product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified (azide-free) anti-APP C-Terminal Fragment
catalog :
802803
quantity :
25 μL
price :
112 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C1/6.1
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
citations: 31
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; loading ...; fig 1i
Han X, Wang C, Song L, Wang X, Tang S, Hou T, et al. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022;78:103980 pubmed publisher
  • western blot; mouse; fig 6a
  • immunoprecipitation; human; fig 8e
Kim W, Watanabe H, Lomoio S, Tesco G. Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. J Biol Chem. 2021;296:100372 pubmed publisher
  • immunohistochemistry - frozen section; human; loading ...; fig 1b
Arber C, Lovejoy C, Harris L, Willumsen N, Alatza A, Casey J, et al. Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis. Cell Rep. 2021;34:108615 pubmed publisher
Ruan X, Hu K, Zhang X. PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing. Nat Commun. 2023;14:3275 pubmed publisher
Lin T, van Husen L, Yu Y, Tjernberg L, Schedin Weiss S. Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein. Glycobiology. 2022;32:506-517 pubmed publisher
Jiwaji Z, Tiwari S, Avil xe9 s Reyes R, Hooley M, Hampton D, Torvell M, et al. Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology. Nat Commun. 2022;13:135 pubmed publisher
Koh H, Lee S, Lee H, Min J, Iwatsubo T, Teunissen C, et al. Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression. Int J Mol Sci. 2021;22: pubmed publisher
Zhuravleva V, Vaz Silva J, Zhu M, Gomes P, Silva J, Sousa N, et al. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell Death Dis. 2021;12:1137 pubmed publisher
Hung C, Tuck E, Stubbs V, van der Lee S, Aalfs C, van Spaendonk R, et al. SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network. Cell Rep. 2021;35:109259 pubmed publisher
Bourdenx M, Martín Segura A, Scrivo A, Rodriguez Navarro J, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696-2714.e25 pubmed publisher
Lingel A, Lin H, Gavriel Y, Weaver E, Polepole P, Lopez V, et al. Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains. J Biol Chem. 2020;295:17114-17127 pubmed publisher
Lingel A, Lin H, Gavriel Y, Weaver E, Polepole P, Lopez V, et al. Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains. J Biol Chem. 2020;295:17114-17127 pubmed publisher
Liu Y, Hsu W, Ma Y, Lee E. Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation. Mol Ther. 2021;29:376-395 pubmed publisher
Chae C, Lee H, Choi G, Jung Y, Kim J, Lim J, et al. High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities. Br J Pharmacol. 2020;177:3828-3847 pubmed publisher
Arber C, Villegas Llerena C, Toombs J, Pocock J, Ryan N, Fox N, et al. Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout. Brain Commun. 2019;1:fcz024 pubmed publisher
Lundgren J, Vandermeulen L, Sandebring Matton A, Ahmed S, Winblad B, Di Luca M, et al. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain. BMC Neurosci. 2020;21:6 pubmed publisher
Arber C, Toombs J, Lovejoy C, Ryan N, Paterson R, Willumsen N, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Mol Psychiatry. 2019;: pubmed publisher
Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, et al. Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. EMBO Mol Med. 2019;11: pubmed publisher
Hung C, Livesey F. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease. Cell Rep. 2018;25:3647-3660.e2 pubmed publisher
Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, et al. P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model. J Exp Med. 2018;215:1649-1663 pubmed publisher
de Coninck D, Schmidt T, Schloetel J, Lang T. Packing Density of the Amyloid Precursor Protein in the Cell Membrane. Biophys J. 2018;114:1128-1141 pubmed publisher
Miranda A, Lasiecka Z, Xu Y, Neufeld J, Shahriar S, Simoes S, et al. Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Nat Commun. 2018;9:291 pubmed publisher
Jean Louis T, Rockwell P, Figueiredo Pereira M. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease. Neurobiol Aging. 2018;62:130-145 pubmed publisher
Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed publisher
Sogorb Esteve A, García Ayllón M, Llansola M, Felipo V, Blennow K, Saez Valero J. Inhibition of γ-Secretase Leads to an Increase in Presenilin-1. Mol Neurobiol. 2018;55:5047-5058 pubmed publisher
García Ayllón M, Lopez Font I, Boix C, Fortea J, Sanchez Valle R, Lleo A, et al. C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease. Sci Rep. 2017;7:2477 pubmed publisher
Kotfis K, Zegan Barańska M, Szydłowski Ł, Zukowski M, Ely E. Methods of pain assessment in adult intensive care unit patients - Polish version of the CPOT (Critical Care Pain Observation Tool) and BPS (Behavioral Pain Scale). Anaesthesiol Intensive Ther. 2017;49:66-72 pubmed publisher
Paschkowsky S, Hamzé M, Oestereich F, Munter L. Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. J Biol Chem. 2016;291:21903-21912 pubmed
Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed publisher
Shamji M, Layhadi J, Scadding G, Cheung D, Calderon M, Turka L, et al. Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response. J Allergy Clin Immunol. 2015;135:913-21.e9 pubmed publisher
Jiang Y, Mullaney K, Peterhoff C, Che S, Schmidt S, Boyer Boiteau A, et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A. 2010;107:1630-5 pubmed publisher
product information
Antigen :
APP C-Terminal Fragment
Apps. Abbrev. :
WB, ICC, IP
Cat # :
802803
Clone :
C1/6.1
Item :
Purified (azide-free) anti-APP C-Terminal Fragment
Isotype :
Mouse IgG1
Other Names :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Size :
25 μL
Price (USD) :
112 USD
Reactivity :
Human, Mouse, Rat
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PUREAF
Immunogen :
This antibody was raised against the conserved carboxyl-terminal 20 residues of APP (residues 676-695 of APP695).
Application Notes :
This antibody is effective in immunoblotting (WB), immunocytochemistry (ICC), and immunoprecipitation (IP).;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA