| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; fig 6a
- immunoprecipitation; human; fig 8e
| Kim W, Watanabe H, Lomoio S, Tesco G. Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. J Biol Chem. 2021;296:100372 pubmed publisher |
- proximity ligation assay; rat; 1:1000; loading ...; fig 2a
| Lundgren J, Vandermeulen L, Sandebring Matton A, Ahmed S, Winblad B, Di Luca M, et al. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain. BMC Neurosci. 2020;21:6 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3h
| Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, et al. Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. EMBO Mol Med. 2019;11: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s1b
| Real R, Peter M, Trabalza A, Khan S, Smith M, Dopp J, et al. In vivo modeling of human neuron dynamics and Down syndrome. Science. 2018;362: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6t
| Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, et al. P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model. J Exp Med. 2018;215:1649-1663 pubmed publisher |
- proximity ligation assay; rat; fig 5D
| Canu N, Pagano I, La Rosa L, Pellegrino M, Ciotti M, Mercanti D, et al. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front Mol Neurosci. 2017;10:15 pubmed publisher |
- western blot; mouse; 1:1000; fig 8
| Porquet D, Andrés Benito P, Griñán Ferré C, Camins A, Ferrer I, Canudas A, et al. Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordr). 2015;37:9747 pubmed publisher |
- western blot; mouse; 1:1000
| Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed publisher |
- western blot; human; fig 1
| Maarouf C, Kokjohn T, Walker D, Whiteside C, Kalback W, Whetzel A, et al. Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease. PLoS ONE. 2014;9:e105784 pubmed publisher |
- western blot; mouse; 1:1000
| Kang E, Kwon I, Koo J, Kim E, Kim C, Lee J, et al. Treadmill exercise represses neuronal cell death and inflammation during A?-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis. 2013;18:1332-1347 pubmed publisher |
| Lin T, van Husen L, Yu Y, Tjernberg L, Schedin Weiss S. Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein. Glycobiology. 2022;32:506-517 pubmed publisher |
| Zhuravleva V, Vaz Silva J, Zhu M, Gomes P, Silva J, Sousa N, et al. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production. Cell Death Dis. 2021;12:1137 pubmed publisher |
| Hung C, Tuck E, Stubbs V, van der Lee S, Aalfs C, van Spaendonk R, et al. SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network. Cell Rep. 2021;35:109259 pubmed publisher |
| Bourdenx M, Martín Segura A, Scrivo A, Rodriguez Navarro J, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696-2714.e25 pubmed publisher |
| Arber C, Lovejoy C, Harris L, Willumsen N, Alatza A, Casey J, et al. Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis. Cell Rep. 2021;34:108615 pubmed publisher |
| Lingel A, Lin H, Gavriel Y, Weaver E, Polepole P, Lopez V, et al. Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains. J Biol Chem. 2020;295:17114-17127 pubmed publisher |
| Arber C, Villegas Llerena C, Toombs J, Pocock J, Ryan N, Fox N, et al. Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout. Brain Commun. 2019;1:fcz024 pubmed publisher |
| Arber C, Toombs J, Lovejoy C, Ryan N, Paterson R, Willumsen N, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Mol Psychiatry. 2019;: pubmed publisher |
| Hung C, Livesey F. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease. Cell Rep. 2018;25:3647-3660.e2 pubmed publisher |
| de Coninck D, Schmidt T, Schloetel J, Lang T. Packing Density of the Amyloid Precursor Protein in the Cell Membrane. Biophys J. 2018;114:1128-1141 pubmed publisher |
| Miranda A, Lasiecka Z, Xu Y, Neufeld J, Shahriar S, Simoes S, et al. Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Nat Commun. 2018;9:291 pubmed publisher |
| Jean Louis T, Rockwell P, Figueiredo Pereira M. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease. Neurobiol Aging. 2018;62:130-145 pubmed publisher |
| Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed publisher |
| Sogorb Esteve A, García Ayllón M, Llansola M, Felipo V, Blennow K, Saez Valero J. Inhibition of γ-Secretase Leads to an Increase in Presenilin-1. Mol Neurobiol. 2018;55:5047-5058 pubmed publisher |
| García Ayllón M, Lopez Font I, Boix C, Fortea J, Sanchez Valle R, Lleo A, et al. C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease. Sci Rep. 2017;7:2477 pubmed publisher |
| Kotfis K, Zegan Barańska M, Szydłowski Ł, Zukowski M, Ely E. Methods of pain assessment in adult intensive care unit patients - Polish version of the CPOT (Critical Care Pain Observation Tool) and BPS (Behavioral Pain Scale). Anaesthesiol Intensive Ther. 2017;49:66-72 pubmed publisher |
| Paschkowsky S, Hamzé M, Oestereich F, Munter L. Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. J Biol Chem. 2016;291:21903-21912 pubmed |
| Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed publisher |
| Jiang Y, Mullaney K, Peterhoff C, Che S, Schmidt S, Boyer Boiteau A, et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A. 2010;107:1630-5 pubmed publisher |
