product summary
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company name :
BioLegend
other brands :
Babco, Signet, Sternberger Monoclonals, Senetek, Covance
product type :
antibody
product name :
PE/Cyanine7 anti-T-bet
catalog :
644823
quantity :
25 μg
price :
171 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE/Cy7
clone name :
4B10
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; 1:1000; loading ...; fig s3k
Sokal A, Chappert P, Barba Spaeth G, Roeser A, Fourati S, Azzaoui I, et al. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response. Cell. 2021;184:1201-1213.e14 pubmed publisher
  • flow cytometry; human; loading ...; fig s3c
Rodda L, Netland J, Shehata L, Pruner K, Morawski P, Thouvenel C, et al. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021;184:169-183.e17 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4a
Jimeno R, Lebrusant Fernandez M, Margreitter C, LUCAS B, Veerapen N, Kelly G, et al. Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; loading ...; fig e8b
Alspach E, Lussier D, Miceli A, Kizhvatov I, DuPage M, Luoma A, et al. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. 2019;574:696-701 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4c, 4e, s6c
Ansaldo E, Slayden L, Ching K, Koch M, Wolf N, Plichta D, et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019;364:1179-1184 pubmed publisher
Clark J, Weizman O, Aldridge D, Shallberg L, Eberhard J, Lanzar Z, et al. IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. Cell Rep. 2023;42:112147 pubmed publisher
Merchak A, Cahill H, Brown L, Brown R, Rivet Noor C, Beiter R, et al. The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation. PLoS Biol. 2023;21:e3002000 pubmed publisher
Ogishi M, Yang R, Rodriguez R, Golec D, Martin E, Philippot Q, et al. Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis. J Exp Med. 2023;220: pubmed publisher
Chen R, Nabila A, Phalke S, Castro D, Toth J, Bergin P, et al. Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture. iScience. 2022;25:105595 pubmed publisher
Jowett G, Read E, Roberts L, Coman D, Vil xe0 Gonz xe1 lez M, Zabinski T, et al. Organoids capture tissue-specific innate lymphoid cell development in mice and humans. Cell Rep. 2022;40:111281 pubmed publisher
Csomós K, Ujhazi B, Blazso P, Herrera J, Tipton C, Kawai T, et al. Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells. Nat Immunol. 2022;23:1256-1272 pubmed publisher
Herati R, Knorr D, Vella L, Silva L, Chilukuri L, Apostolidis S, et al. PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nat Immunol. 2022;23:1183-1192 pubmed publisher
Jung S, Jung J, Noh J, Kim W, Yoon S, Jung J, et al. The generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8+ T cell responses. Cell Rep. 2022;40:111138 pubmed publisher
Giles J, Manne S, Freilich E, Oldridge D, Baxter A, George S, et al. Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers. Immunity. 2022;55:557-574.e7 pubmed publisher
Ozga A, Chow M, Lopes M, Servis R, Di Pilato M, Dehio P, et al. CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection. Immunity. 2022;55:82-97.e8 pubmed publisher
Duan Q, Ding J, Li F, Liu X, Zhao Y, Yu H, et al. Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation. Front Cell Dev Biol. 2021;9:761193 pubmed publisher
Wilfahrt D, Philips R, Lama J, Kizerwetter M, Shapiro M, McCue S, et al. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. elife. 2021;10: pubmed publisher
Russler Germain E, Jung J, Miller A, Young S, Yi J, Wehmeier A, et al. Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections. Immunity. 2021;54:2547-2564.e7 pubmed publisher
Hern xe1 ndez D, Juelke K, M xfc ller N, Durek P, Ugursu B, Mashreghi M, et al. An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity. Immunity. 2021;54:2417-2432.e5 pubmed publisher
Marques R, Gonzalez Nuñez M, Walker M, Gómez E, Colas R, Montero Melendez T, et al. Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions. Cell Death Differ. 2021;28:3140-3160 pubmed publisher
Krueger P, Goldberg M, Hong S, Osum K, Langlois R, Kotov D, et al. Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells. Immunity. 2021;54:687-701.e4 pubmed publisher
Gern B, Adams K, Plumlee C, Stoltzfus C, Shehata L, Moguche A, et al. TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma. Cell Host Microbe. 2021;29:594-606.e6 pubmed publisher
Russler Germain E, Yi J, Young S, Nutsch K, Wong H, Ai T, et al. Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation. elife. 2021;10: pubmed publisher
Yang R, Mele F, Worley L, Langlais D, Rosain J, Benhsaien I, et al. Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria. Cell. 2020;183:1826-1847.e31 pubmed publisher
Harsha Krovi S, Zhang J, Michaels Foster M, Brunetti T, Loh L, Scott Browne J, et al. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020;11:6238 pubmed publisher
Baranek T, Lebrigand K, de Amat Herbozo C, Gonzalez L, Bogard G, Dietrich C, et al. High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision. Cell Rep. 2020;32:108116 pubmed publisher
Sjaastad F, Kucaba T, Dileepan T, Swanson W, Dail C, Cabrera Perez J, et al. Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity. Front Immunol. 2020;11:1786 pubmed publisher
Bhattacharya P, Ellegård R, Khalid M, Svanberg C, Govender M, Keita A, et al. Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells. elife. 2020;9: pubmed publisher
Kaya B, Doñas C, Wuggenig P, Diaz O, Morales R, Melhem H, et al. Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis. Cell Rep. 2020;32:107979 pubmed publisher
Borges da Silva H, Peng C, Wang H, Wanhainen K, Ma C, Lopez S, et al. Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β. Immunity. 2020;53:158-171.e6 pubmed publisher
Silver J, Humbles A, Ohne Y. Isolation, Culture, and Induction of Plasticity in ILC2s. Methods Mol Biol. 2020;2121:115-127 pubmed publisher
Joubert I, Kovacs D, Scheiblhofer S, Winter P, Korotchenko E, Strandt H, et al. Mast cells and γδ T cells are largely dispensable for adaptive immune responses after laser-mediated epicutaneous immunization. Vaccine. 2020;38:1015-1024 pubmed publisher
Elsner R, Shlomchik M. IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression. Cell Rep. 2019;29:2796-2809.e5 pubmed publisher
Ly A, Liao Y, Pietrzak H, Ioannidis L, Sidwell T, Gloury R, et al. Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria. Cell Rep. 2019;29:2257-2269.e6 pubmed publisher
Trittel S, Chambers B, Heise U, Guzman C, Riese P. Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells. Sci Rep. 2019;9:16362 pubmed publisher
Lamichhane R, Schneider M, de la Harpe S, Harrop T, Hannaway R, Dearden P, et al. TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses. Cell Rep. 2019;28:3061-3076.e5 pubmed publisher
Sharma M, Schlegel M, Brown E, Sansbury B, Weinstock A, Afonso M, et al. Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity. Immunometabolism. 2019;1: pubmed publisher
Gaylo Moynihan A, Prizant H, Popovic M, Fernandes N, Anderson C, Chiou K, et al. Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites. Immunity. 2019;51:298-309.e6 pubmed publisher
Andrews S, Chambers M, Schramm C, Plyler J, Raab J, Kanekiyo M, et al. Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin. Immunity. 2019;51:398-410.e5 pubmed publisher
Sasaki T, Moro K, Kubota T, Kubota N, Kato T, Ohno H, et al. Innate Lymphoid Cells in the Induction of Obesity. Cell Rep. 2019;28:202-217.e7 pubmed publisher
Franchini D, Lanvin O, Tosolini M, Patras de Campaigno E, Cammas A, Péricart S, et al. Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells. Cell Rep. 2019;26:94-107.e7 pubmed publisher
Kim C, Lee C, Jung J, Ghosh A, Hasan S, Hwang S, et al. The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus. Immunity. 2018;49:1034-1048.e8 pubmed publisher
Tsai S, Clemente Casares X, Zhou A, Lei H, Ahn J, Chan Y, et al. Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection. Cell Metab. 2018;28:922-934.e4 pubmed publisher
Hong M, Gu B, Madison M, Landers C, Tung H, Kim M, et al. Protective role of γδ T cells in cigarette smoke and influenza infection. Mucosal Immunol. 2018;11:894-908 pubmed publisher
Miyauchi K, Sugimoto Ishige A, Harada Y, Adachi Y, Usami Y, Kaji T, et al. Protective neutralizing influenza antibody response in the absence of T follicular helper cells. Nat Immunol. 2016;17:1447-1458 pubmed publisher
Hsieh C, Chen C, Tsai C, Huang W, Tseng P, Lin Y, et al. Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol-13-acetate-induced interferon-?-mediated skin inflammation. J Pharmacol Exp Ther. 2012;343:125-33 pubmed publisher
product information
Antigen :
T-bet
Apps. Abbrev. :
ICFC
Cat # :
644823
Clone :
4B10
Item :
PE/Cyanine7 anti-T-bet
Isotype :
Mouse IgG1, κ
Other Names :
T-box expressed in T cells, T box 21, TBLYM
Size :
25 μg
Price (USD) :
171 USD
Reactivity :
Human, Mouse
Clonality :
Monoclonal
Host :
Mouse
Conjugate/Tag/Label :
PE_CYANINE7
more info or order :
company information
BioLegend
8999 BioLegend Way
San Diego, CA 92121
customerserv@biolegend.com
https://www.biolegend.com
headquarters: USA