Funct. 2016;221:2231-49 pubmed publisher
|
- western blot; mouse; 1:2000
| Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed publisher
|
| Jay T, Miller C, Cheng P, Graham L, Bemiller S, Broihier M, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015;212:287-95 pubmed publisher
|
- western blot; mouse; loading ...; fig 6e
| Woo J, Zhao X, Khan H, Penn C, Wang X, Joly Amado A, et al. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death Differ. 2015;22:921-34 pubmed publisher
|
- immunohistochemistry; mouse; 1:500
| Sabogal Guáqueta A, Muñoz Manco J, RamÃrez Pineda J, Lamprea Rodriguez M, Osorio E, Cardona Gómez G. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. Neuropharmacology. 2015;93:134-45 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:600
| Wu Z, Yang B, Liu C, Liang G, Eckenhoff M, Liu W, et al. Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer Dis Assoc Disord. 2015;29:184-191 pubmed publisher
|
| Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed publisher
|
- immunohistochemistry; rat
- western blot; rat; 1:1000
| Kang E, Cho J. Effects of treadmill exercise on brain insulin signaling and β-amyloid in intracerebroventricular streptozotocin induced-memory impairment in rats. J Exerc Nutrition Biochem. 2014;18:89-96 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:300
- ELISA; human; 1:1000
| Ashby E, Miners J, Kumar S, Walter J, Love S, Kehoe P. Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia. Neuropathol Appl Neurobiol. 2015;41:428-44 pubmed publisher
|
- western blot; human; 1:1000
| Vingtdeux V, Tanis J, Chandakkar P, Zhao H, Dreses Werringloer U, Campagne F, et al. Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels. PLoS ONE. 2014;9:e112484 pubmed publisher
|
- western blot; human; 1:2000
| Thomzig A, Wagenführ K, Daus M, Joncic M, Schulz Schaeffer W, Thanheiser M, et al. Decontamination of medical devices from pathological amyloid-?-, tau- and ?-synuclein aggregates. Acta Neuropathol Commun. 2014;2:151 pubmed publisher
|
- immunocytochemistry; mouse; 1:1000
- western blot; mouse; 1:1000
| Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed publisher
|
- immunocytochemistry; human
- ELISA; human
- western blot; human
| Maloney J, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, et al. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. J Biol Chem. 2014;289:30990-1000 pubmed publisher
|
- immunohistochemistry - free floating section; human; 1:2500
- western blot; human; 1:2500
| Lue L, Schmitz C, Serrano G, Sue L, Beach T, Walker D. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices. Brain Pathol. 2015;25:469-80 pubmed publisher
|
- immunocytochemistry; mouse
| Dunn H, Ager R, Baglietto Vargas D, Cheng D, Kitazawa M, Cribbs D, et al. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015;43:893-903 pubmed publisher
|
| Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, et al. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. J Biol Chem. 2014;289:27080-9 pubmed publisher
|
- immunocytochemistry; human; 1:50
| Kohler C, Dinekov M, Götz J. Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and A? amyloidosis. Neurobiol Dis. 2014;71:169-79 pubmed publisher
|
| Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger J, Zerbinatti C. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE. 2014;9:e103187 pubmed publisher
|
- western blot; human; 1:5000
| Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher
|
- western blot; mouse; 1:2500
| Fowler S, Chiang A, Savjani R, Larson M, Sherman M, Schuler D, et al. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014;34:7871-85 pubmed publisher
|
- western blot; mouse; 1:500
| Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher
|
- immunohistochemistry - paraffin section; human; 1:300
| Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
|
- immunoprecipitation; human
- western blot; human; 1:1000
| Pujadas L, Rossi D, Andres R, Teixeira C, Serra Vidal B, Parcerisas A, et al. Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease. Nat Commun. 2014;5:3443 pubmed publisher
|
- immunohistochemistry; human; 1 ug/ml
| Xiong Z, Thangavel R, Kempuraj D, Yang E, Zaheer S, Zaheer A. Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain. J Alzheimers Dis. 2014;40:297-308 pubmed publisher
|
- western blot; human; 1:1000
| Bana L, Minniti S, Salvati E, Sesana S, Zambelli V, Cagnotto A, et al. Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A? aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease. Nanomedicine. 2014;10:1583-90 pubmed publisher
|
- immunohistochemistry - free floating section; mouse
- western blot; mouse
| Medeiros R, Castello N, Cheng D, Kitazawa M, Baglietto Vargas D, Green K, et al. ?7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014;184:520-9 pubmed publisher
|
| El Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell. 2014;13:165-74 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:1500
| ElAli A, Theriault P, Prefontaine P, Rivest S. Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation. Acta Neuropathol Commun. 2013;1:75 pubmed publisher
|
- immunohistochemistry - free floating section; mouse; 1:2000
| Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, et al. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014;39:191-210 pubmed publisher
|
- western blot; mouse; 1:1000
| Washington P, Morffy N, Parsadanian M, Zapple D, Burns M. Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model. J Neurotrauma. 2014;31:125-34 pubmed publisher
|
- western blot; human; 1:1000
| Li W, Tang Y, Fan Z, Meng Y, Yang G, Luo J, et al. Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide. Mol Neurodegener. 2013;8:27 pubmed publisher
|
- immunohistochemistry - paraffin section; mouse; 1:300
- western blot; mouse; 1:1000
| Kang E, Kwon I, Koo J, Kim E, Kim C, Lee J, et al. Treadmill exercise represses neuronal cell death and inflammation during A?-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis. 2013;18:1332-1347 pubmed publisher
|
- immunohistochemistry; mouse; 1:200
| Devi L, Ohno M. Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry. 2013;3:e284 pubmed publisher
|
- immunohistochemistry - frozen section; mouse
| Manich G, del Valle J, Cabezón I, Camins A, Pallas M, Pelegri C, et al. Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice. Age (Dordr). 2014;36:151-65 pubmed publisher
|
- immunohistochemistry; human
| Jackson K, Barisone G, Diaz E, Jin L, DeCarli C, Despa F. Amylin deposition in the brain: A second amyloid in Alzheimer disease?. Ann Neurol. 2013;74:517-26 pubmed publisher
|
- immunohistochemistry - frozen section; human; 2 ug/ml
| Brana C, Frossard M, Pescini Gobert R, Martinier N, Boschert U, Seabrook T. Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions. Neuropathol Appl Neurobiol. 2014;40:564-78 pubmed publisher
|
- immunohistochemistry; mouse; 1:200
| Choi J, Kaur G, Mazzella M, Morales Corraliza J, Levy E, Mathews P. Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-? protein precursor transgenic mice. J Alzheimers Dis. 2013;34:691-700 pubmed publisher
|
| Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed publisher
|
| Beyer A, von Einem B, Schwanzar D, Keller I, Hellrung A, Thal D, et al. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-? precursor protein. Neurobiol Aging. 2012;33:732-43 pubmed publisher
|
| Hao X, Li Z, Li W, Katz J, Michalek S, Barnum S, et al. Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice. Front Immunol. 2022;13:816640 pubmed publisher
|
| Li L, Li J, Dai Y, Yang M, Liang S, Wang Z, et al. Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease Mice via Basal Forebrain-Hippocampus Cholinergic Neural Circuit. Front Aging Neurosci. 2021;13:770948 pubmed publisher
|
| Hung C, Tuck E, Stubbs V, van der Lee S, Aalfs C, van Spaendonk R, et al. SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network. Cell Rep. 2021;35:109259 pubmed publisher
|
| Hsu C, Chang C, Poopradubsil T, Lo A, William K, Lin K, et al. Antibody Watch: Text mining antibody specificity from the literature. PLoS Comput Biol. 2021;17:e1008967 pubmed publisher
|
| Martin L, Bouvet P, Chounlamountri N, Watrin C, Besancon R, Pinatel D, et al. VEGF counteracts amyloid-β-induced synaptic dysfunction. Cell Rep. 2021;35:109121 pubmed publisher
|
| Bourdenx M, Martín Segura A, Scrivo A, Rodriguez Navarro J, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696-2714.e25 pubmed publisher
|
| Colombo A, Sadler R, Llovera G, Singh V, Roth S, Heindl S, et al. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. elife. 2021;10: pubmed publisher
|
| La Barbera L, Vedele F, Nobili A, Krashia P, Spoleti E, Latagliata E, et al. Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease. Prog Neurobiol. 2021;202:102031 pubmed publisher
|
| Guo X, Liu Y, Morgan D, Zhao L. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging Dis. 2020;11:1423-1443 pubmed publisher
|
| Leal N, Dentoni G, Schreiner B, Naia L, Piras A, Graff C, et al. Amyloid Β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer's Disease-Related Models. Cells. 2020;9: pubmed publisher
|
| Cho Y, Kwon O, Chung S. Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains. Molecules. 2020;25: pubmed publisher
|
| Cen X, Chen Y, Xu X, Wu R, He F, Zhao Q, et al. Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model. Nat Commun. 2020;11:5731 pubmed publisher
|
| Jeon S, Kim N, Ju Y, Gee M, Lee D, Lee J. Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2. Int J Mol Sci. 2020;21: pubmed publisher
|
| Doustar J, Rentsendorj A, Torbati T, Regis G, Fuchs D, Sheyn J, et al. Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models. Aging Cell. 2020;:e13246 pubmed publisher
|
| Montalbano M, McAllen S, Cascio F, Sengupta U, Garcia S, Bhatt N, et al. TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Neurobiol Dis. 2020;146:105130 pubmed publisher
|
| Huang L, McClatchy D, Maher P, Liang Z, Diedrich J, Soriano Castell D, et al. Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death. Cell Death Dis. 2020;11:828 pubmed publisher
|
| Farid M, Yang X, Kuboyama T, Tohda C. Trigonelline recovers memory function in Alzheimer's disease model mice: evidence of brain penetration and target molecule. Sci Rep. 2020;10:16424 pubmed publisher
|
| Mo D, Li X, Raabe C, Rozhdestvensky T, Skryabin B, Brosius J. Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. Cells. 2020;9: pubmed publisher
|
| Lee Y, Choi Y, Park E, Kwon S, Kim H, Lee J, et al. Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer's disease model. Sci Rep. 2020;10:16144 pubmed publisher
|
| Yao J, Sun B, Institoris A, Zhan X, Guo W, Song Z, et al. Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation. Cell Rep. 2020;32:108169 pubmed publisher
|
| Shippy D, Wilhelm C, Viharkumar P, Raife T, Ulland T. β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology. J Neuroinflammation. 2020;17:280 pubmed publisher
|
| Li L, Li L, Zhang J, Huang S, Liu W, Wang Z, et al. Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer's Disease. Neural Plast. 2020;2020:8836173 pubmed publisher
|
| von Saucken V, Jay T, Landreth G. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiol Dis. 2020;145:105072 pubmed publisher
|
| Liu D, Zhao Y, Qi Y, Gao Y, Tu D, Wang Y, et al. Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice. J Neuroinflammation. 2020;17:258 pubmed publisher
|
| Pérez González R, Kim Y, Miller C, Pacheco Quinto J, Eckman E, Levy E. Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes. FASEB J. 2020;34:12922-12931 pubmed publisher
|
| Ikonomovic M, Buckley C, Abrahamson E, Kofler J, Mathis C, Klunk W, et al. Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer's disease. Acta Neuropathol. 2020;140:463-476 pubmed publisher
|
| Chen W, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, et al. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. Cell. 2020;182:976-991.e19 pubmed publisher
|
| Neddens J, Daurer M, Flunkert S, Beutl K, Loeffler T, Walker L, et al. Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models. PLoS ONE. 2020;15:e0235543 pubmed publisher
|
| Shi Y, Zhang L, Gao X, Zhang J, Ben Abou M, Liang G, et al. Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice. J Alzheimers Dis. 2020;76:1375-1389 pubmed publisher
|
| Ren J, Zhang S, Wang X, Guan Z, Qi X. Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells. Mol Med Rep. 2020;22:2063-2075 pubmed publisher
|
| Socodato R, Portugal C, Canedo T, Rodrigues A, Almeida T, Henriques J, et al. Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell Rep. 2020;31:107796 pubmed publisher
|
| Zhang H, Chen W, Tan Z, Zhang L, Dong Z, Cui W, et al. A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Aβ Clearance. J Neurosci. 2020;40:5347-5361 pubmed publisher
|
| Maron R, Armony G, Tsoory M, Wilchek M, Frenkel D, Arnon R. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. Int J Mol Sci. 2020;21: pubmed publisher
|
| Calvo Rodríguez M, Hou S, Snyder A, Kharitonova E, Russ A, Das S, et al. Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nat Commun. 2020;11:2146 pubmed publisher
|
| Gee M, Son S, Jeon S, Do J, Kim N, Ju Y, et al. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimers Res Ther. 2020;12:45 pubmed publisher
|
| Tambini M, D ADAMIO L. Knock-in rats with homozygous PSEN1L435F Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43. J Biol Chem. 2020;295:7442-7451 pubmed publisher
|
| Brozzetti L, Sacchetto L, Cecchini M, Avesani A, Perra D, Bongianni M, et al. Neurodegeneration-Associated Proteins in Human Olfactory Neurons Collected by Nasal Brushing. Front Neurosci. 2020;14:145 pubmed publisher
|
| An Y, Zhang H, Huang S, Pei G. PL201, a Reported Rhamnoside Against Alzheimer's Disease Pathology, Alleviates Neuroinflammation and Stimulates Nrf2 Signaling. Front Immunol. 2020;11:162 pubmed publisher
|
| Li S, Hayden E, Garcia V, Fuchs D, Sheyn J, Daley D, et al. Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses. Front Immunol. 2020;11:49 pubmed publisher
|
| Chen X, Ji B, Hao X, Li X, Eisele F, Nystrom T, et al. FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism. Nat Commun. 2020;11:867 pubmed publisher
|
| Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed publisher
|
| Reed Geaghan E, Croxford A, Becher B, Landreth G. Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model. J Exp Med. 2020;217: pubmed publisher
|
| Bai B, Wang X, Li Y, Chen P, Yu K, Dey K, et al. Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression. Neuron. 2020;105:975-991.e7 pubmed publisher
|
| Hu T, Zhou Y, Lu J, Xia P, Chen Y, Cao X, et al. A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer's-like pathology. Aging (Albany NY). 2020;12:481-501 pubmed publisher
|
| Koronyo Hamaoui M, Sheyn J, Hayden E, Li S, Fuchs D, Regis G, et al. Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease. Brain. 2020;143:336-358 pubmed publisher
|
| Michno W, Wehrli P, Meier S, Sehlin D, Syvänen S, Zetterberg H, et al. Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease. J Neurochem. 2020;152:602-616 pubmed publisher
|
| Fiock K, Smith J, Crary J, Hefti M. β-amyloid and tau pathology in the aging feline brain. J Comp Neurol. 2020;528:108-113 pubmed publisher
|
| Ren J, Wang X, Gao Y, Wang F, Guan Z, Qi X. The expression of the nicotinic acetylcholine receptor α3 subunit in the brains of patients with Alzheimer's disease and its effects on α- and γ-secretases and Notch signal transduction in SH-SY5Y cells. Int J Clin Exp Pathol. 2019;12:3644-3652 pubmed
|
| Wang S, Jiang W, Ouyang T, Shen X, Wang F, Qu Y, et al. Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice. Sci Rep. 2019;9:19575 pubmed publisher
|
| Medina C, Uselman T, Barto D, Chaves F, Jacobs R, Bearer E. Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain. Front Cell Neurosci. 2019;13:501 pubmed publisher
|
| Lee H, Lee K, Chen C, Lee T. Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019;16:267 pubmed publisher
|
| Beraldo F, Palmer D, Memar S, Wasserman D, Lee W, Liang S, et al. MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment. elife. 2019;8: pubmed publisher
|
| Cox L, Schafer M, Sohn J, Vincentini J, Weiner H, Ginsberg S, et al. Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice. Sci Rep. 2019;9:17904 pubmed publisher
|
| Ding Y, Zhao J, Zhang X, Wang S, Viola K, Chow F, et al. Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease. Front Neurol. 2019;10:1140 pubmed publisher
|
| Kollmer M, Close W, Funk L, Rasmussen J, Bsoul A, Schierhorn A, et al. Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun. 2019;10:4760 pubmed publisher
|
| Griner S, Seidler P, Bowler J, Murray K, Yang T, Sahay S, et al. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. elife. 2019;8: pubmed publisher
|
| van Husen L, Schedin Weiss S, Trung M, Kazmi M, Winblad B, Sakmar T, et al. Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products. J Alzheimers Dis. 2019;72:537-548 pubmed publisher
|
| Zysk M, Clausen F, Aguilar X, Sehlin D, Syvänen S, Erlandsson A. Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2019;72:161-180 pubmed publisher
|
| Bonds J, Shetti A, Bheri A, Chen Z, Disouky A, Tai L, et al. Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors. J Neurosci. 2019;39:8576-8583 pubmed publisher
|
| Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019;29:787-803 pubmed publisher
|
| Shmueli M, Hizkiahou N, Peled S, Gazit E, Segal D. Total proteome turbidity assay for tracking global protein aggregation in the natural cellular environment. J Biol Methods. 2017;4:e69 pubmed publisher
|
| Esposito G, Mai L, Longeon A, Mangoni A, Durieu E, Meijer L, et al. A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens. Mar Drugs. 2019;17: pubmed publisher
|
| SPANGENBERG E, Severson P, Hohsfield L, Crapser J, Zhang J, Burton E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019;10:3758 pubmed publisher
|
| de Dios C, Bartolessis I, Roca Agujetas V, Barbero Camps E, Mari M, Morales A, et al. Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress. Redox Biol. 2019;26:101283 pubmed publisher
|
| Imanikia S, Sheng M, Castro C, Griffin J, Taylor R. XBP-1 Remodels Lipid Metabolism to Extend Longevity. Cell Rep. 2019;28:581-589.e4 pubmed publisher
|
| Li L, Roh J, Kim H, Park H, Kim M, Koh W, et al. The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction. Exp Neurobiol. 2019;28:329-336 pubmed publisher
|
| Imanikia S, Özbey N, Krueger C, Casanueva M, Taylor R. Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans. Curr Biol. 2019;29:2322-2338.e7 pubmed publisher
|
| Chandra S, Pahan K. Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer's Disease via Peroxisome Proliferator-Activated Receptor α. J Alzheimers Dis Rep. 2019;3:149-168 pubmed publisher
|
| Baik S, Kang S, Lee W, Choi H, Chung S, Kim J, et al. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell Metab. 2019;30:493-507.e6 pubmed publisher
|
| Harper M, Hedberg Buenz A, Herlein J, Abrahamson E, Anderson M, Kuehn M, et al. Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci. 2019;60:2716-2725 pubmed publisher
|
| Paula P, Angelica Maria S, Luis C, Gloria Patricia C. Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model. Molecules. 2019;24: pubmed publisher
|
| Sheng L, Chen M, Cai K, Song Y, Yu D, Zhang H, et al. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. FASEB J. 2019;33:10425-10442 pubmed publisher
|
| Qin K, Zhao L, Gregory C, Solanki A, Mastrianni J. "Dual Disease" TgAD/GSS mice exhibit enhanced Alzheimer's disease pathology and reveal PrPC-dependent secretion of Aβ. Sci Rep. 2019;9:8524 pubmed publisher
|
| Prakash P, Lantz T, Jethava K, Chopra G. Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid beta 1-42. Methods Protoc. 2019;2: pubmed publisher
|
| Esquerda Canals G, Martí Clúa J, Villegas S. Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment. PLoS ONE. 2019;14:e0217793 pubmed publisher
|
| Gulisano W, Melone M, Ripoli C, Rosaria Tropea M, Li Puma D, Giunta S, et al. Neuromodulatory action of picomolar extracellular Aβ42 oligomers on pre- and postsynaptic mechanisms underlying synaptic function and memory. J Neurosci. 2019;: pubmed publisher
|
| Braggin J, Bucks S, Course M, Smith C, Sopher B, Osnis L, et al. Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Ann Clin Transl Neurol. 2019;6:762-777 pubmed publisher
|
| Grant M, Shapiro S, Ashe K, Liu P, Zahs K. A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 2019;21:6 pubmed publisher
|
| Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Rep. 2019;27:1293-1306.e6 pubmed publisher
|
| Dyer M, Phipps A, Mitew S, Taberlay P, Woodhouse A. Age, but Not Amyloidosis, Induced Changes in Global Levels of Histone Modifications in Susceptible and Disease-Resistant Neurons in Alzheimer's Disease Model Mice. Front Aging Neurosci. 2019;11:68 pubmed publisher
|
| Cecon E, Dam J, Luka M, Gautier C, Chollet A, Delagrange P, et al. Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor. Br J Pharmacol. 2019;176:3475-3488 pubmed publisher
|
| Fowler A, Hebron M, Missner A, Wang R, Gao X, Kurd Misto B, et al. Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration. Drugs R D. 2019;19:149-166 pubmed publisher
|
| Leonetti M, Grimaldi A, Ghirga S, Ruocco G, Antonacci G. Scattering Assisted Imaging. Sci Rep. 2019;9:4591 pubmed publisher
|
| Yang P, Guo Y, Sun Y, Yu B, Zhang H, Wu J, et al. Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice. BMC Immunol. 2019;20:9 pubmed publisher
|
| Huichalaf C, Al Ramahi I, Park K, Grunke S, Lu N, de Haro M, et al. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Hum Mol Genet. 2019;28:2014-2029 pubmed publisher
|
| Fang E, Hou Y, Palikaras K, Adriaanse B, Kerr J, Yang B, et al. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci. 2019;22:401-412 pubmed publisher
|
| Merlini M, Rafalski V, Rios Coronado P, Gill T, Ellisman M, Muthukumar G, et al. Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Neuron. 2019;101:1099-1108.e6 pubmed publisher
|
| Stimmell A, Baglietto Vargas D, Moseley S, Lapointe V, Thompson L, LaFerla F, et al. Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease. Sci Rep. 2019;9:1311 pubmed publisher
|
| Zheng Y, Liu A, Wang Z, Cao Q, Wang W, Lin L, et al. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease. Brain. 2019;142:787-807 pubmed publisher
|
| Limbocker R, Chia S, Ruggeri F, Perni M, Cascella R, Heller G, et al. Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nat Commun. 2019;10:225 pubmed publisher
|
| Hung C, Livesey F. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease. Cell Rep. 2018;25:3647-3660.e2 pubmed publisher
|
| Keene C, Wilson A, Kilgore M, Bruner L, Postupna N, Darvas M. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest. 2018;: pubmed publisher
|
| Cline E, Das A, Bicca M, Mohammad S, Schachner L, Kamel J, et al. A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies. J Neurochem. 2019;148:822-836 pubmed publisher
|
| Dolfe L, Tambaro S, Tigro H, Del Campo M, Hoozemans J, Wiehager B, et al. The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques. J Alzheimers Dis Rep. 2018;2:27-39 pubmed publisher
|
| Rosenberg R, Fu M, Lambracht Washington D. Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology. Alzheimers Res Ther. 2018;10:115 pubmed publisher
|
| Bartolotti N, Disouky A, Kalinski A, Elmann A, Lazarov O. Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism. J Alzheimers Dis. 2018;66:1425-1435 pubmed publisher
|
| Barykin E, Petrushanko I, Kozin S, Telegin G, CHERNOV A, Lopina O, et al. Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition. Front Mol Neurosci. 2018;11:302 pubmed publisher
|
| Kozin S, Barykin E, Telegin G, CHERNOV A, Adzhubei A, Radko S, et al. Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer's Disease. Front Neurosci. 2018;12:518 pubmed publisher
|
| Ahmad F, Das D, Kommaddi R, Diwakar L, Gowaikar R, Rupanagudi K, et al. Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. Sci Rep. 2018;8:13119 pubmed publisher
|
| Gonzalez C, Armijo E, Bravo Alegria J, Becerra Calixto A, Mays C, Soto C. Modeling amyloid beta and tau pathology in human cerebral organoids. Mol Psychiatry. 2018;23:2363-2374 pubmed publisher
|
| Rubio Araiz A, Finucane O, Keogh S, Lynch M. Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid. J Neuroinflammation. 2018;15:247 pubmed publisher
|
| Khan I, Krishnaswamy S, Sabale M, Groth D, Wijaya L, Morici M, et al. Efficient production of a mature and functional gamma secretase protease. Sci Rep. 2018;8:12834 pubmed publisher
|
| Edler M, Sherwood C, Meindl R, Munger E, Hopkins W, Ely J, et al. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. J Comp Neurol. 2018;526:2921-2936 pubmed publisher
|
| Bearer E, Manifold Wheeler B, Medina C, Gonzales A, Chaves F, Jacobs R. Alterations of functional circuitry in aging brain and the impact of mutated APP expression. Neurobiol Aging. 2018;70:276-290 pubmed publisher
|
| Goodman J, Adham Z, Woltjer R, Lund A, Iliff J. Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects. Brain Behav Immun. 2018;73:34-40 pubmed publisher
|
| Wang D, Zhang X, Wang M, Zhou D, Pan H, Shu Q, et al. Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer's Disease. Neurosci Bull. 2018;34:912-920 pubmed publisher
|
| Chernick D, Ortiz Valle S, Jeong A, Swaminathan S, Kandimalla K, Rebeck G, et al. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. J Neurochem. 2018;147:647-662 pubmed publisher
|
| Herzer S, Hagan C, von Gerichten J, Dieterle V, Munteanu B, Sandhoff R, et al. Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer's Disease. Front Mol Neurosci. 2018;11:206 pubmed publisher
|
| Chandra S, Jana M, Pahan K. Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα. J Neurosci. 2018;38:6682-6699 pubmed publisher
|
| Roitenberg N, Bejerano Sagie M, Boocholez H, Moll L, Marques F, Golodetzki L, et al. Modulation of caveolae by insulin/IGF-1 signaling regulates aging of Caenorhabditis elegans. EMBO Rep. 2018;19: pubmed publisher
|
| Readhead B, Haure Mirande J, Funk C, Richards M, Shannon P, Haroutunian V, et al. Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron. 2018;99:64-82.e7 pubmed publisher
|
| Opazo P, Viana da Silva S, Carta M, Breillat C, Coultrap S, Grillo Bosch D, et al. CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity. Cell Rep. 2018;23:3137-3145 pubmed publisher
|
| Spitzer P, Lang R, Oberstein T, Lewczuk P, Ermann N, Huttner H, et al. A Specific Reduction in Aβ1-42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis. Front Aging Neurosci. 2018;10:152 pubmed publisher
|
| Dong Z, Li J, Gan Y, Sun X, Leng Y, Ge J. Amyloid beta deposition related retinal pigment epithelium cell impairment and subretinal microglia activation in aged APPswePS1 transgenic mice. Int J Ophthalmol. 2018;11:747-755 pubmed publisher
|
| Zhang J, Yu L, Yang H, Hui Z, Jiang S, Chen L, et al. Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing A? deposition. BMC Complement Altern Med. 2018;18:167 pubmed publisher
|
| Vargas Restrepo F, Sabogal Guáqueta A, Cardona Gómez G. [Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]. Biomedica. 2018;38:69-76 pubmed publisher
|
| Serra Batiste M, Tolchard J, Giusti F, Zoonens M, Carulla N. Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease. Front Mol Biosci. 2018;5:38 pubmed publisher
|
| Van der Jeugd A, Parra Damas A, Baeta Corral R, Soto Faguás C, Ahmed T, LaFerla F, et al. Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice. Sci Rep. 2018;8:6431 pubmed publisher
|
| Jonson M, Nyström S, Sandberg A, Carlback M, Michno W, Hanrieder J, et al. Aggregated Aβ1-42 Is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila. Cell Chem Biol. 2018;25:595-610.e5 pubmed publisher
|
| Söllvander S, Nikitidou E, Gallasch L, Zysk M, Söderberg L, Sehlin D, et al. The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death. J Neuroinflammation. 2018;15:98 pubmed publisher
|
| Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Yokoyama I, et al. Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice. J Neuroimmunol. 2018;319:80-92 pubmed publisher
|
| Yan T, Wang L, Gao J, Siedlak S, Huntley M, Termsarasab P, et al. Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease. J Alzheimers Dis. 2018;63:157-165 pubmed publisher
|
| Datta M, Staszewski O, Raschi E, Frosch M, Hagemeyer N, Tay T, et al. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. 2018;48:514-529.e6 pubmed publisher
|
| Sachdev R, Kappes Horn K, Paulsen L, Duernberger Y, Pleschka C, Denner P, et al. Endoplasmic Reticulum Stress Induces Myostatin High Molecular Weight Aggregates and Impairs Mature Myostatin Secretion. Mol Neurobiol. 2018;55:8355-8373 pubmed publisher
|
| Song M, Song K, Kim S, Lee J, Hwang S, Han C. Caenorhabditis elegans BRICHOS Domain-Containing Protein C09F5.1 Maintains Thermotolerance and Decreases Cytotoxicity of Aβ42 by Activating the UPR. Genes (Basel). 2018;9: pubmed publisher
|
| Matthes F, Hettich M, Schilling J, Flores Dominguez D, Blank N, Wiglenda T, et al. Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis. Cell Death Discov. 2018;4:4 pubmed publisher
|
| Turnbull M, Boskovic Z, Coulson E. Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion. Front Mol Neurosci. 2018;11:51 pubmed publisher
|
| Zhang L, Trushin S, Christensen T, Tripathi U, Hong C, Geroux R, et al. Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane. Neurobiol Dis. 2018;114:1-16 pubmed publisher
|
| di Fede G, Catania M, Maderna E, Ghidoni R, Benussi L, Tonoli E, et al. Molecular subtypes of Alzheimer's disease. Sci Rep. 2018;8:3269 pubmed publisher
|
| Batarseh Y, Kaddoumi A. Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease. J Nutr Biochem. 2018;55:113-123 pubmed publisher
|
| Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, et al. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 2018;13:6 pubmed publisher
|
| Park J, Kim H, Lee J, Park J, Kim J, Hwang K, et al. Amyloid Beta Detection by Faradaic Electrochemical Impedance Spectroscopy Using Interdigitated Microelectrodes. Sensors (Basel). 2018;18: pubmed publisher
|
| Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, et al. Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep. 2018;8:1329 pubmed publisher
|
| Chandramowlishwaran P, Sun M, Casey K, Romanyuk A, Grizel A, Sopova J, et al. Mammalian amyloidogenic proteins promote prion nucleation in yeast. J Biol Chem. 2018;293:3436-3450 pubmed publisher
|
| Lim C, Han J. The antioxidant xanthorrhizol prevents amyloid-?-induced oxidative modification and inactivation of neprilysin. Biosci Rep. 2018;38: pubmed publisher
|
| Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, et al. Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations. J Neuropathol Exp Neurol. 2018;77:128-138 pubmed publisher
|
| Asam K, Staniszewski A, Zhang H, Melideo S, Mazzeo A, Voronkov M, et al. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. PLoS ONE. 2017;12:e0189413 pubmed publisher
|
| Welty S, Teng Y, Liang Z, Zhao W, Sanders L, Greenamyre J, et al. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem. 2018;293:1353-1362 pubmed publisher
|
| Huynh T, Liao F, Francis C, Robinson G, Serrano J, Jiang H, et al. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron. 2017;96:1013-1023.e4 pubmed publisher
|
| Buccarello L, Sclip A, Sacchi M, Castaldo A, Bertani I, ReCecconi A, et al. The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies. Oncotarget. 2017;8:83038-83051 pubmed publisher
|
| Chaney A, Bauer M, Bochicchio D, Smigova A, Kassiou M, Davies K, et al. Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe ×PS1?e9 transgenic mouse model of Alzheimer's disease. J Neurochem. 2017;: pubmed publisher
|
| Park J, Kwon J, Kim N, Song K. Effects of 1950 MHz radiofrequency electromagnetic fields on A? processing in human neuroblastoma and mouse hippocampal neuronal cells. J Radiat Res. 2017;:1-9 pubmed publisher
|
| Pera M, Larrea D, Guardia Laguarta C, Montesinos J, Velasco K, Agrawal R, et al. Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. EMBO J. 2017;36:3356-3371 pubmed publisher
|
| Yang C, Cai C, Song J, Tan J, Durairajan S, Iyaswamy A, et al. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 2017;13:2028-2040 pubmed publisher
|
| Chen L, Li G, Li Y, Li Y, Zhu H, Tang L, et al. UbasM: An effective balanced optical clearing method for intact biomedical imaging. Sci Rep. 2017;7:12218 pubmed publisher
|
| O Reilly M, Jones R, Barrett E, Schwab A, Head E, Hynynen K. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017;7:3573-3584 pubmed publisher
|
| Zhi D, Wang D, Yang W, Duan Z, Zhu S, Dong J, et al. Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans. Sci Rep. 2017;7:11408 pubmed publisher
|
| Colvin B, Rogers V, Kulas J, Ridgway E, Amtashar F, Combs C, et al. The conformational epitope for a new A?42 protofibril-selective antibody partially overlaps with the peptide N-terminal region. J Neurochem. 2017;143:736-749 pubmed publisher
|
| Yadav D, Maloney J, Wildsmith K, Fuji R, Meilandt W, Solanoy H, et al. Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates. Br J Pharmacol. 2017;174:4173-4185 pubmed publisher
|
| Bove Fenderson E, Urano R, Straub J, Harris D. Cellular prion protein targets amyloid-? fibril ends via its C-terminal domain to prevent elongation. J Biol Chem. 2017;292:16858-16871 pubmed publisher
|
| Willén K, Edgar J, Hasegawa T, Tanaka N, Futter C, Gouras G. A? accumulation causes MVB enlargement and is modelled by dominant negative VPS4A. Mol Neurodegener. 2017;12:61 pubmed publisher
|
| Sogorb Esteve A, García Ayllón M, Llansola M, Felipo V, Blennow K, Saez Valero J. Inhibition of γ-Secretase Leads to an Increase in Presenilin-1. Mol Neurobiol. 2018;55:5047-5058 pubmed publisher
|
| Zhu X, Wang S, Yu L, Jin J, Ye X, Liu Y, et al. HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease. Aging Cell. 2017;16:1073-1082 pubmed publisher
|
| Li N, Hu P, Xu T, Chen H, Chen X, Hu J, et al. iTRAQ-based Proteomic Analysis of APPSw,Ind Mice Provides Insights into the Early Changes in Alzheimer's Disease. Curr Alzheimer Res. 2017;14:1109-1122 pubmed publisher
|
| Kulas J, Puig K, Combs C. Amyloid precursor protein in pancreatic islets. J Endocrinol. 2017;235:49-67 pubmed publisher
|
| Plá V, Barranco N, Pozas E, Aguado F. Amyloid-β Impairs Vesicular Secretion in Neuronal and Astrocyte Peptidergic Transmission. Front Mol Neurosci. 2017;10:202 pubmed publisher
|
| Kedia N, Almisry M, Bieschke J. Glucose directs amyloid-beta into membrane-active oligomers. Phys Chem Chem Phys. 2017;19:18036-18046 pubmed publisher
|
| Sebollela A, Cline E, Popova I, Luo K, Sun X, Ahn J, et al. A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers. J Neurochem. 2017;142:934-947 pubmed publisher
|
| Hu X, Hu Z, Li Z, Ruan C, Qiu W, Pan A, et al. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum. Front Neuroanat. 2017;11:45 pubmed publisher
|
| Finke J, Ayres K, Brisbin R, Hill H, Wing E, Banks W. Antibody blood-brain barrier efflux is modulated by glycan modification. Biochim Biophys Acta Gen Subj. 2017;1861:2228-2239 pubmed publisher
|
| Wang X, Song R, Lu W, Liu Z, Wang L, Zhu X, et al. YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice. Front Aging Neurosci. 2017;9:157 pubmed publisher
|
| Xia F, Yiu A, Stone S, Oh S, Lozano A, Josselyn S, et al. Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer's Disease. Neuropsychopharmacology. 2017;42:2493-2503 pubmed publisher
|
| López Arias B, Turiegano E, Monedero I, Canal I, Torroja L. Presynaptic Aβ40 prevents synapse addition in the adult Drosophila neuromuscular junction. PLoS ONE. 2017;12:e0177541 pubmed publisher
|
| Amar F, Sherman M, Rush T, LARSON M, Boyle G, Chang L, et al. The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation. Sci Signal. 2017;10: pubmed publisher
|
| Valls Comamala V, Guivernau B, Bonet J, Puig M, Perálvarez Marín A, Palomer E, et al. The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers. Oncotarget. 2017;8:41154-41165 pubmed publisher
|
| Baek S, Park S, Jeong J, Kim S, Han J, Kyung J, et al. Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model. J Neurosci. 2017;37:5099-5110 pubmed publisher
|
| Abud E, Ramirez R, Martinez E, Healy L, Nguyen C, Newman S, et al. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017;94:278-293.e9 pubmed publisher
|
| Batarseh Y, Mohamed L, Al Rihani S, Mousa Y, Siddique A, El Sayed K, et al. Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies. Neuroscience. 2017;352:204-215 pubmed publisher
|
| Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun. 2017;5:26 pubmed publisher
|
| Kirouac L, Rajic A, Cribbs D, Padmanabhan J. Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease. Eneuro. 2017;4: pubmed publisher
|
| Nobili A, Latagliata E, Viscomi M, Cavallucci V, Cutuli D, Giacovazzo G, et al. Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease. Nat Commun. 2017;8:14727 pubmed publisher
|
| Lin T, Chang C, Chang Y, Liao Y, Yu H, Chen Y. Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity. PLoS ONE. 2017;12:e0174561 pubmed publisher
|
| Garcia Esparcia P, Lopez Gonzalez I, Grau Rivera O, García Garrido M, Konetti A, Llorens F, et al. Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms. Front Neurol. 2017;8:89 pubmed publisher
|
| Croft C, Wade M, Kurbatskaya K, Mastrandreas P, Hughes M, Phillips E, et al. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis. 2017;8:e2671 pubmed publisher
|
| Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, et al. Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease. Antioxid Redox Signal. 2017;27:1269-1280 pubmed publisher
|
| Poksay K, Sheffler D, Spilman P, Campagna J, Jagodzinska B, Descamps O, et al. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017;8:46 pubmed publisher
|
| Harach T, Marungruang N, Duthilleul N, Cheatham V, Mc Coy K, Frisoni G, et al. Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep. 2017;7:41802 pubmed publisher
|
| Schmidt K, Wienken M, Keller C, Balcarek P, MUNZ C, Schmidt J. IL-1β-Induced Accumulation of Amyloid: Macroautophagy in Skeletal Muscle Depends on ERK. Mediators Inflamm. 2017;2017:5470831 pubmed publisher
|
| Ye X, Feng T, Tammineni P, Chang Q, Jeong Y, Margolis D, et al. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease. J Neurosci. 2017;37:2639-2655 pubmed publisher
|
| Augé E, Cabezón I, Pelegri C, Vilaplana J. New perspectives on corpora amylacea in the human brain. Sci Rep. 2017;7:41807 pubmed publisher
|
| Vu H, Akatsu H, Hashizume Y, Setou M, Ikegami K. Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease. Sci Rep. 2017;7:40205 pubmed publisher
|
| Flanagan M, Marshall D, Shofer J, Montine K, Nelson P, Montine T, et al. Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease. J Neuropathol Exp Neurol. 2017;76:39-43 pubmed publisher
|
| Feng T, Tammineni P, Agrawal C, Jeong Y, Cai Q. Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation. J Biol Chem. 2017;292:1679-1690 pubmed publisher
|
| Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, et al. Young microglia restore amyloid plaque clearance of aged microglia. EMBO J. 2017;36:583-603 pubmed publisher
|
| Kaya I, Brinet D, Michno W, Syvänen S, Sehlin D, Zetterberg H, et al. Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry. ACS Chem Neurosci. 2017;8:347-355 pubmed publisher
|
| Reinders N, Pao Y, Renner M, Da Silva Matos C, Lodder T, Malinow R, et al. Amyloid-? effects on synapses and memory require AMPA receptor subunit GluA3. Proc Natl Acad Sci U S A. 2016;113:E6526-E6534 pubmed
|
| Pan H, Wang D, Zhang X, Zhou D, Zhang H, Qian Q, et al. Amyloid ? Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein. Stem Cell Reports. 2016;7:707-718 pubmed publisher
|
| Kimura A, Hata S, Suzuki T. Alternative Selection of ?-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid ?-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the A? Sequence. J Biol Chem. 2016;291:24041-24053 pubmed
|
| Sherman M, LaCroix M, Amar F, Larson M, Forster C, Aguzzi A, et al. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci. 2016;36:9647-58 pubmed publisher
|
| Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher
|
| Hernandez Rapp J, Rainone S, Goupil C, Dorval V, Smith P, Saint Pierre M, et al. microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. Sci Rep. 2016;6:30953 pubmed publisher
|
| Hostetler E, Walji A, Zeng Z, Miller P, Bennacef I, Salinas C, et al. Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles. J Nucl Med. 2016;57:1599-1606 pubmed
|
| Donner L, Fälker K, Gremer L, Klinker S, Pagani G, Ljungberg L, et al. Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release. Sci Signal. 2016;9:ra52 pubmed publisher
|
| Fu A, Hung K, Yuen M, Zhou X, Mak D, Chan I, et al. IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Proc Natl Acad Sci U S A. 2016;113:E2705-13 pubmed publisher
|
| Cifelli J, Dozier L, Chung T, Patrick G, Yang J. Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons. J Biol Chem. 2016;291:11981-92 pubmed publisher
|
| Omata Y, Tharasegaran S, Lim Y, Yamasaki Y, Ishigaki Y, Tatsuno T, et al. Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception. Aging (Albany NY). 2016;8:427-39 pubmed
|
| Baruch K, Deczkowska A, Rosenzweig N, Tsitsou Kampeli A, Sharif A, Matcovitch Natan O, et al. PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease. Nat Med. 2016;22:135-7 pubmed publisher
|
| Sandoval Hernández A, Buitrago L, Moreno H, Cardona Gómez G, Arboleda G. Role of Liver X Receptor in AD Pathophysiology. PLoS ONE. 2015;10:e0145467 pubmed publisher
|
| Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher
|
| Liu P, Reed M, Kotilinek L, Grant M, Forster C, Qiang W, et al. Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Rep. 2015;11:1760-71 pubmed publisher
|
| Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher
|
| Gowert N, Donner L, Chatterjee M, Eisele Y, Towhid S, Münzer P, et al. Blood platelets in the progression of Alzheimer's disease. PLoS ONE. 2014;9:e90523 pubmed publisher
|
| Zheng Y, Wang Q, Xiao B, Lu Q, Wang Y, Wang X. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and ?-amyloid deposition in Alzheimer's disease models. PLoS ONE. 2012;7:e39035 pubmed publisher
|
| Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed publisher
|
| Thakker D, Weatherspoon M, Harrison J, Keene T, Lane D, KAEMMERER W, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2009;106:4501-6 pubmed publisher
|
| Oddo S, Caccamo A, Green K, Liang K, Tran L, Chen Y, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005;102:3046-51 pubmed
|
| Herzig M, Winkler D, Burgermeister P, Pfeifer M, Kohler E, Schmidt S, et al. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004;7:954-60 pubmed
|