product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Biotin (azide-free) anti-β-Amyloid, 17-24
catalog :
800705
quantity :
500 μL
price :
1292 USD
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
4G8
reactivity :
human, mouse, rat
application :
ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 21
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; human; 1:5000; loading ...
Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1b
Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed publisher
  • immunohistochemistry; human; 1:9,000; loading ...; tbl 2
Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed publisher
  • immunohistochemistry; human; 1:400
Jensen M, Arvaniti M, Mikkelsen J, Michalski D, Pinborg L, Härtig W, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015;36:1629-1638 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:4000
Deng X, Li M, Ai W, He L, Lu D, Patrylo P, et al. Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats. Adv Alzheimer Dis. 2014;3:78-93 pubmed
Sun X, Yu X, Zhu J, Li L, Zhang L, Huang Y, et al. Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer's disease-like mouse model. Signal Transduct Target Ther. 2023;8:30 pubmed publisher
Lam S, H xe9 rard A, Boluda S, Petit F, Eddarkaoui S, Cambon K, et al. Pathological changes induced by Alzheimer's brain inoculation in amyloid-beta plaque-bearing mice. Acta Neuropathol Commun. 2022;10:112 pubmed publisher
Luo M, Zeng Q, Jiang K, Zhao Y, Long Z, Du Y, et al. Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice. Genes Dis. 2022;9:1315-1331 pubmed publisher
Jung E, Suh K, Han J, Kim H, Kang H, Choi W, et al. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging Cell. 2022;21:e13623 pubmed publisher
Forgrave L, van der Gugten J, Nguyen Q, DeMarco M. Establishing pre-analytical requirements and maximizing peptide recovery in the analytical phase for mass spectrometric quantification of amyloid-β peptides 1-42 and 1-40 in CSF. Clin Chem Lab Med. 2022;60:198-206 pubmed publisher
Clayton K, Delpech J, Herron S, Iwahara N, Ericsson M, Saito T, et al. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021;16:18 pubmed publisher
Do T, Capdevila C, Pradier L, Blanchard V, Lopez Grancha M, Schussler N, et al. Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model. Mol Ther Methods Clin Dev. 2020;19:58-77 pubmed publisher
Elmer B, Swanson K, Bangari D, Piepenhagen P, Roberts E, Taksir T, et al. Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease. PLoS ONE. 2019;14:e0226245 pubmed publisher
Chen J, Long Z, Li Y, Luo M, Luo S, He G. Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model. Int J Mol Med. 2019;44:313-323 pubmed publisher
Yao Q, Feng M, Yang B, Long Z, Luo S, Luo M, et al. Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice. Acta Biochim Biophys Sin (Shanghai). 2018;50:447-455 pubmed publisher
Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016;50:517-25 pubmed publisher
Hong J, Kang J, Kim D, Baik S, Kim K, Shanta S, et al. Global changes of phospholipids identified by MALDI imaging mass spectrometry in a mouse model of Alzheimer's disease. J Lipid Res. 2016;57:36-45 pubmed publisher
Bales K, O Neill S, Pozdnyakov N, Pan F, Caouette D, Pi Y, et al. Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity. Brain. 2016;139:563-77 pubmed publisher
Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher
Watanabe H, Xia D, Kanekiyo T, Kelleher R, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012;32:5085-96 pubmed publisher
Townsend M, Qu Y, Gray A, Wu Z, Seto T, Hutton M, et al. Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther. 2010;333:110-9 pubmed publisher
product information
Antigen :
beta-Amyloid 17-24
Apps. Abbrev. :
IHC-P, Direct ELISA
Cat # :
800705
Clone :
4G8
Item :
Biotin (azide-free) anti-β-Amyloid, 17-24
Isotype :
Mouse IgG2b, κ
Other Names :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Size :
500 μL
Price (USD) :
1292 USD
Reactivity :
Human, Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
BIOTINAF
Application Notes :
This antibody is reactive to amino acid residues 17-24 of ß amyloid. The epitope lies within amino acids 18-22 of ß amyloid (VFFAE). 4G8 ß-amyloid antibody reacts to abnormally processed isoforms, as well as precursor forms.This antibody clone has been reported for use on IHC of free-floating sections in PBS containing 1% Triton incubated with 0.1 m citrate buffer (4).Additional reported applications (for the relevant formats) include: immunohistochemical staining on frozen tissue sections (IHC-F) and immunocytochemistry (ICC);
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA