| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; human; loading ...; fig 1c
| Rauskolb S, Andreska T, Fries S, von Collenberg C, Blum R, Monoranu C, et al. Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment. Acta Neuropathol Commun. 2022;10:68 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 7a
- immunohistochemistry - paraffin section; mouse; loading ...; fig 6a
| Honarpisheh P, Reynolds C, Blasco Conesa M, Moruno Manchon J, Putluri N, Bhattacharjee M, et al. Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice. Int J Mol Sci. 2020;21: pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig s6e
| Yan T, Liang J, Gao J, Wang L, Fujioka H, Zhu X, et al. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nat Commun. 2020;11:411 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 3c
| Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher |
- immunohistochemistry - free floating section; human; 1:5000; loading ...
| Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:2000; loading ...; fig s8g
| Bhattarai P, Cosacak M, Mashkaryan V, Demir S, Popova S, Govindarajan N, et al. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. PLoS Biol. 2020;18:e3000585 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1b
| Smith R, Pawlik D, Nilsson C, Englund E, Hansson O. [18F]Flortaucipir distinguishes Alzheimer's disease from progressive supranuclear palsy pathology in a mixed-pathology case. Acta Neuropathol. 2020;139:411-413 pubmed publisher |
- immunohistochemistry - frozen section; fruit fly ; 1:500; loading ...; fig 3c
| Bergkvist L, Du Z, Elovsson G, Appelqvist H, Itzhaki L, Kumita J, et al. Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease. FEBS Open Bio. 2020;10:338-350 pubmed publisher |
- immunohistochemistry; human; 1:9,000; loading ...; tbl 2
| Yu L, Boyle P, Dawe R, Bennett D, Arfanakis K, Schneider J. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020;94:e142-e152 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 3c
| Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher |
- immunocytochemistry; rat; loading ...; fig s4b
| Latina V, Caioli S, Zona C, Ciotti M, Amadoro G, Calissano P. Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons. Front Cell Neurosci. 2017;11:68 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1a
| Guillot Sestier M, Weitz T, Town T. Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease. J Vis Exp. 2016;: pubmed publisher |
- immunohistochemistry - paraffin section; rat; 1:2000; fig 3
| Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, et al. Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta Neuropathol Commun. 2016;4:91 pubmed publisher |
- immunohistochemistry - free floating section; human; 1:1000; loading ...; fig 7c
- immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 7c
- immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 3b
- immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 3b
- western blot; mouse; 1:2000; loading ...; fig st7
| Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed |
- immunohistochemistry - paraffin section; human; 1:500; fig 2
| Shively S, Horkayne Szakaly I, Jones R, Kelly J, Armstrong R, Perl D. Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series. Lancet Neurol. 2016;15:944-953 pubmed publisher |
- blocking or activating experiments; human; fig 3
- immunohistochemistry; human; fig 2
| Kumar D, Choi S, Washicosky K, Eimer W, Tucker S, Ghofrani J, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med. 2016;8:340ra72 pubmed publisher |
- immunoprecipitation; human; 1:500-1:2500; fig 1H
| Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn P, Kremmer E, et al. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med. 2016;8:458-65 pubmed publisher |
- immunoprecipitation; human; fig 4
| Reinert J, Richard B, Klafki H, Friedrich B, Bayer T, Wiltfang J, et al. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun. 2016;4:24 pubmed publisher |
- ELISA; mouse; 1:2500; fig 2
- western blot; mouse; fig 1
| Müller Schiffmann A, Herring A, Abdel Hafiz L, Chepkova A, Schäble S, Wedel D, et al. Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016;139:509-25 pubmed publisher |
- immunohistochemistry; mouse; fig 2i
- western blot; mouse; fig 2f
| Tapia Rojas C, Lindsay C, Montecinos Oliva C, Arrázola M, Retamales R, Bunout D, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62 pubmed publisher |
- immunohistochemistry; mouse; 1:250; fig 5
- immunohistochemistry; human; 1:250; fig 5
| Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed publisher |
- immunoprecipitation; mouse
| Howell M, Bailey L, Cozart M, Gannon B, Gottschall P. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015;3:54 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; tbl 3
| Keable A, Fenna K, Yuen H, Johnston D, Smyth N, Smith C, et al. Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy. Biochim Biophys Acta. 2016;1862:1037-46 pubmed publisher |
- immunohistochemistry; human; tbl 1
| Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher |
- immunohistochemistry; human; fig 3
| Lutzenberger M, Burwinkel M, Riemer C, Bode V, Baier M. Ablation of CCAAT/Enhancer-Binding Protein Delta (C/EBPD): Increased Plaque Burden in a Murine Alzheimer's Disease Model. PLoS ONE. 2015;10:e0134228 pubmed publisher |
- immunohistochemistry; human; 1:500; fig 2
| Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, et al. Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes. J Neuropathol Exp Neurol. 2015;74:873-88 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Tan X, Xue Y, Ma T, Wang X, Li J, Lan L, et al. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015;10:24 pubmed publisher |
- immunohistochemistry; human; 1:500
| Iacono D, Geraci Erck M, Peng H, Rabin M, Kurlan R. Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses. Tremor Other Hyperkinet Mov (N Y). 2015;5: pubmed publisher |
- immunohistochemistry - frozen section; human
| Rotman M, Welling M, van den Boogaard M, Moursel L, van der Graaf L, van Buchem M, et al. Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake. Nucl Med Biol. 2015;42:695-702 pubmed publisher |
- immunoprecipitation; human
| Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed publisher |
- immunohistochemistry - free floating section; mouse
| Leinenga G, Götz J. Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed publisher |
- western blot; human; 1:500
| López González I, Schlüter A, Aso E, Garcia Esparcia P, Ansoleaga B, Llorens F, et al. Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species. J Neuropathol Exp Neurol. 2015;74:319-44 pubmed publisher |
- immunohistochemistry; human; 1:400
| Jensen M, Arvaniti M, Mikkelsen J, Michalski D, Pinborg L, Härtig W, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015;36:1629-1638 pubmed publisher |
- immunohistochemistry; human; 1:1000
| Vallortigara J, Rangarajan S, Whitfield D, Alghamdi A, Howlett D, Hortobágyi T, et al. Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia. F1000Res. 2014;3:108 pubmed publisher |
- immunohistochemistry; mouse; 1:150
| Fine J, Renner D, Forsberg A, Cameron R, Galick B, Le C, et al. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neurosci Lett. 2015;584:362-7 pubmed publisher |
- western blot; human; 1:1000
| Thomzig A, Wagenführ K, Daus M, Joncic M, Schulz Schaeffer W, Thanheiser M, et al. Decontamination of medical devices from pathological amyloid-?-, tau- and ?-synuclein aggregates. Acta Neuropathol Commun. 2014;2:151 pubmed publisher |
- immunocytochemistry; mouse; 1:1000
| Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed publisher |
- immunohistochemistry - free floating section; rat; 1:200
| Forny Germano L, Lyra e Silva N, Batista A, Brito Moreira J, Gralle M, Boehnke S, et al. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J Neurosci. 2014;34:13629-43 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:250
| Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed publisher |
- immunohistochemistry; mouse; 1 ug/ml
- ELISA; mouse
| Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, et al. Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease. J Biol Chem. 2014;289:27080-9 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000
| Whitfield D, Vallortigara J, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, et al. Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment. Neurobiol Aging. 2014;35:2836-2844 pubmed publisher |
- immunoprecipitation; human
- ELISA; human
- western blot; human
| Toyn J, Thompson L, Lentz K, Meredith J, Burton C, Sankaranararyanan S, et al. Identification and Preclinical Pharmacology of the ?-Secretase Modulator BMS-869780. Int J Alzheimers Dis. 2014;2014:431858 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:500
| Fu Y, Rusznák Z, Kwok J, Kim W, Paxinos G. Age-dependent alterations of the hippocampal cell composition and proliferative potential in the hA?PPSwInd-J20 mouse. J Alzheimers Dis. 2014;41:1177-92 pubmed publisher |
- immunohistochemistry; human; 1:200
| Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed publisher |
- immunoprecipitation; mouse
| Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed publisher |
| Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, et al. CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue. BMC Biol. 2023;21:113 pubmed publisher |
| Lia A, Sansevero G, Chiavegato A, Sbrissa M, Pendin D, Mariotti L, et al. Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer's disease. Nat Commun. 2023;14:1590 pubmed publisher |
| Campbell N, Patel Y, Moore T, Medalla M, Zeldich E. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome. Int J Mol Sci. 2023;24: pubmed publisher |
| Natarajan C, Cook C, Ramaswamy K, Krishnan B. Phospholipase D1 Attenuation Therapeutics Promotes Resilience against Synaptotoxicity in 12-Month-Old 3xTg-AD Mouse Model of Progressive Neurodegeneration. Int J Mol Sci. 2023;24: pubmed publisher |
| Williams D, Yan B, Wang H, Negm L, Sackmann C, Verkuyl C, et al. Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation. Sci Rep. 2023;13:2337 pubmed publisher |
| De Schepper S, Ge J, Crowley G, Ferreira L, Garceau D, Toomey C, et al. Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease. Nat Neurosci. 2023;26:406-415 pubmed publisher |
| Grochowska K, Gomes G, Raman R, Kaushik R, Sosulina L, Kaneko H, et al. Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. EMBO J. 2023;:e112453 pubmed publisher |
| Jiang Y, Zhou X, Wong H, Ouyang L, Ip F, Chau V, et al. An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease. Nat Aging. 2022;2:616-634 pubmed publisher |
| Rudan Njavro J, Vukicevic M, Fiorini E, Dinkel L, M xfc ller S, Berghofer A, et al. Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model. Cells. 2022;12: pubmed publisher |
| Libard S, Giedraitis V, Kilander L, Ingelsson M, Alafuzoff I. Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation. J Alzheimers Dis. 2022;90:1601-1614 pubmed publisher |
| Shimada H, Sato Y, Sasaki T, Shimozawa A, Imaizumi K, Shindo T, et al. A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer. Cell Rep Methods. 2022;2:100289 pubmed publisher |
| Bishay J, Beckett T, Lai A, Hill M, McMahon D, McLaurin J. Venular amyloid accumulation in transgenic Fischer 344 Alzheimer's disease rats. Sci Rep. 2022;12:15287 pubmed publisher |
| Catania M, Colombo L, Sorrentino S, Cagnotto A, Lucchetti J, Barbagallo M, et al. A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer's disease. Mol Psychiatry. 2022;27:5227-5234 pubmed publisher |
| Zhu B, Yang J, Van R, Yang F, Yu Y, Yu A, et al. Epitope alteration by small molecules and applications in drug discovery. Chem Sci. 2022;13:8104-8116 pubmed publisher |
| Lucot K, Bukhari S, Webber E, Bonham T, Darian Smith C, Montine T, et al. Semi-quantitative Assessment of Alzheimer's-like Pathology in Two Aged Polar Bears (Ursus maritimus). Comp Med. 2022;72:267-272 pubmed publisher |
| Wang Q, Huang X, Su Y, Yin G, Wang S, Yu B, et al. Activation of Wnt/β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease. Brain. 2022;145:4474-4488 pubmed publisher |
| Yu W, Aquili L, Wong K, Lo A, Chan L, Chan Y, et al. Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models. Ann N Y Acad Sci. 2022;1515:249-265 pubmed publisher |
| Espinoza S, Grunenwald F, Gómez W, Garc xed a F, Abarz xfa a Catalan L, Oyarce Pezoa S, et al. Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer's Disease. Cells. 2022;11: pubmed publisher |
| Lee J, Yang D, Goulbourne C, Im E, Stavrides P, Pensalfini A, et al. Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nat Neurosci. 2022;: pubmed publisher |
| Feilen L, Chen S, Fukumori A, Feederle R, Zacharias M, Steiner H. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis. elife. 2022;11: pubmed publisher |
| Melikyan Z, Corrada M, Leiby A, Sajjadi S, Bukhari S, Montine T, et al. Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study. Neurobiol Aging. 2022;116:12-15 pubmed publisher |
| Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, et al. Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease. Brain Neurosci Adv. 2022;6:23982128221086464 pubmed publisher |
| Fixemer S, Ameli C, Hammer G, Salamanca L, Uriarte Huarte O, Schwartz C, et al. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol Commun. 2022;10:36 pubmed publisher |
| Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, et al. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. iScience. 2022;25:103869 pubmed publisher |
| Xiong J, Kang S, Wang Z, Liu X, Kuo T, Korkmaz F, et al. FSH blockade improves cognition in mice with Alzheimer's disease. Nature. 2022;603:470-476 pubmed publisher |
| Liu S, Fan M, Xu J, Yang L, Qi C, Xia Q, et al. Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology. J Neuroinflammation. 2022;19:35 pubmed publisher |
| Wirianto M, Wang C, Kim E, Koike N, Gomez Gutierrez R, Nohara K, et al. The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer's disease model. FASEB J. 2022;36:e22186 pubmed publisher |
| Dahl M, Mather M, Werkle Bergner M, Kennedy B, Guzman S, Hurth K, et al. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiol Aging. 2022;112:39-54 pubmed publisher |
| Moon H, Haroutunian V, Zhao L. Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation. Neurobiol Dis. 2022;164:105631 pubmed publisher |
| Abrahamson E, Kofler J, Becker C, Price J, Newell K, Ghetti B, et al. 11C-PiB PET can underestimate brain amyloid-β burden when cotton wool plaques are numerous. Brain. 2022;145:2161-2176 pubmed publisher |
| Smith A, DAVEY K, Tsartsalis S, Khozoie C, Fancy N, Tang S, et al. Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology. Acta Neuropathol. 2022;143:75-91 pubmed publisher |
| Wang C, Huang W, Lu J, Chen H, Yu Z. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline. Front Pharmacol. 2021;12:763866 pubmed publisher |
| Carranza Naval M, Del Marco Á, Hierro Bujalance C, Alves Martínez P, Infante Garcia C, Vargas Soria M, et al. Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer's Disease and Type 2 Diabetes. Front Aging Neurosci. 2021;13:741923 pubmed publisher |
| Schober R, Hilbrich I, J xe4 ger C, Holzer M. Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease. Neuropathology. 2021;41:366-370 pubmed publisher |
| Kim E, Nohara K, Wirianto M, Escobedo G, Lim J, Morales R, et al. Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer's Disease Model. Biomolecules. 2021;11: pubmed publisher |
| Illouz T, Madar R, Hirsh T, Biragyn A, Okun E. Induction of an effective anti-Amyloid-β humoral response in aged mice. Vaccine. 2021;39:4817-4829 pubmed publisher |
| Mol M, Wong T, Melhem S, Basu S, Viscusi R, Galjart N, et al. Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia. Neurol Genet. 2021;7:e596 pubmed publisher |
| Kim E, Di Censo D, Baraldo M, Simmons C, Rosa I, Randall K, et al. In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer's disease. Sci Rep. 2021;11:12419 pubmed publisher |
| Cao K, Kim J, Kroeger H, Gaffney P, Lin J, Sigurdson C, et al. ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol. 2021;10:5 pubmed publisher |
| Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, et al. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein Cell. 2021;12:695-716 pubmed publisher |
| Lu J, Zhou W, Dou F, Wang C, Yu Z. TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease. EMBO Rep. 2021;22:e52013 pubmed publisher |
| Liu X, Qi X, Fang H, Zhou K, Wang Q, Chen G. Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease. Front Aging Neurosci. 2021;13:639318 pubmed publisher |
| Van Skike C, Hussong S, Hernandez S, Banh A, Derosa N, Galvan V. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. J Neurosci. 2021;41:4305-4320 pubmed publisher |
| Wang Z, Xia Y, Liu P, Liu X, Edgington Mitchell L, Lei K, et al. ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2021;202:102032 pubmed publisher |
| Libard S, Walter J, Alafuzoff I. In vivo Characterization of Biochemical Variants of Amyloid-β in Subjects with Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease Neuropathological Change. J Alzheimers Dis. 2021;80:1003-1012 pubmed publisher |
| Crivelli S, Luo Q, Stevens J, Giovagnoni C, van Kruining D, Bode G, et al. CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's disease. Alzheimers Res Ther. 2021;13:45 pubmed publisher |
| Yamamoto S, Kayama T, Noguchi Shinohara M, Hamaguchi T, Yamada M, Abe K, et al. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. NPJ Sci Food. 2021;5:1 pubmed publisher |
| Romani M, Sorrentino V, Oh C, Li H, de Lima T, Zhang H, et al. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Rep. 2021;34:108660 pubmed publisher |
| Fenyi A, Duyckaerts C, Bousset L, Braak H, Del Tredici K, Melki R, et al. Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease. Cells. 2021;10: pubmed publisher |
| Podracky C, An C, DeSousa A, Dorr B, Walsh D, Liu D. Laboratory evolution of a sortase enzyme that modifies amyloid-β protein. Nat Chem Biol. 2021;17:317-325 pubmed publisher |
| Fassler M, Rappaport M, Cuño C, George J. Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models. J Neuroinflammation. 2021;18:19 pubmed publisher |
| Prpar Mihevc S, Zakošek Pipan M, Strbenc M, Rogelj B, Majdic G. Nitrosative Stress in the Frontal Cortex From Dogs With Canine Cognitive Dysfunction. Front Vet Sci. 2020;7:573155 pubmed publisher |
| Saber M, Murphy S, Cho Y, Lifshitz J, Rowe R. Experimental diffuse brain injury and a model of Alzheimer's disease exhibit disease-specific changes in sleep and incongruous peripheral inflammation. J Neurosci Res. 2021;99:1136-1160 pubmed publisher |
| Guo X, Liu Y, Morgan D, Zhao L. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging Dis. 2020;11:1423-1443 pubmed publisher |
| Shi H, Koronyo Y, Fuchs D, Sheyn J, Wawrowsky K, Lahiri S, et al. Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:202 pubmed publisher |
| Uhlmann R, Rother C, Rasmussen J, Schelle J, Bergmann C, Ullrich Gavilanes E, et al. Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life. Nat Neurosci. 2020;23:1580-1588 pubmed publisher |
| Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, et al. Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. Mol Neurodegener. 2020;15:66 pubmed publisher |
| Doustar J, Rentsendorj A, Torbati T, Regis G, Fuchs D, Sheyn J, et al. Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models. Aging Cell. 2020;:e13246 pubmed publisher |
| Sun F, Jiang F, Zhang N, Li H, Tian W, Liu W. Upregulation of Prickle2 Ameliorates Alzheimer's Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2020;8:565020 pubmed publisher |
| Mo D, Li X, Raabe C, Rozhdestvensky T, Skryabin B, Brosius J. Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. Cells. 2020;9: pubmed publisher |
| Guan Z, Chen Z, Fu S, Dai L, Shen Y. Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis. Front Cell Neurosci. 2020;14:260 pubmed publisher |
| Lo Cascio F, Garcia S, Montalbano M, Puangmalai N, McAllen S, Pace A, et al. Modulating disease-relevant tau oligomeric strains by small molecules. J Biol Chem. 2020;295:14807-14825 pubmed publisher |
| Puzzo D, Argyrousi E, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, et al. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. J Clin Invest. 2020;130:4831-4844 pubmed publisher |
| Kim S, Nam Y, Kim C, Lee H, Hong S, Kim H, et al. Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease. Int J Mol Sci. 2020;21: pubmed publisher |
| Rayaprolu S, Gao T, Xiao H, Ramesha S, Weinstock L, Shah J, et al. Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease. Mol Neurodegener. 2020;15:28 pubmed publisher |
| Xu G, Fromholt S, Chakrabarty P, Zhu F, Liu X, Pace M, et al. Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis. Acta Neuropathol Commun. 2020;8:43 pubmed publisher |
| Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed publisher |
| Wu C, Yang L, Li Y, Dong Y, Yang B, Tucker L, et al. Effects of Exercise Training on Anxious-Depressive-like Behavior in Alzheimer Rat. Med Sci Sports Exerc. 2020;52:1456-1469 pubmed publisher |
| Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. J Neurosci. 2020;40:1956-1974 pubmed publisher |
| Jäkel L, Biemans E, Klijn C, Kuiperij H, Verbeek M. Reduced Influence of apoE on Aβ43 Aggregation and Reduced Vascular Aβ43 Toxicity as Compared with Aβ40 and Aβ42. Mol Neurobiol. 2020;57:2131-2141 pubmed publisher |
| Benbow S, Strovas T, Darvas M, Saxton A, Kraemer B. Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans. Hum Mol Genet. 2020;29:495-505 pubmed publisher |
| Elmer B, Swanson K, Bangari D, Piepenhagen P, Roberts E, Taksir T, et al. Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease. PLoS ONE. 2019;14:e0226245 pubmed publisher |
| Song J, Malampati S, Zeng Y, Durairajan S, Yang C, Tong B, et al. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2019;:e13069 pubmed publisher |
| Iacono D, Lee P, Edlow B, Gray N, Fischl B, Kenney K, et al. Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity. J Neuropathol Exp Neurol. 2020;79:144-162 pubmed publisher |
| Pires G, McElligott S, Drusinsky S, Halliday G, Potier M, Wisniewski T, et al. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta Neuropathol Commun. 2019;7:195 pubmed publisher |
| Trambauer J, Rodríguez Sarmiento R, Fukumori A, Feederle R, Baumann K, Steiner H. Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation. EMBO Rep. 2020;21:e47996 pubmed publisher |
| Carrillo Jimenez A, Deniz O, Niklison Chirou M, Ruiz R, Bezerra Salomão K, Stratoulias V, et al. TET2 Regulates the Neuroinflammatory Response in Microglia. Cell Rep. 2019;29:697-713.e8 pubmed publisher |
| Jäkel L, Boche D, Nicoll J, Verbeek M. Aβ43 in human Alzheimer's disease: effects of active Aβ42 immunization. Acta Neuropathol Commun. 2019;7:141 pubmed publisher |
| Kim S, Nam Y, Jeong Y, Park H, Lee S, Shin S, et al. Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2019;20: pubmed publisher |
| Ezpeleta J, Baudouin V, Arellano Anaya Z, Boudet Devaud F, Pietri M, Baudry A, et al. Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation. Nat Commun. 2019;10:3442 pubmed publisher |
| Wang Z, Xiang J, Liu X, Yu S, Manfredsson F, Sandoval I, et al. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019;28:655-669.e5 pubmed publisher |
| Zhao P, Qian X, Nie Y, Sun N, Wang Z, Wu J, et al. Neuropeptide S Ameliorates Cognitive Impairment of APP/PS1 Transgenic Mice by Promoting Synaptic Plasticity and Reducing Aβ Deposition. Front Behav Neurosci. 2019;13:138 pubmed publisher |
| Prpar Mihevc S, Majdic G. Canine Cognitive Dysfunction and Alzheimer's Disease - Two Facets of the Same Disease?. Front Neurosci. 2019;13:604 pubmed publisher |
| Harper M, Hedberg Buenz A, Herlein J, Abrahamson E, Anderson M, Kuehn M, et al. Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci. 2019;60:2716-2725 pubmed publisher |
| Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, et al. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging Cell. 2019;18:e12978 pubmed publisher |
| Jovic M, Loncarevic Vasiljkovic N, Ivkovic S, Dinic J, Milanovic D, Zlokovic B, et al. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. PLoS ONE. 2019;14:e0216726 pubmed publisher |
| Wang W, Hou T, Jia L, Wu Q, Quan M, Jia J. Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury. EBioMedicine. 2019;42:174-187 pubmed publisher |
| Luo R, Su L, Li G, Yang J, Liu Q, Yang L, et al. Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy. 2019;:1-18 pubmed publisher |
| Grant M, Handoko M, Rozga M, Brinkmalm G, Portelius E, Blennow K, et al. Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments. PLoS ONE. 2019;14:e0212815 pubmed publisher |
| Li J, Chiu J, Pratico D. Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35. Mol Psychiatry. 2019;: pubmed publisher |
| Wu Y, Du S, Johnson J, Tung H, Landers C, Liu Y, et al. Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. Nat Commun. 2019;10:58 pubmed publisher |
| Dolfe L, Tambaro S, Tigro H, Del Campo M, Hoozemans J, Wiehager B, et al. The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques. J Alzheimers Dis Rep. 2018;2:27-39 pubmed publisher |
| Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, et al. Specific amyloid-β42 deposition in the brain of a Gerstmann-Sträussler-Scheinker disease patient with a P105L mutation on the prion protein gene. Prion. 2018;12:315-319 pubmed publisher |
| Rush T, Martínez Hernández J, Dollmeyer M, Lise Frandemiche M, Borel E, Boisseau S, et al. Synaptotoxicity in Alzheimer's disease involved a dysregulation of actin cytoskeleton dynamics through cofilin 1 phosphorylation. J Neurosci. 2018;: pubmed publisher |
| Iacono D, Geraci Erck M, Peng H, Rabin M, Kurlan R. Hypertrophy of nigral neurons in Torsin1A deletion (DYT1) carriers manifesting dystonia. Parkinsonism Relat Disord. 2019;58:63-69 pubmed publisher |
| Gonzalez C, Armijo E, Bravo Alegria J, Becerra Calixto A, Mays C, Soto C. Modeling amyloid beta and tau pathology in human cerebral organoids. Mol Psychiatry. 2018;23:2363-2374 pubmed publisher |
| Eimer W, Vijaya Kumar D, Navalpur Shanmugam N, Rodriguez A, Mitchell T, Washicosky K, et al. Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 2018;99:56-63.e3 pubmed publisher |
| Braak H, Del Tredici K. Spreading of Tau Pathology in Sporadic Alzheimer's Disease Along Cortico-cortical Top-Down Connections. Cereb Cortex. 2018;28:3372-3384 pubmed publisher |
| Jonson M, Nyström S, Sandberg A, Carlback M, Michno W, Hanrieder J, et al. Aggregated Aβ1-42 Is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila. Cell Chem Biol. 2018;25:595-610.e5 pubmed publisher |
| Osborne C, West E, Bate C. The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage. J Cell Sci. 2018;131: pubmed publisher |
| Zhang L, Trushin S, Christensen T, Tripathi U, Hong C, Geroux R, et al. Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane. Neurobiol Dis. 2018;114:1-16 pubmed publisher |
| Chiang A, Fowler S, Reddy R, Pletnikova O, Troncoso J, Sherman M, et al. Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018;188:739-756 pubmed publisher |
| Rivera I, Capone R, Cauvi D, Arispe N, De Maio A. Modulation of Alzheimer's amyloid β peptide oligomerization and toxicity by extracellular Hsp70. Cell Stress Chaperones. 2018;23:269-279 pubmed publisher |
| Colvin B, Rogers V, Kulas J, Ridgway E, Amtashar F, Combs C, et al. The conformational epitope for a new A?42 protofibril-selective antibody partially overlaps with the peptide N-terminal region. J Neurochem. 2017;143:736-749 pubmed publisher |
| Lauretti E, Iuliano L, Pratico D. Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol. 2017;4:564-574 pubmed publisher |
| Lee K, Seo S, Lim T, Kim E, Kim B, Kim Y, et al. Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea. Yonsei Med J. 2017;58:1055-1060 pubmed publisher |
| West E, Osborne C, Bate C. The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-?. J Cell Sci. 2017;130:3050-3059 pubmed publisher |
| Plá V, Barranco N, Pozas E, Aguado F. Amyloid-β Impairs Vesicular Secretion in Neuronal and Astrocyte Peptidergic Transmission. Front Mol Neurosci. 2017;10:202 pubmed publisher |
| Finke J, Ayres K, Brisbin R, Hill H, Wing E, Banks W. Antibody blood-brain barrier efflux is modulated by glycan modification. Biochim Biophys Acta Gen Subj. 2017;1861:2228-2239 pubmed publisher |
| Garcia Esparcia P, Lopez Gonzalez I, Grau Rivera O, García Garrido M, Konetti A, Llorens F, et al. Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms. Front Neurol. 2017;8:89 pubmed publisher |
| Nuvolone M, Schmid N, Miele G, Sorce S, Moos R, Schori C, et al. Cystatin F is a biomarker of prion pathogenesis in mice. PLoS ONE. 2017;12:e0171923 pubmed publisher |
| Cacciottolo M, Wang X, Driscoll I, Woodward N, Saffari A, Reyes J, et al. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Transl Psychiatry. 2017;7:e1022 pubmed publisher |
| Liu L, Yu J, Li L, Zhang B, Liu L, Wu C, et al. Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine. Sci Rep. 2017;7:40467 pubmed publisher |
| Loke S, Wong P, Ong W. Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension. Neurochem Int. 2017;102:33-56 pubmed publisher |
| Kimura A, Hata S, Suzuki T. Alternative Selection of ?-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid ?-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the A? Sequence. J Biol Chem. 2016;291:24041-24053 pubmed |
| Sherman M, LaCroix M, Amar F, Larson M, Forster C, Aguzzi A, et al. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci. 2016;36:9647-58 pubmed publisher |
| Wang B, Liu Y, Huang L, Chen J, Li J, Wang R, et al. A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. Mol Psychiatry. 2017;22:990-1001 pubmed publisher |
| Lian H, Litvinchuk A, Chiang A, Aithmitti N, Jankowsky J, Zheng H. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease. J Neurosci. 2016;36:577-89 pubmed publisher |
| Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016;50:517-25 pubmed publisher |
| Liu P, Reed M, Kotilinek L, Grant M, Forster C, Qiang W, et al. Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Rep. 2015;11:1760-71 pubmed publisher |
| Chapuis J, Vingtdeux V, Capiralla H, Davies P, Marambaud P. Gas1 interferes with A?PP trafficking by facilitating the accumulation of immature A?PP in endoplasmic reticulum-associated raft subdomains. J Alzheimers Dis. 2012;28:127-35 pubmed publisher |
