product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified (azide-free) anti-β-Amyloid, 17-24
catalog :
800712
quantity :
25 μL
price :
112 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G8
reactivity :
human, mouse
application :
ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 128
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:400; loading ...; fig 1d
Han X, Wang C, Song L, Wang X, Tang S, Hou T, et al. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022;78:103980 pubmed publisher
  • immunohistochemistry - free floating section; human; 1:5000; loading ...
Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1b
Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed publisher
  • immunohistochemistry; human; 1:9,000; loading ...; tbl 2
Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5g
Wang Z, Xiang J, Liu X, Yu S, Manfredsson F, Sandoval I, et al. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019;28:655-669.e5 pubmed publisher
Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, et al. CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue. BMC Biol. 2023;21:113 pubmed publisher
Lia A, Sansevero G, Chiavegato A, Sbrissa M, Pendin D, Mariotti L, et al. Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer's disease. Nat Commun. 2023;14:1590 pubmed publisher
Campbell N, Patel Y, Moore T, Medalla M, Zeldich E. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome. Int J Mol Sci. 2023;24: pubmed publisher
Natarajan C, Cook C, Ramaswamy K, Krishnan B. Phospholipase D1 Attenuation Therapeutics Promotes Resilience against Synaptotoxicity in 12-Month-Old 3xTg-AD Mouse Model of Progressive Neurodegeneration. Int J Mol Sci. 2023;24: pubmed publisher
Williams D, Yan B, Wang H, Negm L, Sackmann C, Verkuyl C, et al. Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation. Sci Rep. 2023;13:2337 pubmed publisher
De Schepper S, Ge J, Crowley G, Ferreira L, Garceau D, Toomey C, et al. Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease. Nat Neurosci. 2023;26:406-415 pubmed publisher
Grochowska K, Gomes G, Raman R, Kaushik R, Sosulina L, Kaneko H, et al. Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. EMBO J. 2023;:e112453 pubmed publisher
Jiang Y, Zhou X, Wong H, Ouyang L, Ip F, Chau V, et al. An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease. Nat Aging. 2022;2:616-634 pubmed publisher
Rudan Njavro J, Vukicevic M, Fiorini E, Dinkel L, M xfc ller S, Berghofer A, et al. Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model. Cells. 2022;12: pubmed publisher
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Shimada H, Sato Y, Sasaki T, Shimozawa A, Imaizumi K, Shindo T, et al. A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer. Cell Rep Methods. 2022;2:100289 pubmed publisher
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Wang Q, Huang X, Su Y, Yin G, Wang S, Yu B, et al. Activation of Wnt/β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease. Brain. 2022;145:4474-4488 pubmed publisher
Yu W, Aquili L, Wong K, Lo A, Chan L, Chan Y, et al. Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models. Ann N Y Acad Sci. 2022;1515:249-265 pubmed publisher
Espinoza S, Grunenwald F, Gómez W, Garc xed a F, Abarz xfa a Catalan L, Oyarce Pezoa S, et al. Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer's Disease. Cells. 2022;11: pubmed publisher
Lee J, Yang D, Goulbourne C, Im E, Stavrides P, Pensalfini A, et al. Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nat Neurosci. 2022;: pubmed publisher
Feilen L, Chen S, Fukumori A, Feederle R, Zacharias M, Steiner H. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis. elife. 2022;11: pubmed publisher
Melikyan Z, Corrada M, Leiby A, Sajjadi S, Bukhari S, Montine T, et al. Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study. Neurobiol Aging. 2022;116:12-15 pubmed publisher
Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, et al. Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease. Brain Neurosci Adv. 2022;6:23982128221086464 pubmed publisher
Fixemer S, Ameli C, Hammer G, Salamanca L, Uriarte Huarte O, Schwartz C, et al. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol Commun. 2022;10:36 pubmed publisher
Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, et al. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. iScience. 2022;25:103869 pubmed publisher
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Liu S, Fan M, Xu J, Yang L, Qi C, Xia Q, et al. Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology. J Neuroinflammation. 2022;19:35 pubmed publisher
Wirianto M, Wang C, Kim E, Koike N, Gomez Gutierrez R, Nohara K, et al. The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer's disease model. FASEB J. 2022;36:e22186 pubmed publisher
Dahl M, Mather M, Werkle Bergner M, Kennedy B, Guzman S, Hurth K, et al. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiol Aging. 2022;112:39-54 pubmed publisher
Moon H, Haroutunian V, Zhao L. Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation. Neurobiol Dis. 2022;164:105631 pubmed publisher
Abrahamson E, Kofler J, Becker C, Price J, Newell K, Ghetti B, et al. 11C-PiB PET can underestimate brain amyloid-β burden when cotton wool plaques are numerous. Brain. 2022;145:2161-2176 pubmed publisher
Smith A, DAVEY K, Tsartsalis S, Khozoie C, Fancy N, Tang S, et al. Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology. Acta Neuropathol. 2022;143:75-91 pubmed publisher
Wang C, Huang W, Lu J, Chen H, Yu Z. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline. Front Pharmacol. 2021;12:763866 pubmed publisher
Carranza Naval M, Del Marco Á, Hierro Bujalance C, Alves Martínez P, Infante Garcia C, Vargas Soria M, et al. Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer's Disease and Type 2 Diabetes. Front Aging Neurosci. 2021;13:741923 pubmed publisher
Schober R, Hilbrich I, J xe4 ger C, Holzer M. Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease. Neuropathology. 2021;41:366-370 pubmed publisher
Kim E, Nohara K, Wirianto M, Escobedo G, Lim J, Morales R, et al. Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer's Disease Model. Biomolecules. 2021;11: pubmed publisher
Illouz T, Madar R, Hirsh T, Biragyn A, Okun E. Induction of an effective anti-Amyloid-β humoral response in aged mice. Vaccine. 2021;39:4817-4829 pubmed publisher
Mol M, Wong T, Melhem S, Basu S, Viscusi R, Galjart N, et al. Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia. Neurol Genet. 2021;7:e596 pubmed publisher
Kim E, Di Censo D, Baraldo M, Simmons C, Rosa I, Randall K, et al. In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer's disease. Sci Rep. 2021;11:12419 pubmed publisher
Cao K, Kim J, Kroeger H, Gaffney P, Lin J, Sigurdson C, et al. ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol. 2021;10:5 pubmed publisher
Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, et al. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein Cell. 2021;12:695-716 pubmed publisher
Lu J, Zhou W, Dou F, Wang C, Yu Z. TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease. EMBO Rep. 2021;22:e52013 pubmed publisher
Liu X, Qi X, Fang H, Zhou K, Wang Q, Chen G. Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease. Front Aging Neurosci. 2021;13:639318 pubmed publisher
Van Skike C, Hussong S, Hernandez S, Banh A, Derosa N, Galvan V. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. J Neurosci. 2021;41:4305-4320 pubmed publisher
Wang Z, Xia Y, Liu P, Liu X, Edgington Mitchell L, Lei K, et al. ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2021;202:102032 pubmed publisher
Libard S, Walter J, Alafuzoff I. In vivo Characterization of Biochemical Variants of Amyloid-β in Subjects with Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease Neuropathological Change. J Alzheimers Dis. 2021;80:1003-1012 pubmed publisher
Crivelli S, Luo Q, Stevens J, Giovagnoni C, van Kruining D, Bode G, et al. CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's disease. Alzheimers Res Ther. 2021;13:45 pubmed publisher
Yamamoto S, Kayama T, Noguchi Shinohara M, Hamaguchi T, Yamada M, Abe K, et al. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. NPJ Sci Food. 2021;5:1 pubmed publisher
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Fassler M, Rappaport M, Cuño C, George J. Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models. J Neuroinflammation. 2021;18:19 pubmed publisher
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product information
Antigen :
beta-Amyloid 17-24
Apps. Abbrev. :
IHC-P, Direct ELISA, IHC-F, ICC, IP
Cat # :
800712
Clone :
4G8
Item :
Purified (azide-free) anti-β-Amyloid, 17-24
Isotype :
Mouse IgG2b, κ
Other Names :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Size :
25 μL
Price (USD) :
112 USD
Reactivity :
Human, Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PUREAF
Application Notes :
This antibody is reactive to amino acid residues 17-24 of ß amyloid. The epitope lies within amino acids 18-22 of ß amyloid (VFFAE). 4G8 ß-amyloid antibody reacts to abnormally processed isoforms, as well as precursor forms.This antibody clone has been reported for use on IHC of free-floating sections in PBS containing 1% Triton incubated with 0.1 m citrate buffer (4).Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue sections (IHC-F) and immunocytochemistry (ICC);
more info or order :
company information
BioLegend
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San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA