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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-XBP-1s
catalog :
647501
quantity :
25 μg
price :
124 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
143F
reactivity :
human
application :
western blot, immunocytochemistry, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 3c
Walter F, D Orsi B, Jagannathan A, Dussmann H, Prehn J. BOK controls ER proteostasis and physiological ER stress responses in neurons. Front Cell Dev Biol. 2022;10:915065 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3c
Zang M, Guo J, Liu L, Jin F, Feng X, An G, et al. Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s. Oncogenesis. 2020;9:31 pubmed publisher
  • flow cytometry; human; loading ...; fig 2b
Ye Y, Liu M, Tang L, Du F, Liu Y, Hao P, et al. Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis. Arthritis Res Ther. 2019;21:92 pubmed publisher
  • western blot; human
D Osualdo A, Anania V, Yu K, Lill J, Kaufman R, Matsuzawa S, et al. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. PLoS ONE. 2015;10:e0130635 pubmed publisher
Pietrafesa G, De Zio R, Scorza S, Armentano M, Pepe M, Forleo C, et al. Targeting unfolded protein response reverts ER stress and ER Ca2+ homeostasis in cardiomyocytes expressing the pathogenic variant of Lamin A/C R321X. J Transl Med. 2023;21:340 pubmed publisher
El Gazzar A, Voraberger B, Rauch F, Mairhofer M, Schmidt K, Guillemyn B, et al. Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress. EMBO Mol Med. 2023;15:e16834 pubmed publisher
Chen W, Liu P, Liu D, Huang H, Feng X, Fang F, et al. Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. Nat Commun. 2022;13:6796 pubmed publisher
Devireddy S, Ferguson S. Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. J Cell Biol. 2022;221: pubmed publisher
Rinaldi R, Miglionico R, Nigro I, D Orsi R, Chiummiento L, Funicello M, et al. Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2. Cells. 2021;10: pubmed publisher
Hattori K, Takano N, Kazama H, Moriya S, Miyake K, Hiramoto M, et al. Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells. Oncol Lett. 2021;22:680 pubmed publisher
Efimova I, Steinberg I, Zvibel I, Neumann A, Mantelmacher D, Drucker D, et al. GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice. Front Immunol. 2021;12:643144 pubmed publisher
Syx D, Ishikawa Y, Gebauer J, Boudko S, Guillemyn B, Van Damme T, et al. Aberrant binding of mutant HSP47 affects posttranslational modification of type I collagen and leads to osteogenesis imperfecta. PLoS Genet. 2021;17:e1009339 pubmed publisher
Zielke S, Kardo S, Zein L, Mari M, Covarrubias Pinto A, Kinzler M, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2020;:1-17 pubmed publisher
Gruber C, Patel R, Trachtman R, Lepow L, Amanat F, Krammer F, et al. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Cell. 2020;183:982-995.e14 pubmed publisher
Michlmayr D, Kim E, Rahman A, Raghunathan R, Kim Schulze S, Che Y, et al. Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection. Cell Rep. 2020;31:107569 pubmed publisher
Lindner P, Christensen S, Nissen P, Møller J, Engedal N. Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components. Cell Commun Signal. 2020;18:12 pubmed publisher
Talty A, Deegan S, Ljujic M, Mnich K, Naicker S, Quandt D, et al. Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β. Cell Death Dis. 2019;10:622 pubmed publisher
Luhr M, Torgersen M, Szalai P, Hashim A, Brech A, Staerk J, et al. The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. J Biol Chem. 2019;294:8197-8217 pubmed publisher
Miyoshi A, Koyama S, Sasagawa Monden M, Kadoya M, Konishi K, Shoji T, et al. JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation end products. FASEB J. 2019;33:3575-3589 pubmed publisher
Li J, Zhang Y, Da Silva Sil Dos Santos B, Wang F, Ma Y, Pérez C, et al. Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell Chem Biol. 2018;25:1350-1358.e9 pubmed publisher
Li X, Pan E, Zhu J, Xu L, Chen X, Li J, et al. Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress. Sci Rep. 2018;8:3496 pubmed publisher
Cai X, Chen L, McGinnis J. Correlation of ER stress and retinal degeneration in tubby mice. Exp Eye Res. 2015;140:130-138 pubmed publisher
Rodriguez M, Domingo E, Alonso S, Frade J, Eiros J, Crespo M, et al. The unfolded protein response and the phosphorylations of activating transcription factor 2 in the trans-activation of il23a promoter produced by ?-glucans. J Biol Chem. 2014;289:22942-57 pubmed publisher
Bonetti P, Testoni M, Scandurra M, Ponzoni M, Piva R, Mensah A, et al. Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma. Blood. 2013;122:2233-41 pubmed publisher
Dickie L, Aziz A, Savic S, Lucherini O, Cantarini L, Geiler J, et al. Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome. Ann Rheum Dis. 2012;71:2035-43 pubmed publisher
Byrd A, Aragon I, Brewer J. MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. J Cell Biol. 2012;196:689-98 pubmed publisher
Vidal R, Figueroa A, Court F, Thielen P, Molina C, Wirth C, et al. Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum Mol Genet. 2012;21:2245-62 pubmed publisher
Shirley C, Chen J, Shamay M, Li H, Zahnow C, Hayward S, et al. Bortezomib induction of C/EBP? mediates Epstein-Barr virus lytic activation in Burkitt lymphoma. Blood. 2011;117:6297-303 pubmed publisher
Liu Y, Lee S, Neely E, Nandar W, Moyo M, Simmons Z, et al. Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. J Biol Chem. 2011;286:13161-70 pubmed publisher
Wang L, Popko B, Roos R. The unfolded protein response in familial amyotrophic lateral sclerosis. Hum Mol Genet. 2011;20:1008-15 pubmed publisher
Li J, Wang J, Zhang S. Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1. J Biol Chem. 2011;286:4912-21 pubmed publisher
Farhan H, Wendeler M, Mitrovic S, Fava E, Silberberg Y, Sharan R, et al. MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening. J Cell Biol. 2010;189:997-1011 pubmed publisher
Tsang K, Chan D, Cheslett D, Chan W, So C, Melhado I, et al. Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function. PLoS Biol. 2007;5:e44 pubmed
product information
Antigen :
XBP-1s
Apps. Abbrev. :
WB, ChIP, ICC, IHC-P
Cat # :
647501
Clone :
143F
Item :
Purified anti-XBP-1s
Isotype :
Mouse IgG2a, κ
Other Names :
X-box binding protein 1
Size :
25 μg
Price (USD) :
124 USD
Reactivity :
Human
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
XBP-1s recombinant protein
Application Notes :
Additional reported applications (for the relevant formats) include: immunofluorescence^14 and immunohistochemical staining of PFA-fixed paraffin-embedded sections^1,14.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA