product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
Purified anti-Ubiquitin
catalog :
646301
quantity :
25 μg
price :
124 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P4D1
reactivity :
human, brewer's yeast
application :
western blot, immunohistochemistry, immunoprecipitation
more info or order :
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; brewer's yeast; loading ...; fig 7b
Defenouillère Q, Namane A, Mouaikel J, Jacquier A, Fromont Racine M. The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation. Mol Biol Cell. 2017;28:1165-1176 pubmed publisher
Lah S, Kim S, Kang I, Kim H, Hupperetz C, Jung H, et al. Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locus. J Immunother Cancer. 2023;11: pubmed publisher
Liu X, Kalogeropulou A, Domingos S, Makukhin N, Nirujogi R, Singh F, et al. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. J Am Chem Soc. 2022;144:16930-16952 pubmed publisher
Zhang A, Huang Z, Tao W, Zhai K, Wu Q, Rich J, et al. USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells. EMBO J. 2022;41:e109187 pubmed publisher
Mennerich D, Kubaichuk K, Raza G, Fuhrmann D, Herzig K, Br xfc ne B, et al. ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP. Redox Biol. 2022;50:102243 pubmed publisher
Singh F, Prescott A, Rosewell P, Ball G, Reith A, Ganley I. Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice. elife. 2021;10: pubmed publisher
Kanamori T, Miyazaki N, Aoki S, Ito K, Hisaka A, Hatakeyama H. Investigation of energy metabolic dynamism in hyperthermia-resistant ovarian and uterine cancer cells under heat stress. Sci Rep. 2021;11:14726 pubmed publisher
De Cesare V, Carbajo Lopez D, Mabbitt P, Fletcher A, Soetens M, Antico O, et al. Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Malik A, Karapetsas A, Nirujogi R, Mathea S, Chatterjee D, Pal P, et al. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. Biochem J. 2021;478:553-578 pubmed publisher
Martins Marques T, Ribeiro Rodrigues T, de Jager S, Zuzarte M, Ferreira C, Cruz P, et al. Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Sci Alliance. 2020;3: pubmed publisher
Wu W, Chen Y, Huang L, Li W, Tao C, Shen H. Point mutation screening of tumor neoantigens and peptide-induced specific cytotoxic T lymphocytes using The Cancer Genome Atlas database. Oncol Lett. 2020;20:123 pubmed publisher
Feng T, Mai S, Roscoe J, Sheng R, Ullah M, Zhang J, et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020;21:e50219 pubmed publisher
Abreu A, Toro C, Song Y, Navarro V, Bosch M, Eren A, et al. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons. J Clin Invest. 2020;: pubmed publisher
Harris I, Endress J, Coloff J, Selfors L, McBrayer S, Rosenbluth J, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019;29:1166-1181.e6 pubmed publisher
Shi Y, Zhou W, Cheng L, Chen C, Huang Z, Fang X, et al. Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells. Cell Death Differ. 2017;24:167-180 pubmed publisher
Rousseau A, Bertolotti A. An evolutionarily conserved pathway controls proteasome homeostasis. Nature. 2016;536:184-9 pubmed
Deguise M, Boyer J, McFall E, Yazdani A, De Repentigny Y, Kothary R. Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. Sci Rep. 2016;6:28846 pubmed publisher
Magnaudeix A, Wilson C, Page G, Bauvy C, Codogno P, Leveque P, et al. PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging. 2013;34:770-90 pubmed publisher
product information
Antigen :
Ubiquitin
Apps. Abbrev. :
WB, IP, IHC
Cat # :
646301
Clone :
P4D1
Item :
Purified anti-Ubiquitin
Isotype :
Mouse IgG1, κ
Size :
25 μg
Price (USD) :
124 USD
Reactivity :
All Species
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PURE
Immunogen :
Denatured glutaraldehyde cross-linked ubiquitin IgG complex
Application Notes :
This antibody recognizes ubiquitin, polyubiquitin, and ubiquitin-conjugated proteins. The ubiquitin protein is extremley well conserved and thus the antibody has extensive species cross-reactivity from yeast to human. This antibody was specifically developed to detect ubiquitin and ubiquitin-substrate conjugates by immunoblotting. Because the antibody recognizes a denatured epitope, it is known to not work in immunoprecipitation or immunostaining applications.;
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA