| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - free floating section; human; 1:5000; loading ...
| Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1b
| Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed publisher |
- immunohistochemistry; human; 1:9,000; loading ...; tbl 2
| Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed publisher |
- immunohistochemistry; human; 1:500; loading ...; fig 2e
| Dominy S, LYNCH C, Ermini F, Benedyk M, Marczyk A, Konradi A, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5:eaau3333 pubmed publisher |
- blocking or activating experiments; human; fig 3
- immunohistochemistry; human; fig 2
| Kumar D, Choi S, Washicosky K, Eimer W, Tucker S, Ghofrani J, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med. 2016;8:340ra72 pubmed publisher |
- immunoprecipitation; human; fig 4
| Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed publisher |
- ELISA; mouse; 1:2500; fig 2
- western blot; mouse; fig 1
| Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed publisher |
- immunohistochemistry; mouse; fig 2i
- western blot; mouse; fig 2f
| Tapia Rojas C, Lindsay C, Montecinos Oliva C, Arrázola M, Retamales R, Bunout D, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62 pubmed publisher |
- immunohistochemistry; human; 1:250; fig 5
- immunohistochemistry; mouse; 1:250; fig 5
| Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed publisher |
- immunoprecipitation; mouse
| Howell M, Bailey L, Cozart M, Gannon B, Gottschall P. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015;3:54 pubmed publisher |
- immunohistochemistry; human; tbl 1
| Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 1f
| Bhatt D, Puig K, Gorr M, Wold L, Combs C. A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain. PLoS ONE. 2015;10:e0127102 pubmed publisher |
- immunohistochemistry - frozen section; human
| Rotman M, Welling M, van den Boogaard M, Moursel L, van der Graaf L, van Buchem M, et al. Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake. Nucl Med Biol. 2015;42:695-702 pubmed publisher |
- immunoprecipitation; human
| Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed publisher |
- immunohistochemistry - free floating section; mouse
| Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed publisher |
- western blot; human; 1:500
| López González I, Schlüter A, Aso E, Garcia Esparcia P, Ansoleaga B, Llorens F, et al. Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species. J Neuropathol Exp Neurol. 2015;74:319-44 pubmed publisher |
- immunohistochemistry; human; 1:400
| Jensen M, Arvaniti M, Mikkelsen J, Michalski D, Pinborg L, Härtig W, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015;36:1629-1638 pubmed publisher |
- immunohistochemistry; mouse; fig s2
| Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun. 2015;6:6176 pubmed publisher |
- immunohistochemistry; mouse; 1:150
| Fine J, Renner D, Forsberg A, Cameron R, Galick B, Le C, et al. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neurosci Lett. 2015;584:362-7 pubmed publisher |
- immunocytochemistry; mouse; 1:1000
| Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:250
| Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed publisher |
- immunohistochemistry; mouse; 1 ug/ml
- ELISA; mouse
| Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, et al. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. J Biol Chem. 2014;289:27080-9 pubmed publisher |
- immunoprecipitation; human
- ELISA; human
- western blot; human
| Toyn J, Thompson L, Lentz K, Meredith J, Burton C, Sankaranararyanan S, et al. Identification and Preclinical Pharmacology of the ?-Secretase Modulator BMS-869780. Int J Alzheimers Dis. 2014;2014:431858 pubmed publisher |
- immunohistochemistry; human; 1:200
| Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed publisher |
- immunoprecipitation; mouse
| Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed publisher |
| Sato W, Watanabe Takahashi M, Murata T, Utsunomiya Tate N, Motoyama J, Anzai M, et al. A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation. Commun Biol. 2023;6:383 pubmed publisher |
| Tournier B, Snoeijs C, Tsartsalis S, Amoss xe9 Q, Farchoukh R, K xf6 vari E, et al. The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. Aging Brain. 2022;2:100045 pubmed publisher |
| Gamez N, Bravo Alegria J, Huang Y, Perez Urrutia N, Dongarwar D, Soto C, et al. Altering Brain Amyloidosis by Intra-Lingual and Extra-Nasal Exposure of Aβ Aggregates. Cells. 2022;11: pubmed publisher |
| Chaudry O, Ndukwe K, Xie L, FIGUEIREDO PEREIRA M, Serrano P, Rockwell P. Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats. Sci Rep. 2022;12:19129 pubmed publisher |
| Mu L, Xia D, Cai J, Gu B, Liu X, Friedman V, et al. Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 × Tg-AD Mice. Int J Mol Sci. 2022;23: pubmed publisher |
| Bluhm A, Schrempel S, Schilling S, von H xf6 rsten S, Schulze A, Ro xdf ner S, et al. Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer's Disease and Its Tg2576 Mouse Model. Biomolecules. 2022;12: pubmed publisher |
| Taddei R, Sanchez Mico M, Bonnar O, Connors T, Gaona A, Denbow D, et al. Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages. Acta Neuropathol Commun. 2022;10:72 pubmed publisher |
| Jiwaji Z, Tiwari S, Avil xe9 s Reyes R, Hooley M, Hampton D, Torvell M, et al. Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology. Nat Commun. 2022;13:135 pubmed publisher |
| Maxwell A, Yuan P, Rivera B, Schaaf W, Mladinov M, Prasher V, et al. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta Neuropathol Commun. 2021;9:201 pubmed publisher |
| Woelfle S, Boeckers T. Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including the Stratum lucidum. Front Cell Neurosci. 2021;15:789903 pubmed publisher |
| Zhang J, Gao F, Ma Y, Xue T, Shen Y. Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease. iScience. 2021;24:103327 pubmed publisher |
| Gkanatsiou E, Nilsson J, Toomey C, Vrillon A, Kvartsberg H, Portelius E, et al. Amyloid pathology and synaptic loss in pathological aging. J Neurochem. 2021;159:258-272 pubmed publisher |
| Morales R, Bravo Alegria J, Moreno Gonzalez I, Duran Aniotz C, Gamez N, Edwards Iii G, et al. Transmission of cerebral amyloid pathology by peripheral administration of misfolded Aβ aggregates. Mol Psychiatry. 2021;26:5690-5701 pubmed publisher |
| Martin L, Bouvet P, Chounlamountri N, Watrin C, Besancon R, Pinatel D, et al. VEGF counteracts amyloid-β-induced synaptic dysfunction. Cell Rep. 2021;35:109121 pubmed publisher |
| Shen Y, Hua L, Yeh C, Shen L, Ying M, Zhang Z, et al. Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease. Theranostics. 2020;10:11794-11819 pubmed publisher |
| Koronyo Hamaoui M, Sheyn J, Hayden E, Li S, Fuchs D, Regis G, et al. Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease. Brain. 2020;143:336-358 pubmed publisher |
| Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher |
| Tang Z, Chuang K, DeCarli C, Jin L, Beckett L, Keiser M, et al. Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. Nat Commun. 2019;10:2173 pubmed publisher |
| Boeddrich A, Babila J, Wiglenda T, Diez L, Jacob M, Nietfeld W, et al. The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chem Biol. 2019;26:109-120.e7 pubmed publisher |
| Klakotskaia D, Agca C, Richardson R, Stopa E, Schachtman T, Agca Y. Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. PLoS ONE. 2018;13:e0195469 pubmed publisher |
| Lee C, Daggett A, Gu X, Jiang L, Langfelder P, Li X, et al. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018;97:1032-1048.e5 pubmed publisher |
| Robertson A, Majchrzak M, Smith C, Gagnon R, Devidze N, Banks G, et al. Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents. Neuromuscul Disord. 2017;27:635-645 pubmed publisher |
| Scholtzova H, Do E, Dhakal S, Sun Y, Liu S, Mehta P, et al. Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits. J Neurosci. 2017;37:936-959 pubmed publisher |
| Schaefer P, von Einem B, Walther P, Calzia E, von Arnim C. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. PLoS ONE. 2016;11:e0168157 pubmed publisher |
| Whitehouse I, Brown D, Baybutt H, Diack A, Kellett K, Piccardo P, et al. Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-? or Pathologic Phenotype. PLoS ONE. 2016;11:e0159119 pubmed publisher |
| Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016;50:517-25 pubmed publisher |
| Lessard C, Cottrell B, Maruyama H, Suresh S, Golde T, Koo E. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). PLoS ONE. 2015;10:e0144758 pubmed publisher |
| Choi S, Kim D, Kam T, Yun S, Kim S, Park H, et al. Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. PLoS ONE. 2015;10:e0143854 pubmed publisher |
| Liu P, Reed M, Kotilinek L, Grant M, Forster C, Qiang W, et al. Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Rep. 2015;11:1760-71 pubmed publisher |
| Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher |
| Abramowski D, Rabe S, Upadhaya A, Reichwald J, Danner S, Staab D, et al. Transgenic expression of intraneuronal A?42 but not A?40 leads to cellular A? lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci. 2012;32:1273-83 pubmed publisher |
| Chapuis J, Vingtdeux V, Capiralla H, Davies P, Marambaud P. Gas1 interferes with A?PP trafficking by facilitating the accumulation of immature A?PP in endoplasmic reticulum-associated raft subdomains. J Alzheimers Dis. 2012;28:127-35 pubmed publisher |
